Stem Cells - Adult
The term "stem cells" is now used widely to cover many different cells derived from both embryo and adult tissues.
A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) and more recently NIH has established a Stem Cell information page.
This page also currently has some information on Somatic Cell Nuclear Transfer (SCNT), see also Fertilization.
|Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced pluripotent stem cell | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Organoids | Adult Human Cell Types | Category:Stem Cell|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
Induced Pluripotent Stem Cell
(iPS cell) A reprogrammed adult stem cell to form an embryonic stem cell, from which tissues or whole animals can develop. Can be generated by the expression of just four specific transcription factors.
- Links: Induced Stem Cells
Bone Marrow Stem Cell
Bone marrow stromal stem cells
Skin Stem Cell
De Rosa L & De Luca M. (2012). Cell biology: Dormant and restless skin stem cells. Nature , 489, 215-7. PMID: 22972293 DOI. Mascré G, Dekoninck S, Drogat B, Youssef KK, Broheé S, Sotiropoulou PA, Simons BD & Blanpain C. (2012). Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature , 489, 257-62. PMID: 22940863 DOI.
Hair Follicle Stem Cell
Dental Pulp Stem Cell (DPSC)
Dental pulp stem/stromal cell (DPSC) are similar to bone marrow derived mesenchymal stem/stromal cells (hBMSCs) in the expression pattern of cell surface markers and their pluripotent differentiation capability.
Huang AH, Snyder BR, Cheng PH & Chan AW. (2008). Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice. Stem Cells , 26, 2654-63. PMID: 18687995 DOI.
Munoz JR, Stoutenger BR, Robinson AP, Spees JL & Prockop DJ. (2005). Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc. Natl. Acad. Sci. U.S.A. , 102, 18171-6. PMID: 16330757 DOI.
Spermatogonial Stem Cell
Neural Stem Cell
In the adult brain, the subependymal zone (SEZ) (a thin layer of cells lining the lateral wall of the lateral brain ventricles) is a source of neural stem cells (NSCs). Hes1, a basic helix-loop-helix (bHLH) transcription factor, appears to be a key regulator of neural stem cell development. Hes1 has a dual transcriptional role, able to act as a repressor or a transcriptional activator for different genes.
- Links: OMIM - Hes1
Somatic Cell Nuclear Transfer
In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor.
SCNT using a range of different cell types has been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review)
- Sueda R, Imayoshi I, Harima Y & Kageyama R. (2019). High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain. Genes Dev. , , . PMID: 30862661 DOI.
- Reilein A, Melamed D, Tavaré S & Kalderon D. (2018). Division-independent differentiation mandates proliferative competition among stem cells. Proc. Natl. Acad. Sci. U.S.A. , , . PMID: 29555768 DOI.
- Rocheteau P, Gayraud-Morel B, Siegl-Cachedenier I, Blasco MA & Tajbakhsh S. (2012). A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division. Cell , 148, 112-25. PMID: 22265406 DOI.
- Galli C, Lagutina I, Perota A, Colleoni S, Duchi R, Lucchini F & Lazzari G. (2012). Somatic cell nuclear transfer and transgenesis in large animals: current and future insights. Reprod. Domest. Anim. , 47 Suppl 3, 2-11. PMID: 22681293 DOI.
- Campbell KH, McWhir J, Ritchie WA & Wilmut I. (1996). Sheep cloned by nuclear transfer from a cultured cell line. Nature , 380, 64-6. PMID: 8598906 DOI.
- Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de León FA & Robl JM. (1998). Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science , 280, 1256-8. PMID: 9596577
- Wakayama T, Perry AC, Zuccotti M, Johnson KR & Yanagimachi R. (1998). Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature , 394, 369-74. PMID: 9690471 DOI.
- Baguisi A, Behboodi E, Melican DT, Pollock JS, Destrempes MM, Cammuso C, Williams JL, Nims SD, Porter CA, Midura P, Palacios MJ, Ayres SL, Denniston RS, Hayes ML, Ziomek CA, Meade HM, Godke RA, Gavin WG, Overström EW & Echelard Y. (1999). Production of goats by somatic cell nuclear transfer. Nat. Biotechnol. , 17, 456-61. PMID: 10331804 DOI.
- Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, Colman A & Campbell KH. (2000). Cloned pigs produced by nuclear transfer from adult somatic cells. Nature , 407, 86-90. PMID: 10993078 DOI.
Moraleda JM, Blanquer M, Bleda P, Iniesta P, Ruiz F, Bonilla S, Cabanes C, Tabares L & Martinez S. (2006). Adult stem cell therapy: dream or reality?. Transpl. Immunol. , 17, 74-7. PMID: 17157222 DOI.
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Cite this page: Hill, M.A. (2023, December 2) Embryology Stem Cells - Adult. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Stem_Cells_-_Adult
- © Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G