Musculoskeletal System - Muscle Development Timeline

From Embryology
Embryology - 9 Dec 2018    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Introduction

These notes summarise the timecourse of development of skeletal muscle in humans.


Musculoskeletal Links: Introduction | mesoderm | somitogenesis | limb | cartilage | bone | bone timeline | shoulder | pelvis | axial skeleton | skull | joint | skeletal muscle | muscle timeline | tendon | diaphragm | Lecture - Musculoskeletal | Lecture Movie | musculoskeletal abnormalities | limb abnormalities | developmental hip dysplasia | cartilage histology | bone histology | Skeletal Muscle Histology | Category:Musculoskeletal
Historic Musculoskeletal Embryology  
1853 Bone | 1885 Sphenoid | 1902 - Pubo-femoral Region | Spinal Column and Back | Body Segmentation | Cranium | Body Wall, Ribs, and Sternum | Limbs | 1901 - Limbs | 1902 - Arm Development | 1906 Human Embryo Ossification | 1906 Lower limb Nerves and Muscle | 1907 - Muscular System | Skeleton and Limbs | 1908 Vertebra | 1908 Cervical Vertebra | 1909 Mandible | 1910 - Skeleton and Connective Tissues | Muscular System | Coelom and Diaphragm | 1913 Clavicle | 1920 Clavicle | 1921 - External body form | Connective tissues and skeletal | Muscular | Diaphragm | 1929 Rat Somite | 1932 Pelvis | 1940 Synovial Joints | 1943 Human Embryonic, Fetal and Circumnatal Skeleton | 1947 Joints | 1949 Cartilage and Bone | 1957 Chondrification Hands and Feet | 1968 Knee

Some Recent Findings

  • Muscle patterning in mouse and human abdominal wall development and omphalocele specimens of humans.[1] "We hypothesized that omphalocele is the result of an arrest in the secondary abdominal wall development and predicted that we would observe delays in myoblast maturation and an arrest in secondary abdominal wall development. To look for evidence in support of our hypothesis, we performed a histological analysis of normal human abdominal wall development and compared this to mouse. We also conducted the first histological analysis of two human specimens with omphalocele. In these two omphalocele specimens, secondary abdominal wall development appears to have undergone an arrest around Carnegie Stage 19. "
More recent papers
Mark Hill.jpg
PubMed logo.gif

This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Muscle Development Timeline

Francesca Soncin, Marwa Khater, Cuong To, Donald Pizzo, Omar Farah, Anna Wakeland, Kanaga Arul Nambi Rajan, Katharine K Nelson, Ching-Wen Chang, Matteo Moretto-Zita, David R Natale, Louise C Laurent, Mana M Parast Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development: 2018; PubMed 29361559

Mehari Endale, Shawn Ahlfeld, Erik Bao, Xiaoting Chen, Jenna Green, Zach Bess, Matthew Weirauch, Yan Xu, Anne Karina Perl Dataset on transcriptional profiles and the developmental characteristics of PDGFRα expressing lung fibroblasts. Data Brief: 2017, 13;415-431 PubMed 28702480

Yifei Yao, Lucas Xian Da Ong, Xiaotong Li, Kinlun Wan, Arthur F T Mak Effects of Biowastes Released by Mechanically Damaged Muscle Cells on the Propagation of Deep Tissue Injury: A Multiphysics Study. Ann Biomed Eng: 2016; PubMed 27624658

Yuting Ling, Chunhui Li, Kairui Feng, Robyn Duncan, Roos Eisma, Zhihong Huang, Ghulam Nabi Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE). J Biomech: 2016; PubMed 26903410

Adam K Walker, Krista J Spiller, Guanghui Ge, Allen Zheng, Yan Xu, Melissa Zhou, Kalyan Tripathy, Linda K Kwong, John Q Trojanowski, Virginia M-Y Lee Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathol.: 2015; PubMed 26197969

Muscle Types

Fibre Type Type I fibres Type II a fibres Type II x fibres Type II b fibres
Contraction time Slow Moderately Fast Fast Very fast
Size of motor neuron Small Medium Large Very large
Resistance to fatigue High Fairly high Intermediate Low
Activity Used for Aerobic Long-term anaerobic Short-term anaerobic Short-term anaerobic
Maximum duration of use Hours <30 minutes <5 minutes <1 minute
Power produced Low Medium High Very high
Mitochondrial density High High Medium Low
Capillary density High Intermediate Low Low
Oxidative capacity High High Intermediate Low
Glycolytic capacity Low High High High
Major storage fuel Triglycerides Creatine phosphate, glycogen Creatine phosphate, glycogen Creatine phosphate, glycogen
Myosin heavy chain,
human genes
MYH7 MYH2 MYH1 MYH4


