Cardiovascular System - Coronary Circulation Development: Difference between revisions
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* '''Coronary arteries form by developmental reprogramming of venous cells''' <ref><pubmed>20336138</pubmed></ref> "Here we show, using histological and clonal analysis in mice and cardiac organ culture, that coronary vessels arise from angiogenic sprouts of the sinus venosus-the vein that returns blood to the embryonic heart. Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium. Invading cells differentiate into arteries and capillaries; cells on the surface redifferentiate into veins. These results show that some differentiated venous cells retain developmental plasticity, and indicate that position-specific cardiac signals trigger their dedifferentiation and conversion into coronary arteries, capillaries and veins." | * '''Coronary arteries form by developmental reprogramming of venous cells''' <ref name="PMID20336138"><pubmed>20336138</pubmed></ref> "Here we show, using histological and clonal analysis in mice and cardiac organ culture, that coronary vessels arise from angiogenic sprouts of the sinus venosus-the vein that returns blood to the embryonic heart. Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium. Invading cells differentiate into arteries and capillaries; cells on the surface redifferentiate into veins. These results show that some differentiated venous cells retain developmental plasticity, and indicate that position-specific cardiac signals trigger their dedifferentiation and conversion into coronary arteries, capillaries and veins." | ||
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==Mouse Coronary Vessel Development== | |||
[[File:Mouse-coronary vessel formation.jpg]] | |||
==References== | ==References== |
Revision as of 18:08, 15 October 2010
Introduction
Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic) the embryo. Vascular development therefore occurs in many places, the most obvious though is the early forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo.
The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.
Some Recent Findings
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Mouse Coronary Vessel Development
References
- ↑ <pubmed>20336138</pubmed>
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See also Category:Heart ILP and Category:Heart
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Cite this page: Hill, M.A. (2024, June 20) Embryology Cardiovascular System - Coronary Circulation Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Coronary_Circulation_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G