Harvard Collection

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Harvard Collection

Harvard collection storage cabinet[1]
Charles Sedgwick Minot (1852–1914)

This historic collection of human and other embryos was originally collected by Charles Minot (1852–1914), sometimes referred to as the Minot Collection, now forms part of the larger Carnegie Collection. The collection was described in detail by Minot (1905).[1]

Embryos in the collection are numbered and prefixed in papers by the acronym H.E.C..


Carnegie Collection - HDAC 7 Charles Sedgwick Minot Embryological Collection

  • Embryos from the Harvard School of Medicine, as well as drawings and photographs of the embryos.
  • A large collection of reprints, printed lectures, class syllabi, and theses on embryology and related topics.
  • The reprint collection was started by Charles S. Minot (1852-1914) in the 1800s and added to through the 1960s.
  • The reprint collection also includes personal papers and research notes from Charles Wislocki.


"These considerations have led us to adopt a metal cabinet, which has been specially devised for our needs. It is made of sheet tin in such a manner that the trays are very compact, are absolutely interchangeable, an intake up a minimum amount of room. The construction adopted is such that the tendency to warp is entirely done away with (Fig.3) The trays are all japanned so that they do not rust, and we slip a bit of white paper into each tray to make a background for the sections. Each tray is, moreover, furnished with a litle label holder, and they are put together in cabinets of thirty trays each, the trays themselves being of such a size that they will hold twenty-four of the ordinary slides, three inches by one. Moreover, the cabinets themselves are so devised that they can be stacked one on top of another, taking up a minimum amount of room. We devote a vertical column of these cabinets to a species, and simply interpolate from time to time a new cabinet in the column as the growth of the collection may render necessary. The cabinets are made by Peter Gray & Co., of Union street, Boston, and are now kept in stock by several of the dealers in microscopical supplies in this country. They cost only a trifle more than the wooden cabinets, and are, according to our trial of them, certainly to be preferred to any other form of cabinet which we have tested." (Text fromThe Harvard Embryological Collection (1905)[1])


Links: 1905 The Harvard Embryological Collection | Charles Minot | Category:Harvard Collection


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Harvard Collection Catalogue

Human

Many of the collection's human embryos were used by Frederic T. Lewis in his chapter on gastrointestinal tract development in Keibel and Mall's 1912 Human embryology textbook.[2]



Length Age Transverse Sagittal Frontal
1.0 835
4.0 714
7.5 256
8.0 817
9.2-9.4 529
734
10.2-11.5 189 736
12.0 817
818
13.6 839
19.0 819
21.0 744
21.8-24.0 B. 38
192
181 H. 24
29.0 871 851 852
914
32.0 H. 648
B. 649
193
H. 290
292
194
H. 291
37.0 820
42.0 B. 838
H. 841
78.0 3 mos 722
723
724
720
721
  • 818 - yolk sack only.
  • 192 - yolk sack only.
  • 193 - left foot.
  • 194 - right foot.
  • 720 - Face only.
  • 721 - Vertex of head.
  • 722 - Neck and base of head.
  • 723 - Thorax.
  • 725 - Abdomen.
  • 728 - Penis only.
  • 729 - Finger only.
  • 730 - Toe only.
  • 727 - Head horizontal.



Links: Catalogue Table | 1905 The Harvard Embryological Collection

Harvard Collection Embryos

Embryo 55

Harvard Embryo 55

Studied histochemically by Hertig et al. (1958)[3].

  • Hysterectomy.
  • Presumed age 13 days.
  • Chorion, 1.77 x 1.33 x 0.598 mm.
  • Chorionic cavity, 0.73 x 0.68 x 0.221 mm. Embryonic disc, 0.296 x 0.196 X 0.044 mm.

Chorionic villi essentially solid, with earliest suggestion of mesoblastic core formation. "Apparently without axial differentiation." Possesses "a very recently formed definitive (secondary) yolk sac." Possible primordial germ cells ("stuffed with glycogen") within endoderm near edge of disc.


Embryo 192

Harvard Embryo 192

Embryo 256

Harvard Embryo 256

Embryo 529

Harvard Embryo 529

Embryo 714

Harvard Embryo 714 published in a paper by Bremer (1906).[4]


Manual of Human Embryology II[2]

Keibel Mall 2 267.jpg Fig. 267. — Transverse sections of the epithelial tube of the oesophagus. X 160 diam.

Fig. 293. Sections showing the formation of the periportal ducts (D.peri-p.) around a branch of the portal vein (V.p.). A from an embryo of 22.8 mm. (Harvard Collection, Series 871).

Embryo 825

Harvard Embryo 825

Embryo 838

Harvard Embryo 838 human embryo 42 mm

Embryo 839

Harvard Embryo 839 human embryo 17.8 mm

See Thyng (1914)[5]

  • 17.8 mm Embryo, external appearance suggests Carnegie stage 19 embryo (Week 7, 48 - 51 days, 16 - 18 mm).


