Blastocyst Day 3-6 Movie

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<html5media height="470" width="500">File:Human_blastocyst_day_3-6.mp4</html5media> Click Here to play on mobile device

Movie shows in vitro development of a human morula to blastocyst stage occurring between day 3 and day 6 post-fertilization. Timing shown below are "movie times" not the "developmental days". 00:00 day 3 - Initially a solid mass of cells morula stage enclosed by the zona pellucida. 00:18 day 4 - blastocoel formation 00:22 - inner cell mass (embryoblast) 00:29 - maximal expansion of blastocyst in ZP 00:31 - contraction 00:32 - re-expansion 00:37 day 5 - contraction 00:38 - re-expansion 00:39 - contraction (collapse) 00:40 - re-expansion (blastocoel enlargement) 00:41 - commence blastocyst hatching (1 o'clock position) 00:44 day 6 - complete hatching, blastocyst expansion (inner cell mass 2 o'clock position) 00:47 - trophoblast layer thickens 00:53 movie finishes Blastocyst Movie Links: MP4 day 3-6 | Blastocyst Day 5-6 Movie | MP4 day 5-6 | Blastocyst Hatching Movie | MP4 Hatching day 5-6 | blastocyst | Movies Carnegie stage 3 | Carnegie stage 4 | Carnegie stage 5

Human blastocyst development (in vitro) from day 1 to day 6. Day 1 - zygote, the first diploid cell. Day 2 - 2 then 4 blasomeres, the first cells formed by mitotic cell division. Day 3 - morula. Day 4 - compacting morula. Day 5 - blastocyst. Day 6 - hatching blastocyst from zona pellucida shell, after this event the blastocyst can now attach and implant into the uterine wall. Links: zygote | morula | blastocyst | Zona pellucida | implantation | Carnegie stage 3 | Carnegie stage 4 | Carnegie stage 5

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Reference

<pubmed>20890283</pubmed>| Nat Biotechnol.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nat Biotechnol. (Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Pera RA. Nat Biotechnol. 2010 Oct 3. [Epub ahead of print] PMID 20890283), copyright (2010)

Licensee: Mark A Hill License Date: Oct 06, 2010 License Number: 2523401420894 Publication: Nature Biotechnology Title: Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Type Of Use: Web Site