Developmental Signals - Tbx: Difference between revisions

Revision as of 14:40, 13 February 2013

Introduction

Draft Page.

Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.

Researchers have identified at least 17 genes in the T-box gene family. Mutations in these genes lead to disorders that involve the abnormal development of tissues in which a particular T-box gene is active (expressed). Many genetic disorders caused by T-box gene mutations are characterized by heart problems and/or skeletal abnormalities of the hands and arms.

(text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

^[1]

References

↑ <pubmed></pubmed>

Search Bookshelf Pax

Reviews

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Search Pubmed Now: Tbx

http://www.ncbi.nlm.nih.gov/omim

External Links

OMIM - Pax6

Glossary Links

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Cite this page: Hill, M.A. (2024, April 28) Embryology Developmental Signals - Tbx. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Tbx

What Links Here?

[1] <pubmed></pubmed>

[1]

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 ==Introduction==
+::''Draft Page.''
 Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.
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 (text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)
+{{Factor Links}}
+==Some Recent Findings==
+{|
+|-bgcolor="F5FAFF"
+|
+* <ref><pubmed></pubmed></ref>
+|}
+==References==
+<references/>
+'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Pax Pax]
+===Reviews===
+<pubmed>17506689</pubmed>
+<pubmed>10197584</pubmed>
+===Search Pubmed===
+'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Tbx Tbx]
+http://www.ncbi.nlm.nih.gov/omim
+==External Links==
+* OMIM - [http://www.ncbi.nlm.nih.gov/omim/607108 Pax6]
+{{Glossary}}
+{{Footer}}
+[[Category:Tbx]] [[Category:Molecular]] [[Category:Pattern]]
+[[Category:Neural]] [[Category:Limb]]