Carnegie stage 3

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Introduction

Human embryo day 5 label2.jpg

Human blastocyst (day 5) still within zone pellucida.

The free-floating blastocyst has reached the uterine body still enclosed in the zone pellucida and "hatches" from this surrounding extracellular matrix.

It is only after hatching that the blastocyst can attach to and then implant into the uterine wall.

Summary

See also Events


Links: Week 1 | Blastocyst | Lecture | Medicine Practical | Science Practical | Trophoblast | Stage 4



Human embryo day 5 label.jpg Stage 3 Day 5
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Blastocyst Hatching

CSt3.jpg Human Blastocyst "hatching" from zona pellucida (classified as Carnegie stage 3).

Blastocyst is too the right of image and zona pellucida is shown to the left of the image.

  • small opening in the zona pellucida through which the blastocyst is hatching.
  • flattened trophoblast cells forming the outer cell layer of the blastocyst.
  • inner cell mass shown in the centre of the image and on the left-hand wall of the blastocyst.
  • blastocoel forming a large fluid-filled space within the blastocyst.


Human Blastocyst (day 3 to 6)
Human-blastocyst-day-3-6-icon.jpg
 ‎‎Day 3 to 6
Page | Play
Human blastocyst day 5-6.jpg
 ‎‎Contractions
Page | Play
Human blastocyst hatching movie icon.jpg
 ‎‎Hatching
Page | Play

Histiotrophic Nutrition

Term used to describe in early placenta development the intital transfer of nutrition from maternal to embryo (histiotrophic nutrition) compared to later blood-borne nutrition (hemotrophic nutrition). Histotroph is the nutritional material accumulated in spaces between the maternal and fetal tissues, derived from the maternal endometrium and the uterine glands. This nutritional material is absorbed by phagocytosis initially by blastocyst trophectoderm and then by trophoblast of the placenta. in later placental development nutrition is by the exchange of blood-borne materials between the maternal and fetal circulations, hemotrophic nutrition.

Reference

Graham J Burton, Adrian L Watson, Joanne Hempstock, Jeremy N Skepper, Eric Jauniaux Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J. Clin. Endocrinol. Metab.: 2002, 87(6);2954-9 PubMed 12050279


Carnegie Collection

Stage3 bf01.jpg Stage3 bf02.jpg
58 cell blastocyst (day 4) (No. 8794) 107 cell blastocyst (day 4.5) (No. 8663)
iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Events

  • Mitosis - blastomere cells divide by mitosis, without growth between divisions. initially at the same time (synchronous) but with each round at slightly different times (asynchronous)
  • Blastocyst - a fluid-filled cavity develops within the cell mass.


References


Additional Images

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline



Cite this page: Hill, M.A. 2017 Embryology Carnegie stage 3. Retrieved September 26, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_3

What Links Here?
© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G