Developmental Signals - Tbx: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[File:Mouse_Tbx5.jpg|thumb|Mouse forelimb Tbx5 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]] | [[File:Mouse_Tbx5.jpg|thumb|Mouse forelimb Tbx5 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]] | ||
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* '''Tbx1 regulates oral epithelial adhesion and palatal development'''<ref name=PMID22371266><pubmed>22371266</pubmed></ref> "Cleft palate, the most frequent congenital craniofacial birth defect, is a multifactorial condition induced by the interaction of genetic and environmental factors. In addition to complete cleft palate, a large number of human cases involve soft palate cleft and submucosal cleft palate. ...These findings suggest that Tbx1 regulates the balance between proliferation and differentiation of keratinocytes and is essential for palatal fusion and oral mucosal differentiation. The impaired adhesion separation of the oral epithelium together with compromised palatal mesenchymal growth is an underlying cause for various forms of cleft palate phenotypes in Tbx1(-/-) mice. Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis." | * '''Tbx1 regulates oral epithelial adhesion and palatal development'''<ref name=PMID22371266><pubmed>22371266</pubmed></ref> "Cleft palate, the most frequent congenital craniofacial birth defect, is a multifactorial condition induced by the interaction of genetic and environmental factors. In addition to complete cleft palate, a large number of human cases involve soft palate cleft and submucosal cleft palate. ...These findings suggest that Tbx1 regulates the balance between proliferation and differentiation of keratinocytes and is essential for palatal fusion and oral mucosal differentiation. The impaired adhesion separation of the oral epithelium together with compromised palatal mesenchymal growth is an underlying cause for various forms of cleft palate phenotypes in Tbx1(-/-) mice. Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis." | ||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Tbx+Embryology ''Tbx Embryology''] | |||
<pubmed limit=5>Tbx Embryology</pubmed> | |||
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==Limb Development== | ==Limb Development== | ||
[[File:Mouse-_forelimb-bud-Tbx3-Tbx2.jpg|600px]] | [[File:Mouse-_forelimb-bud-Tbx3-Tbx2.jpg|600px]] | ||
Mouse forelimb bud Tbx3 and Tbx2 expression<ref name=PMID20386744><pubmed>20386744</pubmed>| [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000901 PLoS Genet.]</ref> | Mouse forelimb bud Tbx3 and Tbx2 expression<ref name=PMID20386744><pubmed>20386744</pubmed>| [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000901 PLoS Genet.]</ref> | ||
Revision as of 14:25, 13 February 2014
Embryology - 28 Apr 2024 Expand to Translate |
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Introduction
Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.
Researchers have identified at least 17 genes in the T-box gene family. Mutations in these genes lead to disorders that involve the abnormal development of tissues in which a particular T-box gene is active (expressed). Many genetic disorders caused by T-box gene mutations are characterized by heart problems and/or skeletal abnormalities of the hands and arms.
(text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Tbx Embryology <pubmed limit=5>Tbx Embryology</pubmed> |
Limb Development
Mouse forelimb bud Tbx3 and Tbx2 expression[3]
- Links: Limb Development
Respiratory Development
Mouse respiratory Tbx4 and Tbx5 model[4]
(Text from figure legend) |
References
- ↑ 1.0 1.1 <pubmed>22174793</pubmed>| PMC3235105 | PLoS One.
- ↑ <pubmed>22371266</pubmed>
- ↑ <pubmed>20386744</pubmed>| PLoS Genet.
- ↑ <pubmed>22876201</pubmed>| PLoS Genet.
Search Bookshelf Tbx
Reviews
<pubmed>17506689</pubmed> <pubmed>10197584</pubmed>
Search Pubmed
Search Pubmed Now: Tbx
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External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- OMIM - http://omim.org/entry/602054
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Cite this page: Hill, M.A. (2024, April 28) Embryology Developmental Signals - Tbx. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Tbx
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G