Abnormal Development - Parvovirus

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Notice - Mark Hill
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Introduction

Human parvovirus B19 (Latin, parvo = poor), infection is also called "fifth disease" and occurs mainly in children. Pets (dogs and cats) have their own animal parvoviruses that do not infect humans.

Parvovirus B19 (B19V) is the only member of the Parvoviridae family known to cause disease in humans and is a single-strand 5,594 nucleotide DNA Class II virus (More? Genome). The virions have a diameter of 22-25 nm and are transmitted by respiratory secretions between humans and can also cross the placenta. Virus replication requires help from either host cells or other viruses.

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Some Recent Findings

Fifth Disease

The term "fifth disease" arose due to this being the fifth in a group of once-common childhood diseases (the other four are measles, rubella, scarlet fever and Dukes' disease) that all have similar rashes.


B19

Professor Yvonne Cossart (University of Sydney, Bosch Professor of Infectious Diseases)

Yvonne Cossart coined the nomenclature "B19", from the well on a microtitre plate where the virus antigen was first discovered in blood (Cossart etal., 1975). Microtitre plates are generally organised by rows (alphabetically) and columns (numerically).

"A parvovirus-like antigen has been found in sera of nine healthy blood-donors and two patients. Its pathogenicity is unknown, but 30% of adults possess specific antibody. The new agent can be confused with hepatitis-B antigen both morphologically and serologically." [1]

References

  1. ↑ <pubmed>46024</pubmed>

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Cite this page: Hill, M.A. (2024, May 5) Embryology Abnormal Development - Parvovirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Parvovirus

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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