Links: 1914 Thyng 17.8 mm Embryo

Embryo 871

Harvard Embryo 871


Fig. 292. A section of the gall-bladder of a 29 mm embryo (Harvard Collection, Series 914). X 180 diam. B section of the common bile-duct of a 22.8 mm embryo (Harvard Collection, Series 871). X 180 diam. C epithelium of the gall-bladder, two weeks after birth. X 580 diam.

Embryo 913

Harvard Embryo 913 human embryo 32 mm.


Fig. 293. Sections showing the formation of the periportal ducts around a branch of the portal vein. B from an embryo of 32 mm (Harvard Collection, Series 913). X 185 diam.


Embryo 914

Harvard Embryo 914


Keibel Mall 2 292.jpg

Fig. 292. A section of the gall-bladder of a 29 mm embryo (Harvard Collection, Series 914). X 180 diam.


Embryo 1000

Harvard Embryo 1000 human embryo 10 mm

Keibel Mall 2 274.jpg Fig. 274. Sections of the stomach of a 10 mm embryo (Harvard Collection, Series 1000). A, through the cardia. B, through the fundus. C, through the pylorus. A. coel., coeliac artery ; A.g.s., left gastric artery ; A. hep., hepatic artery ; Alien., splenic artery ; Ao., aorta ; B.om., omental bursa ; C.W., Wolffian body ; D.ch., common bile-duct ; D.v., ductus venosus ; F.ep., foramen epiploicum ; N.sym., sympathetic nerve ; O.ma., greater omentum ; O.mi., lesser omentum ; Pul., lung ; Va., vagus nerve ; V.p., portal vein ; V.8., left suprarenal vein.
Keibel Mall 2 294.jpg Fig. 294. A hepatic trabecula containing a lumen. From a 10 mm embryo (Harvard Collection, Series 1000). X 1065 diam. B, bile-capillaries in a 44.3 mm embryo (Harvard Collection, Series 1611). x 1065 diam. Bl., blood-corpuscle; C.hep., hepatic cell; Endo., endothelium ; Lum., lumen of a bile capillary.


Embryo 1005

Harvard Embryo 1005

Embryo 1129

Harvard Embryo 1129

Embryo 1322

Harvard Embryo 1322 Human embryo 16 mm


Fig. 311. Section through the stomach, pancreas, and a part of the liver, from an embryo of 16 mm. (Harvard Collection, Series 1322). y>X 40 diam. ; ,A. mes. sup., superior mesenteric artery; tB. oment., omental bursa ;'_Gaster, stomach; Lien, spleen; V. p., portal vein. (Other labels as in preceding figures.)

Embryo 2051

Harvard Embryo 2051 Human embryo 15 mm


Embryo 2128

Harvard Embryo 2128 Human embryo 45 mm

McClure1925 fig16.jpg

Fig. 16. Human embryo 45 mm Harvard Collection, no. 2128[6]

Harvard Collection Papers

Pharynx

Kingsbury BF. The development of the human pharynx. (1915) Amer. J Anat. 18(3): 329-397.

Venous System

Published by McClure (1925).[6]

  • No. 2051, 15 mm embryo (reconstructed x 100)
  • No. 1913, 18 mm embryo (reconstructed by Huntington and McClure in 1915)
  • No. 2924, 25 mm embryo
  • No. 2128, 45 mm embryo (reconstructed x 50)


References

  1. 1.0 1.1 1.2 Minot CS. The Harvard embryological collection. (1905) J Med Res. Aug;13(5):499-522.1. PMID 19971684 | PMC2099155 | PDF
  2. 2.0 2.1 Keibel F. and Mall FP. Manual of Human Embryology II. (1912) J. B. Lippincott Company, Philadelphia.
  3. Hertig AT. Adams EC. Mckay DG. Rock J. Mulligan WJ. and Menkin MF. A thirteen-day human ovum studied histochemically. (1958) Am. J. Obstet. Gynecol., 76(5): 1025-40. PMID 13583048
  4. Bremer JL. Description of a 4-mm human embryo. (1906) Amer. J Anat. 5: 459-480.
  5. Thyng FW. The anatomy of a 17.8 mm human embryo. (1914) Amer. J Anat. 17: 31-112.
  6. 6.0 6.1 McClure CFW. and Butler EG. The development of the vena cava inferior in man. (1925) Amer. J Anat. 35(3): 331-383.


External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

  • National Academy of Sciences Biographical Memoirs Charles Minot (1920)



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Cite this page: Hill, M.A. (2018, December 13) Embryology Harvard Collection. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Harvard_Collection

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G