Abnormal Development - Herbal Drugs: Difference between revisions
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* '''Evaluation of in Vitro Embryotoxicity Tests for Chinese Herbal Medicines'''{{#pmid:31228572|PMID31228572}} "Chinese herbal medicines (CHMs) have been widely used during pregnancy, but feto-embryo safety tests are lacking. Here we evaluated in vitro embryotoxicity tests (IVTs) as alternative methods in assessing developmental toxicity of CHMs. Ten CHMs were selected and classified as strongly, weakly and non-embryotoxic. Three well validated IVTs and prediction models (PMs), including embryonic stem cell test (EST), micromass (MM) and whole embryo culture (WEC), were compared. All strongly embryotoxic CHMs were predicted by MM and WEC PM2. While all weakly embryotoxic CHMs were predicted by MM and WEC PM1. All non-embryotoxic CHMs were classified by EST, MM, but over-classified as weakly embryotoxic by WEC PM1. Overall predictivity, precision and accuracy of WEC determined by PM2 were better than EST and MM tests. Compared with validated chemicals, performance of IVTs for CHMs was comparable. So IVTs are adequate to identify and exclude embryotoxic potential of CHMs in this training set." | |||
* '''Evaluation of | * '''Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish ( Danio rerio)'''{{#pmid:30949217|PMID30949217}} "Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. ... Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development." | ||
* '''Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca (AYA) in rats'''{{#pmid:29522798|PMID29522798}} "Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. ...This study suggested that AYA is developmentally toxic and that its daily use by pregnant women may pose risks for the conceptus." | * '''Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca (AYA) in rats'''{{#pmid:29522798|PMID29522798}} "Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. ...This study suggested that AYA is developmentally toxic and that its daily use by pregnant women may pose risks for the conceptus." | ||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Herbal+Drugs+Teratogenicity ''Herbal Drugs Teratogenicity''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Herbal+Drugs+Teratogen ''Herbal Drugs Teratogen''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Black+Cohosh+Teratogen ''Black Cohosh Teratogen''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Herbal+Drugs+Teratogenicity ''Herbal Drugs Teratogenicity''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Herbal+Drugs+Teratogen ''Herbal Drugs Teratogen''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Black+Cohosh+Teratogen ''Black Cohosh Teratogen''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Cat’s+Claw+Teratogen ''Cat’s Claw Teratogen''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Ginkgo+Teratogen ''Ginkgo Teratogen''] | ||
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* '''Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report'''{{#pmid:21453474|PMID21453474}} "We describe the pediatric environmental history of a three-year-old Caucasian girl with an autism spectrum disorder. We utilized her pediatric environmental history to evaluate constitutional, genetic, and environmental factors pertinent to manifestation of neurodevelopment disorders. Both parents reported prenatal exposure to several risk factors of interest. A year prior to conception the mother began a weight loss diet and ingested 1200mg/day of 'horsetail' (Equisetum arvense) herbal remedies containing thiaminase, an enzyme that with long-term use can lead to vitamin deficiency. The mother reported a significant weight loss during the pregnancy and a deficiency of B-complex vitamins. Thiamine (vitamin B1) deficiency could have been potentiated by the horsetail's thiaminase activity and ethanol exposure during pregnancy. No other risk factors were identified." | |||
* '''Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats'''{{#pmid:20437472|PMID20437472}} "Ginkgo biloba extract (GBE) is an herbal medicine used for treating neurodegenerative diseases, cerebrovascular insufficiency, peripheral arterial occlusive disease, and also vestibular disturbance. ...The GBE treatment in pregnant Wistar rats, during the tubal transit and implantation period, caused no toxic effect on the maternal organism and did not induce embryonic death, growth retardation, and/or fetal malformations." | * '''Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats'''{{#pmid:20437472|PMID20437472}} "Ginkgo biloba extract (GBE) is an herbal medicine used for treating neurodegenerative diseases, cerebrovascular insufficiency, peripheral arterial occlusive disease, and also vestibular disturbance. ...The GBE treatment in pregnant Wistar rats, during the tubal transit and implantation period, caused no toxic effect on the maternal organism and did not induce embryonic death, growth retardation, and/or fetal malformations." | ||
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| Cat’s Claw (''Uncaria tomentosa'', ''Uncaria guianensis'') should be avoided because of its past use for preventing and aborting pregnancy. | | Cat’s Claw (''Uncaria tomentosa'', ''Uncaria guianensis'') should be avoided because of its past use for both preventing and aborting pregnancy. | ||
Search PubMed [http://www.ncbi.nlm.nih.gov/pubmed/?term=Cat’s+Claw+Teratogen ''Cat’s Claw Teratogen''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Uncaria+tomentosa+Teratogen ''Uncaria tomentosa Teratogen''] | |||
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==Chasteberry== | ==Chasteberry== |
Revision as of 14:31, 29 June 2020
Embryology - 10 Jun 2024 Expand to Translate |
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العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose. |
Introduction
This page introduces the possible effects of maternal use of herbal drugs (therapeutic chemicals/agents) on development. In some cases these drugs are "prescribed" to treat pre-existing or pregnancy related maternal medical conditions. In all cases, a discussion with a medical practioner should be had prior to any reproductive decision.