Muscle Fibre Type 
Fibre Type Type I fibres Type II a fibres Type II x fibres Type II b fibres
Contraction time Slow Moderately Fast Fast Very fast
Size of motor neuron Small Medium Large Very large
Resistance to fatigue High Fairly high Intermediate Low
Activity Used for Aerobic Long-term anaerobic Short-term anaerobic Short-term anaerobic
Maximum duration of use Hours <30 minutes <5 minutes <1 minute
Power produced Low Medium High Very high
Mitochondrial density High High Medium Low
Capillary density High Intermediate Low Low
Oxidative capacity High High Intermediate Low
Glycolytic capacity Low High High High
Major storage fuel Triglycerides Creatine phosphate, glycogen Creatine phosphate, glycogen Creatine phosphate, glycogen
Myosin heavy chain,
human genes
MYH7 MYH2 MYH1 MYH4
Links: Muscle Development | Muscle Development Timeline

Abdominal Wall

The data below is from a recent analysis of human and mouse abdominal wall development.[1] Using the human Kyoto Collection embryos.

Abdominal Wall Development
Human Mouse
Carnegie stage days
14 E33 E10.5
17 E42 E11.5
18 E44 E12.5
21 E54 E14.5
23 E58 E15.5


Mouse E Days
Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E18.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline

Human Detailed

Abdominal Wall Muscle Timeline
Carnegie Stage Day Mouse Event
14 33 E10.5 mesoderm of primary body wall non-compact, coalesced in the ventral midline to create the abdominal cavity. Liver and stomach present. Dermomyotomes that are derived from somites have been formed.
16 40 Migration distance about 25% of the hemicircumference of the abdominal cavity. Lateral plate mesoderm has become more condensed and thicker in the area around the myoblasts. Primary abdominal wall ventral to this region was thinner and less dense. Suggests both myoblasts and connective tissue may migrate into the primary body wall or active cell proliferation.
17 42 E11.5 cells now migrated about 50% of the distance to the ventral midline. Inner and outer layers not yet not discernible.
18 44 E12.5 Separation of myoblasts into distinct inner and outer layers. Myoblasts in both inner and outer layers began to exhibit unidirectional orientation. Abdominal wall thicker (500 μm) in region where secondary structures forming compared with primary body wall region (260 μm). More dorsally positioned regions, outermost layer of connective tissue comprised approximately half of this thickness.
19 48 Segregation of the myoblasts into four distinct muscle groups with unidirectional orientation of myoblasts. Myoblasts migrated over half of the distance to the ventral midline. Abdominal wall remains thickest in the area where the muscles migrated and again the outermost layer of connective tissue comprises approximately half of the total thickness of the abdominal wall in this region. Primary abdominal wall that is ventral to the migrating myoblasts noticeably thinner. Human rectus completely separated after migrating over half the distance to the midline. In mouse, the rectus is not segregated from the other muscles until reaching the midline.
21 54 E14.5 Myoblasts have reached the ventral midline and myotubes were present and oriented uniformly within all muscle groups. Rectus abdominis formed distinct bundles of muscle indicating that development and differentiation of this muscle were more prominent in humans than in mice. Connective tissue layers form majority of the thickness of the abdominal wall, outermost layer of connective tissue majority of thickness.
23 58 E15.5 Rectus muscle forms 2 or 3 distinct layers and myotube orientation remained uniform in all muscles. External oblique and internal oblique expand in terms of thickness. Transversus remained a thin layer of muscle. Thickness of the connective tissue was reduced. The orientation of connective tissue layers in the obliques and transversus abdominis was dorsal to ventral.
Table Data[1]


International Classification of Diseases - XVII Congenital Malformations - Q79 Congenital malformations of the musculoskeletal system - Q79.2 Exomphalos Omphalocele Excl.: umbilical hernia (K42.-)


Links: Timeline human development | Omphalocele

Historic Limb Data

Manual of Human Embryology by Franz Keibel and Franklin P. Mall (1910)

Upper Limb

Lower Limb

Hip

Links: Musculoskeletal System - Abnormalities


Prenatal

Birth

Postnatal

Mouse Limb Muscle

Mouse limb tissue development.jpg

Change in cell types and tissue formation as a function of mouse developmental stage.[2]


Links: Mouse Development

References

  1. 1.0 1.1 1.2 Nichol PF, Corliss RF, Yamada S, Shiota K & Saijoh Y. (2012). Muscle patterning in mouse and human abdominal wall development and omphalocele specimens of humans. Anat Rec (Hoboken) , 295, 2129-40. PMID: 22976993 DOI.
  2. Leila Taher, Nicole M Collette, Deepa Murugesh, Evan Maxwell, Ivan Ovcharenko, Gabriela G Loots Global gene expression analysis of murine limb development. PLoS ONE: 2011, 6(12);e28358 PubMed 22174793


Reviews


Articles


Search PubMed

Search Pubmed: Abdominal Wall Development

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Terms

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link



Cite this page: Hill, M.A. (2018, December 9) Embryology Musculoskeletal System - Muscle Development Timeline. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Muscle_Development_Timeline

What Links Here?
© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G