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==Embryonic Human Renal Urothelial Branching Development==
==Embryonic Human Renal Urothelial Branching Development==


Renal Urothelial Branching Development at {{CS14}} and {{CS22}}.
Renal urothelial branching development in embryos between week 5 to 8 from the [[Kyoto Collection]] at carnegie stages: {{CS14}}, {{CS16}}, {{CS18}}, {{CS19}} and {{CS22}}. See also [[:File:Human embryonic renal branching stage 22.jpg|branching figure stage 22]].


Development of the metanephroses and urinary collecting system during embryonic periods. Numbers indicate Carnegie stage. Scale bar = 0.5 mm.
Development of the metanephroses and urinary collecting system during embryonic periods. Numbers indicate Carnegie stage. Scale bar = 0.5 mm.
{{Carnegie_stage_table_1}}
{{Renal Links}}


===Reference===
===Reference===
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Fig. 1. https://doi.org/10.1371/journal.pone.0203623.g001 Original figure resized, PMID added and converted to jpg format.
Fig. 1. https://doi.org/10.1371/journal.pone.0203623.g001 Original figure resized, PMID added and converted to jpg format.


PLoS One. 2018 Sep 7;13(9):e0203623. doi: 10.1371/journal.pone.0203623. eCollection 2018.
Branching morphogenesis of the urinary collecting system in the human embryonic metanephros.
Ishiyama H1, Ishikawa A1, Kitazawa H1, Fujii S1, Matsubayashi J1, Yamada S1,2, Takakuwa T1.
Author information
Abstract
An elaborate system of ducts collects urine from all nephrons, and this structure is known as the urinary collecting system (UCS). This study focused on how the UCS is formed during human embryogenesis. Fifty human embryos between the Carnegie stage (CS) 14 and CS23 were selected from the Kyoto Collection at the Congenital Anomaly Research Center of Kyoto University, Japan. Metanephroses, including the UCS, were segmented on serial digital virtual histological sections. Three-dimensional images were computationally reconstructed for morphological and quantitative analyses. A CS timeline was plotted. It consisted of the 3-D structural morphogenesis of UCS and quantification of the total amount of end-branching, average and maximum numbers of generations, deviation in the metanephros, differentiation of the urothelial epithelium in the renal pelvis, and timing of the rapid expansion of the renal pelvis. The first UCS branching generation occurred by CS16. The average branching generation reached a maximum of 8.74 ± 1.60 and was already the twelfth in CS23. The total end-branching number squared between the start and the end of the embryonic period. UCS would reach the fifteenth branching generation soon after CS23. The number of nephrons per UCS end-branch was low (0.21 ± 0.14 at CS19, 1.34 ± 0.49 at CS23), indicating that the bifid branching occurred rapidly and that the formation of nephrons followed after. The renal pelvis expanded mainly in CS23, which was earlier than that reported in a previous study. The number of nephrons connected to the UCS in the expanded group (246.0 ± 13.2) was significantly larger than that of the pre-expanded group (130.8 ± 80.1) (P < 0.05). The urothelial epithelium differentiated from the zeroth to the third generations at CS23. Differentiation may have continued up until the tenth generation to allow for renal pelvis expansion. The branching speed was not uniform. There were significantly more branching generations in the polar- than in the interpolar regions (P < 0.05). Branching speed reflects the growth orientation required to form the metanephros. Further study will be necessary to understand the renal pelvis expansion mechanism in CS23. Our CS-based timeline enabled us to map UCS formation and predict functional renal capacity after differentiation and growth.
PMID: 30192900 PMCID: PMC6128595 DOI: 10.1371/journal.pone.0203623


{{Footer}}
{{Footer}}
[[Category:Renal]]
[[Category:Renal]][[Category:Carnegie Stage 14]][[Category:Carnegie Stage 16]][[Category:Carnegie Stage 18]][[Category:Carnegie Stage 19]][[Category:Carnegie Stage 22]][[Category:Kyoto Collection]]

Latest revision as of 10:26, 18 January 2019

Embryonic Human Renal Urothelial Branching Development

Renal urothelial branching development in embryos between week 5 to 8 from the Kyoto Collection at carnegie stages: 14, 16, 18, 19 and 22. See also branching figure stage 22.

Development of the metanephroses and urinary collecting system during embryonic periods. Numbers indicate Carnegie stage. Scale bar = 0.5 mm.

Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Renal Links: renal | Lecture - Renal | Lecture Movie | urinary bladder | Stage 13 | Stage 22 | Fetal | Renal Movies | Stage 22 Movie | renal histology | renal abnormalities | Molecular | Category:Renal
Historic Embryology - Renal  
1905 Uriniferous Tubule Development | 1907 Urogenital images | 1911 Cloaca | 1921 Urogenital Development | 1915 Renal Artery | 1917 Urogenital System | 1925 Horseshoe Kidney | 1926 Embryo 22 Somites | 1930 Mesonephros 10 to 12 weeks | 1931 Horseshoe Kidney | 1932 Renal Absence | 1939 Ureteric Bud Agenesis | 1943 Renal Position

Reference

Ishiyama H, Ishikawa A, Kitazawa H, Fujii S, Matsubayashi J, Yamada S & Takakuwa T. (2018). Branching morphogenesis of the urinary collecting system in the human embryonic metanephros. PLoS ONE , 13, e0203623. PMID: 30192900 DOI.

Copyright

© 2018 Ishiyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fig. 1. https://doi.org/10.1371/journal.pone.0203623.g001 Original figure resized, PMID added and converted to jpg format.



Cite this page: Hill, M.A. (2024, April 26) Embryology Human embryonic renal branching 1.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_embryonic_renal_branching_1.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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