Abnormal Development - Syphilis
|Embryology - 4 Aug 2021 Expand to Translate|
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The variety of bacterial infections that can occur during pregnancy is as variable as the potential developmental effects, from virtually insignificant to major developmental, abortive or fatal in outcome. Some bacteria are common and are part of the normal genital tract flora (Lactobacillus sp), while other bacterial infections are less common or even rare and initially infect/transmit by air or fluids through the different epithelia (genital tract, lungs, gastrointestinal tract). The genitally transmitted common sexually transmitted diseases (STDs) are the bacterial infections described as syphilis and gonorrhoea.
In the USA before 1989, reported cases of congenital syphilis (CS) were defined and classified on the basis of a set of clinical and serologic features known as the "Kaufman criteria". In 1988, the CDC developed a new surveillance case definition "All infants born to mothers who have untreated or inadequately treated syphilis are considered potentially infected. (This criterion is based on the 70%-100% chance that during the first 4 years of infection, an untreated woman will transmit syphilis to her unborn baby)."
|Bacterial Links: bacterial infection | syphilis | gonorrhea | tuberculosis | listeria | salmonella | TORCH | Environmental | Category:Bacteria|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
- Bacteria; Spirochaetes; Spirochaetes (class); Spirochaetales; Spirochaetaceae; Treponema; Treponema pallidum; Treponema pallidum subsp. pallidum;
The following information is based upon the 2003 CDC Surveillance Case Definition for Congenital Syphilis.
Congenital syphilis is an infant or child in whom Treponema pallidum is identified by darkfield microscopy, direct fluorescent antibody, or other specific stains in specimens from lesions, placenta, umbilical cord, or autopsy material.
Congenital syphilis is either of the following:
- A. any infant whose mother had untreated or inadequately treated1 syphilis at the time of delivery, regardless of the findings in the infant or child
- B. any infant or child who has a reactive treponemal test for syphilis and any one of the following:
- evidence of congenital syphilis on physical examination
- evidence of congenital syphilis on long bone X-ray
- reactive cerebrospinal fluid CSF-VDRL
- elevated CSF cell count or protein (without other cause)
- reactive test for IgM antibody.
Defined as a fetal death in which the mother had untreated or inadequately treated syphilis at the time of delivery of a fetus after a 20-week gestation or of a fetus weighing >500g.
Signs of Congenital Syphilis
|In an infant or a child younger than 2 years of age||In an older child|
The following data is based upon a table from a recent article by Jones and Jones (2010), reminding physicians to be aware of maternal and congenital syphilis.
The following data is based upon a table from a recent article by Jones and Jones (2010) reminding physicians to be aware of maternal and congenital syphilis.
Bacterial staining procedure named after Hans Christian Gram (1853 - 1938). Generally divides bacteria into either:
- Gram-positive bacteria purple crystal violet stain is trapped by layer of peptidoglycan (forms outer layer of the cell).
- Gram-negative bacteria outer membrane prevents stain from reaching peptidoglycan layer in the periplasm, outer membrane then permeabilized and pink safranin counterstain is trapped by peptidoglycan layer.
There is a chapter in the 1921 Contributions to Embryology publication Studies on Abortuses: A Survey of Pathologic Ova in the Carnegie Embryological Collection specifically related to syphilis.
Chapter 17. Changes Suggestive of Lues By A. W. Meyer
- "Since Schaudin's discovery, attention naturally has been directed very largely from placental lesions of syphilis to the presence of spirochsetse. But unfortunately the hope that the presence of this organism would form not only a crucial but also an infallible criterion for the determination of fetal lues does not seem to have been realized. The search for spirochsetee seems to have been attended by such uncertain results that a routine examination of the placenta has not even been recommended by prominent obstetricians."
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- Congenital Syphilis Case Investigation and Reporting Form Instructions PDF
- Rowe CR, Newberry DM & Jnah AJ. (2018). Congenital Syphilis: A Discussion of Epidemiology, Diagnosis, Management, and Nurses' Role in Early Identification and Treatment. Adv Neonatal Care , 18, 438-445. PMID: 30020089 DOI.
- Kittipornpechdee N, Hanamornroongruang S, Lekmak D & Treetipsatit J. (2018). Fetal and Placental Pathology in Congenital Syphilis: A Comprehensive Study in Perinatal Autopsy. Fetal Pediatr Pathol , 37, 231-242. PMID: 30207805 DOI.
- Rac MW, Bryant SN, McIntire DD, Cantey JB, Twickler DM, Wendel GD & Sheffield JS. (2014). Progression of ultrasound findings of fetal syphilis after maternal treatment. Am. J. Obstet. Gynecol. , 211, 426.e1-6. PMID: 24907700 DOI.
- Shahrook S, Mori R, Ochirbat T & Gomi H. (2014). Strategies of testing for syphilis during pregnancy. Cochrane Database Syst Rev , , CD010385. PMID: 25352226 DOI.
- Blencowe H, Cousens S, Kamb M, Berman S & Lawn JE. (2011). Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality. BMC Public Health , 11 Suppl 3, S9. PMID: 21501460 DOI.
- Zhu L, Qin M, Du L, Xie RH, Wong T & Wen SW. (2010). Maternal and congenital syphilis in Shanghai, China, 2002 to 2006. Int. J. Infect. Dis. , 14 Suppl 3, e45-8. PMID: 20137991 DOI.
- Jones IS & Jones AI. (2010). We keep forgetting maternal and congenital syphilis. Aust N Z J Obstet Gynaecol , 50, 306-7. PMID: 20618256 DOI.
Berman SM. (2004). Maternal syphilis: pathophysiology and treatment. Bull. World Health Organ. , 82, 433-8. PMID: 15356936
Carey JC. (2003). Congenital syphilis in the 21st century. Curr Womens Health Rep , 3, 299-302. PMID: 12844452
Ross SM. (1982). Sexually transmitted diseases in pregnancy. Clin Obstet Gynaecol , 9, 565-92. PMID: 6293753
Colombo DF, Lew JL, Pedersen CA, Johnson JR & Fan-Havard P. (2006). Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of Group B Streptococcus. Am. J. Obstet. Gynecol. , 194, 466-70. PMID: 16458647 DOI.
Nowicki S, Selvarangan R & Anderson G. (1999). Experimental transmission of Neisseria gonorrhoeae from pregnant rat to fetus. Infect. Immun. , 67, 4974-6. PMID: 10456962
Search NCBI Bookshelf: Medical Microbiology - Syphilis Search
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- CDC (USA)
- CDC Fact Sheet - STD and Pregnancy
- CDC Fact Sheet - Syphilis
- Congenital Syphilis Case Investigation and Reporting Form Instructions PDF
- Public Health Training Network Epidemiology and Prevention of Vaccine-Preventable Diseases (viewable Webcasts requires Media Player) | Advisory Committee on Immunization Practices (ACIP) Recommendations
- Medline Plus
- Office on Women's Health (USA) Fact Sheet - Syphilis
- Royal College of Obstetricians and Gynaecologists (UK) Infection and Pregnancy - study group recommendations (Jun 2001)
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Cite this page: Hill, M.A. (2021, August 4) Embryology Abnormal Development - Syphilis. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Syphilis
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G