Paper - Ventricular system and choroid plexuses of the human brain during the embryonic period proper

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O'Rahilly R. and Müller F. Ventricular system and choroid plexuses of the human brain during the embryonic period proper. (1990) Amer. J Anat.189(4); 285-302 PMID 2285038

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This 1990 paper by O'Rahilly and Müller uses the Carnegie Collection embryos to characterise the development of the ventricular system and choroid plexuses during the embryonic period.


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Ventricular system and choroid plexuses of the human brain during the embryonic period proper

O'Rahilly R. and Müller F.

DOI: 10.1002/aja.1001890402

Abstract

This morphological study, based on serial sections and graphic reconstructions at 4-8 postovulatory weeks (stages 11-23), is believed to be the first account of the ventricular system in staged human embryos. Closure of the caudal neuropore at stage 12 heralds the onset of the ventricular system and separates the ependymal from the amniotic fluid. After the appearance of the optic ventricle at stage 11, the cavity of the telencephalon medium is discernible at stage 13. At stage 14 the future cerebral hemispheres and lateral ventricles begin, and the rhomboid fossa becomes apparent. The medial and lateral ventricular eminences cause indentations in the lateral ventricle by stage 15. The hypothalamic sulcus is evident at stage 16. At stages 17-18 the interventricular foramina are becoming relatively smaller, and cellular accumulations indicate the future choroid villi of the fourth and lateral ventricles. The areae membranaceae rostralis and caudalis are visible in the roof of the fourth ventricle at stage 18, and the paraphysis is appearing. At stage 19 choroid villi are seen in the fourth ventricle, and a mesencephalic evagination (Blindsack) is detectable. Choroid villi are noticeable in the lateral ventricle at stage 20. An olfactory ventricle is present by stage 21. At about stages 21-23 the lateral ventricle has become C-shaped, so that anterior and inferior horns are visible. Several recesses, e.g., the optic, infundibular, and pineal, develop in the third ventricle during the embryonic period. Features of the ventricular system that do not become apparent until the fetal period include the posterior horn of the lateral ventricle, choroid plexus of the third ventricle, suprapineal recess, interthalamic adhesion, aqueduct, and apertures in the roof of the fourth ventricle.


Table below is based on data from this reference.


Human Embryonic Ventricular Timeline
Week Carnegie Stage Event
Week 4 11 appearance of the optic ventricle. The neural groove/tube space is initially filled with amniotic fluid.
12 closure of the caudal neuropore, onset of the ventricular system and separates the ependymal from the amniotic fluid.
13 cavity of the telencephalon medium is visible.
Week 5 14 cerebral hemispheres and lateral ventricles begin, rhomboid fossa becomes apparent.
15 medial and lateral ventricular eminences cause indentations in the lateral ventricle
Week 6 16 hypothalamic sulcus is evident.
17 - 18 interventricular foramina are becoming relatively smaller, and cellular accumulations indicate the future choroid villi of the fourth and lateral ventricles.
Week 7 18 areae membranaceae rostralis and caudalis are visible in the roof of the fourth ventricle, and the paraphysis is appearing.
19 choroid villi are visible in the fourth ventricle, and a mesencephalic evagination (blindsack) is visible
Week 8 20 choroid villi are visible in the lateral ventricle.
21 olfactory ventricle is visible.
21 - 23 lateral ventricle has become C-shaped (anterior and inferior horns visible). Recesses develop in the third ventricle (optic, infundibular, pineal).
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Links: ventricular | neural | timeline | Category:Timeline     Table Data Reference[1]


Human Embryonic Ventricular Timeline  
Week Carnegie Stage Event
Week 4 Stage 11 appearance of the optic ventricle. The neural groove/tube space is initially filled with amniotic fluid.
Stage 12 closure of the caudal neuropore, onset of the ventricular system and separates the ependymal from the amniotic fluid.
Stage 13 cavity of the telencephalon medium is visible.
Week 5 Stage 14 cerebral hemispheres and lateral ventricles begin, rhomboid fossa becomes apparent.
Stage 15 medial and lateral ventricular eminences cause indentations in the lateral ventricle
Week 6 Stage 16 hypothalamic sulcus is evident.
Stages 17 - 18 interventricular foramina are becoming relatively smaller, and cellular accumulations indicate the future choroid villi of the fourth and lateral ventricles.
Week 7 Stage 18 areae membranaceae rostralis and caudalis are visible in the roof of the fourth ventricle, and the paraphysis is appearing.
Stage 19 choroid villi are visible in the fourth ventricle, and a mesencephalic evagination (blindsack) is visible
Week 8 Stage 20 choroid villi are visible in the lateral ventricle.
Stage 21 olfactory ventricle is visible.
Stages 21-23 lateral ventricle has become C-shaped (anterior and inferior horns visible). Recesses develop in the third ventricle (optic, infundibular, pineal).
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Reference: O'Rahilly R. and Müller F. Ventricular system and choroid plexuses of the human brain during the embryonic period proper. (1990) Amer. J Anat.189(4); 285-302 PMID 2285038



Cite this page: Hill, M.A. (2019, September 23) Embryology Paper - Ventricular system and choroid plexuses of the human brain during the embryonic period proper. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Ventricular_system_and_choroid_plexuses_of_the_human_brain_during_the_embryonic_period_proper

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  1. O'Rahilly R. and Müller F. Ventricular system and choroid plexuses of the human brain during the embryonic period proper. (1990) Amer. J Anat.189(4); 285-302 PMID 2285038