Carnegie stage 10

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Introduction

Stage10 bf1c.jpg

Facts

Week 4, 22 - 23 days, 2 - 3.5 mm, Somite number 4 - 12

Gestational Age GA - week 6

Features

  • Somite Number 4 - 12, rostral neuropore, neural folds in region of developing brain, neural tube, somites, caudal neuropore, neural fold fuses, remnant of amniotic sac

Summary

  • Ectoderm: Neural fold deeepens, edges approach midline, neural fold fuses, neural plate folds ventrally in brain region
  • Mesoderm: Somitogenesis, continued segmentation of paraxial mesoderm (4 - 12 somite pairs)

See also Events

Identify

The rostral neuropore, neural folds in region of developing brain, neural tube, somites (note the different number formed), caudal neuropore, neural fold fuses, cut edge of amniotic sac.


Links: Week 4 | Gastrulation | Lecture | Practical | Carnegie stage 10 image gallery | Category:Carnegie Stage 10 | Stage 11
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Stage10 bf1c.jpg Stage10 bf2c.jpg Stage10 bf3.jpg Heart Tube Segments.jpg

Scanning EM

Stage10 sem1.jpg

Stage10 sem2.jpg

Stage10 sem3.jpg Stage10 sem4.jpg

Stage10 sem5.jpg

Stage10 sem6.jpg

Stage10 sem7.jpg

Stage10 sem8.jpg

Stage10 sem9.jpg

Stage10 sem10.jpg

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development

Kyoto Collection

Facts: Week 4, 22 - 23 days, 2 - 3.5 mm, Somite Number 4 - 12

View: This is a dorsal view of the human embryo, the amniotic membrane has been removed. Top embryo is an early stage 10, bottom is late stage 10.

Early Late
Stage10 bf4.jpg Stage10 bf5.jpg Stage10 bf6.jpg

Stage10 bf10.jpg

Stage 10 Embryo (12202) - transverse section  

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Stage10 bf7.jpg Stage10 bf8.jpg Stage10 bf9.jpg Stage10 bf10.jpg

Carnegie Collection - Stage 10 
Serial No. Pairs of somites Size (mm) Grade Fixative Embedding Medium Thinness (µm) Stain Year Notes
391 8 E, 2 Ch., 14 Good Formol P 10 Al. coch. 1907 Monograph by Dandy (1910)[1]
1201 7 E,2 Ch.. 144 Good Formol P 8 H. & or. G. 1915 Univ. Chicago No. H 87
2795 4-5 E,2 Poor Alc. P 6 Al coch,or.G. 1919
3707 12 E, 1 5 Good Formol P 12.5 I. H. 1921 Univ. Calif. No. H 197
3709 4 E. 1.4 Ch.. 14.8 Poor Formol P 10 Erythrosin 1921 Univ. Chicago No H 279
3710 12 E., 3.6 Ch., 19.0 Good Formol C-P 10 H. & or. G. 1921 Univ. Chicago No. H 392
4216 8 E, 2 Ch, 9.8 Good Formol P 15 ? 1923 Monograph by Payne (1925)[2]
5074 10 E., 3.3 Ch., 10.8 Exc. Bouin P 10 Al. coch. 1925 Univ. Rochester No. H 10. Monograph by Corner (1929)[3]
6330 7 E, 2.83 Good P 5 Ehr. H. 1931 Univ. Chicago No. H 1404
6740 12 E., 2.2 Good p C-P 8 ? 1933 Litzenberg embryo. Studied by Boyden (1940)
7251 8 E., 1.27 Good Formol C-P 10 (Stain - Haematoxylin Eosin) 1941 "Singapore embryo." Univ. Cambridge No. H 98.
Studied by Wilson (1914)[4]
8244 6 E., 1.55 Ch, 8,5 Good Alc. C-P 8 (Stain - Haematoxylin Eosin) phlox. 1944
9870 12 Ch, ca. 8 Good Zenker P 5 Various, chiefly carmine 1952 Univ. Chicago. No. H 637. Dicephaly
Abbreviations
  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  •  ? - unknown or not determined.
  • All Carnegie stage 10 embryos are cut in Transverse plane.
iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Events

For a detailed description of the stage 10 human embryos see the papers published 1910[1], 1929, [5], 1939 [6], review by Heuser in 1957[7] and in chapter by O'Rahilly and Müller in 1987.[8]

  • Hearing - 10 somites first indication of otic placode invagination[5] 12 somites cells migrate from the otic disc.[9]
  • Vision - optic primordia appear.[10]


References

  1. 1.0 1.1 Dandy WE. A human embryo with seven pairs of somites measuring about 2 mm in length. (1910) Amer. J Anat. 10: 85-109.
  2. Payne, F. 1925. General description of a 7-somite human embryo. Carnegie Instn. Wash. Publ. 361, Contrib. Embryol., 16,115-124.
  3. Corner GW. A well-preserved human embryo of 10 somites. (1929) Contrib. Embryol., Carnegie Inst. Wash. Publ. 394, 20:81-102.
  4. Wilson JT. Observations upon young human embryos. (1914) J Anat Physiol., 48(3): 315-51 PMID 17233002 PMC1288949
  5. 5.0 5.1 Corner GW. A well-preserved human embryo of 10 somites. (1929) Carnegie Instn. Wash. Publ. 394, Contrib. Embryol., 20: 81-102.
  6. Baxter JS. and Boyd JD. Observations on the neural crest of a ten-somite human embryo (1939) J Anat. 73: 318–326. PMID 17104759
  7. Heuser CH. and Corner GW. Developmental horizons in human embryos. Description of age group X, 4 to 12 somites. (1957) Carnegie Instn Wash Publ 611, Contrib. Embryol., 36: 29-39.
  8. O'Rahilly R. and Müller F. Developmental Stages in Human Embryos. Contrib. Embryol., Carnegie Inst. Wash. 637 (1987).
  9. Bartelmez GW. and Evans HM. Development of the human embryo during the period of somite formation, including embryos with 2 to 16 pairs of somites. (1926) Contrib. Embryol., Carnegie Inst. Wash. Publ. 362, 17: 1-67.
  10. <pubmed>7364662</pubmed>

Additional Images

Historic

Dandy WE. A human embryo with seven pairs of somites measuring about 2 mm in length. (1910) Amer. J Anat. 10: 85-109.

Baxter JS. and Boyd JD. Observations on the neural crest of a ten-somite human embryo (1939) J Anat. 73: 318–326. PMID 17104759

Heuser CH. and Corner GW. Developmental horizons in human embryos. Description of age group X, 4 to 12 somites. (1957) Carnegie Instn Wash Publ 611, Contrib. Embryol., 36: 29-39.


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline



Cite this page: Hill, M.A. (2019, November 20) Embryology Carnegie stage 10. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_10

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G