Harvard Collection

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Harvard Collection

Harvard collection storage cabinet[1]
Charles Sedgwick Minot (1852–1914)

This historic collection of human and other embryos was originally collected by Charles Minot (1852–1914), sometimes referred to as the Minot Collection, now forms part of the larger Carnegie Collection. The collection was described in detail by Minot (1905).[1]

Embryos in the collection are numbered and prefixed in papers by the acronym H.E.C..


Carnegie Collection - HDAC 7 Charles Sedgwick Minot Embryological Collection

  • Embryos from the Harvard School of Medicine, as well as drawings and photographs of the embryos.
  • A large collection of reprints, printed lectures, class syllabi, and theses on embryology and related topics.
  • The reprint collection was started by Charles S. Minot (1852-1914) in the 1800s and added to through the 1960s.
  • The reprint collection also includes personal papers and research notes from Charles Wislocki.


"These considerations have led us to adopt a metal cabinet, which has been specially devised for our needs. It is made of sheet tin in such a manner that the trays are very compact, are absolutely interchangeable, an intake up a minimum amount of room. The construction adopted is such that the tendency to warp is entirely done away with (Fig.3) The trays are all japanned so that they do not rust, and we slip a bit of white paper into each tray to make a background for the sections. Each tray is, moreover, furnished with a litle label holder, and they are put together in cabinets of thirty trays each, the trays themselves being of such a size that they will hold twenty-four of the ordinary slides, three inches by one. Moreover, the cabinets themselves are so devised that they can be stacked one on top of another, taking up a minimum amount of room. We devote a vertical column of these cabinets to a species, and simply interpolate from time to time a new cabinet in the column as the growth of the collection may render necessary. The cabinets are made by Peter Gray & Co., of Union street, Boston, and are now kept in stock by several of the dealers in microscopical supplies in this country. They cost only a trifle more than the wooden cabinets, and are, according to our trial of them, certainly to be preferred to any other form of cabinet which we have tested." (Text fromThe Harvard Embryological Collection (1905)[1])


Links: 1905 The Harvard Embryological Collection | Charles Minot | Category:Harvard Collection


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Harvard Collection Catalogue

Human

Many of the collection's human embryos were used by Frederic T. Lewis in his chapter on gastrointestinal tract development in Keibel and Mall's 1912 Human embryology textbook.[2]



Length Age Transverse Sagittal Frontal
1.0 835
4.0 714
7.5 256
8.0 817
9.2-9.4 529
734
10.2-11.5 189 736
12.0 817
818
13.6 839
19.0 819
21.0 744
21.8-24.0 B. 38
192
181 H. 24
29.0 871 851 852
914
32.0 H. 648
B. 649
193
H. 290
292
194
H. 291
37.0 820
42.0 B. 838
H. 841
78.0 3 mos 722
723
724
720
721
  • 818 - yolk sack only.
  • 192 - yolk sack only.
  • 193 - left foot.
  • 194 - right foot.
  • 720 - Face only.
  • 721 - Vertex of head.
  • 722 - Neck and base of head.
  • 723 - Thorax.
  • 725 - Abdomen.
  • 728 - Penis only.
  • 729 - Finger only.
  • 730 - Toe only.
  • 727 - Head horizontal.



Links: Catalogue Table | 1905 The Harvard Embryological Collection

Harvard Collection Embryos

Embryo 55

Harvard Embryo 55

Studied histochemically by Hertig et al. (1958)[3].

  • Hysterectomy.
  • Presumed age 13 days.
  • Chorion, 1.77 x 1.33 x 0.598 mm.
  • Chorionic cavity, 0.73 x 0.68 x 0.221 mm. Embryonic disc, 0.296 x 0.196 X 0.044 mm.

Chorionic villi essentially solid, with earliest suggestion of mesoblastic core formation. "Apparently without axial differentiation." Possesses "a very recently formed definitive (secondary) yolk sac." Possible primordial germ cells ("stuffed with glycogen") within endoderm near edge of disc.


Embryo 192

Harvard Embryo 192

Embryo 256

Harvard Embryo 256

Embryo 529

Harvard Embryo 529

Embryo 714

Harvard Embryo 714 published in a paper by Bremer (1906).[4]


Manual of Human Embryology II[2]

Keibel Mall 2 267.jpg Fig. 267. — Transverse sections of the epithelial tube of the oesophagus. X 160 diam.

Fig. 293. Sections showing the formation of the periportal ducts (D.peri-p.) around a branch of the portal vein (V.p.). A from an embryo of 22.8 mm. (Harvard Collection, Series 871).


Keibel Mall 2 300.jpg

Fig. 300 Dorsal views of the hepatic region

Embryo 787

Harvard Embryo 787 Human embryo 22.8 mm[5]

Fig. 10. Photomicrograph x50 H.E.C. Embryo 787, length 22.8 mm., slide 406. Transverse section shows the recess between pubis and ischium to form the acetabular fossa. In it are seen the origins of the ligamentum teres and the Haversian gland. The anteversion of the neck of the femur has developed to produce an angle of 30° to the midline of the embryo. The ligamentum teres develops in situ without formation of a groove in the head of the femur. Short rotator muscles of the hip are well outlined.



