Introduction
Human testis NANOG expression
[1]
NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells.
Some Recent Findings
- Multiple phases in regulation of Nanog expression during pre-implantation development[2] "Nanog is a key transcriptional factor for the maintenance of pluripotency of ES cells, iPS cells or cells in early mammalian embryos. The expression of Nanog is mainly localized to the epiblast in the late blastocyst. The Nanog gene expression pattern varies between embryos and between blastomeres during blastocyst formation. In this report, we traced the changes of Nanog expression in each cell in developing preimplantation mouse embryos through time-lapse observation of Nanog-GFP transgenic mouse embryos. The expression pattern of Nanog was classified into four phases depending on the developmental stage. Nanog expression started at very low levels during cleavage stages. It increased stochastically during the morula stage, but its expression level had no clear correlation with future cell fates. After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages. These results indicate that there are multiple phases in the transcriptional regulation of Nanog during blastocyst formation." Morula | Blastocyst | Mouse Development
- Phosphorylation stabilizes Nanog by promoting its interaction with Pin1[3]"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms."
- Nanog variability and pluripotency regulation of embryonic stem cells[4]"The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression of Nanog and that individual ES cells reversibly change their Nanog expression level."
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More recent papers
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Search term: Nanog
<pubmed limit=5>Nanog</pubmed>
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Classification
Functions
Required for embryonic stem cell self-renewal.
Spermatogenesis
The cartoons below show nanog expression in mouse and dog during spermatogenesis.[5]
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Each column represents the combination of different cell types that are present in seminiferous tubules at that specific stage.
Cell types that express NANOG are outlined in red and cell types that do not express NANOG have black and grey symbols.
Legend
- 1–16 = steps in spermiogenesis
- In = intermediate spermatogonia
- B = type B spermatogonia
- Pl = pre-leptotene stage
- L = leptotene stage
- Z = zygotene stage
- P = pachytene stage
- D = diplotene stage
- 2nd = generation of secondary spermatocytes
- Roman figures = stage of the epithelial cycle
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Signaling Pathway
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Two-level process for the induction of stem cell differentiation[4]
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References
- ↑ <pubmed>20539761</pubmed>
- ↑ <pubmed>26660234</pubmed>
- ↑ <pubmed>20622153</pubmed>
- ↑ 4.0 4.1 4.2 <pubmed>20574542</pubmed>| PLoS One
- ↑ <pubmed>20539761</pubmed>| PLoS One.
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Cite this page: Hill, M.A. (2024, April 26) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
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