Embryo 816

Harvard Embryo 816 human embryo 12.0 mm

Embryo 825

Harvard Embryo 825

Embryo 828

Harvard Embryo 828 human embryo 19.0 mm

Embryo 838

Harvard Embryo 838 human embryo 42 mm

Embryo 839

Harvard Embryo 839 human embryo 17.8 mm

See Thyng (1914)[6]

  • 17.8 mm Embryo, external appearance suggests Carnegie stage 19 embryo (Week 7, 48 - 51 days, 16 - 18 mm).


Links: 1914 Thyng 17.8 mm Embryo

Embryo 871

Harvard Embryo 871


Fig. 292. A section of the gall-bladder of a 29 mm embryo (Harvard Collection, Series 914). X 180 diam. B section of the common bile-duct of a 22.8 mm embryo (Harvard Collection, Series 871). X 180 diam. C epithelium of the gall-bladder, two weeks after birth. X 580 diam.

Embryo 913

Harvard Embryo 913 human embryo 32 mm.


Fig. 293. Sections showing the formation of the periportal ducts around a branch of the portal vein. B from an embryo of 32 mm (Harvard Collection, Series 913). X 185 diam.


Embryo 914

Harvard Embryo 914


Keibel Mall 2 292.jpg

Fig. 292. A section of the gall-bladder of a 29 mm embryo (Harvard Collection, Series 914). X 180 diam.

Embryo 918

Harvard Embryo 918 Human embryo 28.8 mm[5]

Fig. 8. Photomicrograph X30 H.E.C. Embryo 918, length 30 mm., slide 1094. Same embryo as Fig. 7. Blastema in the anterior limb of the Y between pubis and ilium is seen. Note location of ossification center in ilium as opposed to nucleus of chondrification near acetabulum in Figs. 3 and 6. Course of ligamentum teres from transverse ligament to fovea is prominent. The glenoid labrum and relationship of the capsule may be seen. Symphysis pubis is approximating.


Embryo 939

Harvard Embryo 939 human embryo 13.6 mm

Embryo 1000

Harvard Embryo 1000 human embryo 10 mm

Keibel Mall 2 274.jpg Fig. 274. Sections of the stomach of a 10 mm embryo (Harvard Collection, Series 1000). A, through the cardia. B, through the fundus. C, through the pylorus. A. coel., coeliac artery ; A.g.s., left gastric artery ; A. hep., hepatic artery ; Alien., splenic artery ; Ao., aorta ; B.om., omental bursa ; C.W., Wolffian body ; D.ch., common bile-duct ; D.v., ductus venosus ; F.ep., foramen epiploicum ; N.sym., sympathetic nerve ; O.ma., greater omentum ; O.mi., lesser omentum ; Pul., lung ; Va., vagus nerve ; V.p., portal vein ; V.8., left suprarenal vein.
Keibel Mall 2 294.jpg Fig. 294. A hepatic trabecula containing a lumen. From a 10 mm embryo (Harvard Collection, Series 1000). X 1065 diam. B, bile-capillaries in a 44.3 mm embryo (Harvard Collection, Series 1611). x 1065 diam. Bl., blood-corpuscle; C.hep., hepatic cell; Endo., endothelium ; Lum., lumen of a bile capillary.

Embryo 1003

Template:Ref-Kingsbury1915

Fig. 7 Outline drawing of section #228, 14.5 mm. human embryo (No. 1003, Harvard Collection). X 10.


Embryo 1005

Harvard Embryo 1005

Embryo 1129

Harvard Embryo 1129

Embryo 1322

Harvard Embryo 1322 Human embryo 16 mm


Fig. 311. Section through the stomach, pancreas, and a part of the liver, from an embryo of 16 mm. (Harvard Collection, Series 1322). y>X 40 diam. ; ,A. mes. sup., superior mesenteric artery; tB. oment., omental bursa ;'_Gaster, stomach; Lien, spleen; V. p., portal vein. (Other labels as in preceding figures.)

Embryo 1597

Harvard Embryo 1597 Human embryo 19.3 mm[5]

Fig. 5. Photomicrograph X30 H.E.C. Embryo 1597, length 19.3 mm., slide 807. The center of the femur shows mature fetal cartilage. An angulation of the upper end delineates the neck which forms an angle of 60° to the midline and 160° to the shaft. Note the cell distribution in transverse lines between neck and shaft. The joint region is densely stained.

Embryo 1598

Harvard Embryo 1598 Human embryo 28.8 mm[5]

Fig. 9. Photomicrograph X55 H.E.C. Embryo 1598, length 28.8 mm., slide 218. Sagittal section through the medial wall of the acetabulum shows the relative proportion of ischial and pubic attachments of the ligamentum teres, and the region of the acetabular fossa. At this stage the Y-shaped junction is not present, as fusion in cartilage has already taken place. This cartilage is that which will outline the Y in the child when the centers of ossification of the pelvic bones approximate the acetabulum. Thus we see the Y duplicated in both blastema and cartilage at different stages, although the points of origin of chondrification and ossification are not the same in the pelvic bones as they are in the femur.


Embryo 1707

Template:Ref-Kingsbury1915

Fig. 8 Outline drawing of section #457, 16.4 mm. human embryo, (No. 1707, Harvard Collection). X 10.

Embryo 1913

Harvard Embryo 1913 Human embryo 18 mm

(reconstructed by Huntington and McClure in 1915)

Embryo 2046

Harvard Embryo 2046 Human embryo 23 mm[5]

Fig. 6. Photomicrograph x21 H.E.C. Embryo 2046, length 23 mm., slide 1606. The line of the joint is a zone of diminished density. The femur is becoming adducted to an angle of 30-40° with the midline. The neck appears longer and is more angulated on the shaft, 65-70° to the midline and 150-155° to the shaft. The false pelvis with the anterior superior spine of the ilium is shown as a projection of precartilage.

Embryo 2050

Harvard Embryo 2050 Human embryo 36 mm[5]

Fig. 12. Photomicrograph x 140 H.E.C. Embryo Template:HEC2050, length 36 mm., slide 2531. High power of space in Fig. 11. In the spaces float cells possessing normal-appearing nuclei and long fibrils. There are smaller cells with pyknotic nuclei as well as fragmented material suggesting shadows of nuclei. The spaces appear under the ligamentum teres, between it and the head of the femur and within the capsule distal to the glenoid labrum.


Embryo 2051

Harvard Embryo 2051 Human embryo 15 mm[7]


Embryo 2059

Harvard Embryo 2059 Human embryo 36 mm[5]

Fig, 11. Photomicrograph x20 H.E.C. Embryo 2059, length 36 mm., slide 2531. Spaces are shown appearing in the tissue about the head of the femur. All the elements of the joint are defined. The acetabulum, glenoid labrum, and transverse acetabular ligament form 180° of a circle. Blood vessels are present in perichondrium, joint capsule, ligamentum teres, and Haversian gland, but none 1s present in the cartilage or shaft of the bones.

Embryo 2128

Harvard Embryo 2128 Human embryo 45 mm

McClure1925 fig16.jpg

Fig. 16. Human embryo 45 mm Harvard Collection, no. 2128[7]


Embryo 2155

Harvard Embryo 2155 Human embryo 17.5 mm[5]

Fig. 4. Photomicrograph x30 H.E.C. Embryo 2155, length 17.5 mm., slide 1169. A mass of deeply staining cells marks the joint. Muscle groups are outlined, some converge at a projection of blastema, locating the great trochanter. The femur, covered with perichondrium shows cartilage cells shrinking from matrix at the center and arcuate columns of precartilage cells compose the ends. The elements of the innominate primordia may be identified.


Embryo 2924

Harvard Embryo 2924 Human embryo 25 mm[7]

Harvard Collection Papers

Pharynx

Template:Ref-Kingsbury1915

Venous System

Published by McClure (1925).[7]

  • No. 2051, 15 mm embryo (reconstructed x 100)
  • No. 1913, 18 mm embryo (reconstructed by Huntington and McClure in 1915)
  • No. 2924, 25 mm embryo
  • No. 2128, 45 mm embryo (reconstructed x 50)

Embryo 2300

Harvard Embryo 2300 Human embryo 6.75 mm[5]

Fig. 1. Photomicrograph x55 H.E.C. Embryo 2300, length 6.75 mm., slide 420. The limb bud is formed. Its relation to the somites, coelom, Wolffian ducts are shown. The cells are indistinguishable from each other, except for the many mitoses. From this period on the limb bud is a distinct entity and displacement caudally and laterally occurs simultaneously with elongation of the embryo as a whole.


References

  1. 1.0 1.1 1.2 Minot CS. The Harvard embryological collection. (1905) J Med Res. Aug;13(5):499-522.PMID 19971684 | PDF
  2. 2.0 2.1 Keibel F. and Mall FP. Manual of Human Embryology II. (1912) J. B. Lippincott Company, Philadelphia.
  3. Hertig AT. Adams EC. Mckay DG. Rock J. Mulligan WJ. and Menkin MF. A thirteen-day human ovum studied histochemically. (1958) Am. J. Obstet. Gynecol., 76(5): 1025-40. PMID 13583048
  4. Bremer JL. Description of a 4-mm human embryo. (1906) Amer. J Anat. 5: 459-480.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Strayer MMJr. The embryology of the human hip joint. (1943) Yale J Biol. Med. 16(1): 13–26.6. PMCID: PMC2601352
  6. Thyng FW. The anatomy of a 17.8 mm human embryo. (1914) Amer. J Anat. 17: 31-112.
  7. 7.0 7.1 7.2 7.3 McClure CFW. and Butler EG. The development of the vena cava inferior in man. (1925) Amer. J Anat. 35(3): 331-383.


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  • National Academy of Sciences Biographical Memoirs Charles Minot (1920)



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Cite this page: Hill, M.A. (2024, March 19) Embryology Harvard Collection. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Harvard_Collection

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