The following herbal drugs have been used for a number of different maternal conditions: Ginkgo Biloba, Kava (Piper methysticum), St. John's wort (Hypericum perforatum), Tian Ma (Gastrodia elata), Valerian (Valeriana officinalis). In some cases very little is known about the potential teratogenic effects of these drugs. Furthermore, care should be made when comparing evaluation of drugs in different species.[1]
The National Center Complementary and Alternative Medicine (USA) provides excellent summary information sheets on many of the commonly used herbal treatments, though many of these information sheets do not include information about herbal drug use during pregnancy. This current page gives some examples of herbs which may impact on development, for further information see NIH - Herbs at a Glance PDF.
Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose. |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Herbal Drugs Teratogenicity | Herbal Drugs Teratogen | Black Cohosh Teratogen | Cat’s Claw Teratogen | Ginkgo Teratogen |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Ayahuasca
Ayahuasca (AYA, iowaska, yagé) is a psychoactive substance made by South American natives from of Banisteriopsis caapi vine and other ingredients. A recent study in rats[4] at a range of ayahuasca concentrations, corresponding from 1x to 8x the human dosage, demonstrated a number of fetotoxic effects:
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Black Cohosh
Black cohosh (Actaea racemosa, Cimicifuga racemosa, black snakeroot, macrotys, bugbane, bugwort, rattleroot, rattleweed) is a member of the buttercup family and is native to North America. It is not clear if black cohosh is safe for women with a liver disorder, hormone-sensitive conditions, or for pregnant women or nursing mothers.
Black cohosh should not be confused with blue cohosh (Caulophyllum thalictroides).
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Cat’s Claw
Cat’s Claw (Uncaria tomentosa, Uncaria guianensis) should be avoided because of its past use for both preventing and aborting pregnancy.
Search PubMed Cat’s Claw Teratogen | Uncaria tomentosa Teratogen |
Chasteberry
Chasteberry (Vitex agnus-castus, chaste-tree berry, vitex, monk’s pepper) is the fruit of the chaste tree. This herb may affect certain hormone levels, women who are pregnant or taking birth control pills or who have a hormone-sensitive condition (such as breast cancer) should not use chasteberry.
Search PubMed: Chasteberry Teratogen | Chasteberry | Vitex agnus-castus
Ephedra
Ephedra (Ephedra sinica) is an evergreen shrub-like plant, the principal active ingredient ephedrine can powerfully stimulate the nervous system and heart. In 2004, the FDA banned the U.S. sale of dietary supplements containing ephedra.
Specific ingredients include alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds.[7] Search PubMed: Ephedra Teratogen | Ephedra |
Fenugreek
Fenugreek (Trigonella foenum-graecum) is a legume plant who's seeds are commonly as a food spice. It was used historically for inducing childbirth.
Search PubMed: Fenugreek Teratogen | Fenugreek
Feverfew
Ginkgo Biloba
Ginkgo leaf extract has been used to treat a variety of ailments and conditions, including asthma, bronchitis, fatigue, and tinnitus (ringing or roaring sounds in the ears).
Extracts are usually taken from the ginkgo leaf and are used to make tablets, capsules, or teas. Occasionally, ginkgo extracts are used in skin products. Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats[6] "Ginkgo biloba extract (GBE) is an herbal medicine used for treating neurodegenerative diseases, cerebrovascular insufficiency, peripheral arterial occlusive disease, and also vestibular disturbance. ...The GBE treatment in pregnant Wistar rats, during the tubal transit and implantation period, caused no toxic effect on the maternal organism and did not induce embryonic death, growth retardation, and/or fetal malformations."
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Goldenseal
Goldenseal (Hydrastis canadensis, orange-root, yellow-root) is a perennial herb in the buttercup family, it contains the chemical berberine that can cause or worsen jaundice in newborns and may lead to a life-threatening problem called kernicterus.
Search PubMed: Goldenseal Teratogen |
Horsetail
Field Horsetail or Common Horsetail (Equisetum arvense, rhizomatous stem formation) is a bushy perennial herb native to the northern hemisphere.
The herb contains containing thiaminase, an enzyme that with long-term use can lead to vitamin deficiency. Has been used in weight loss diets, and a case report has identified that combined with alcohol linked to autism spectrum disorder.[5]
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Licorice Root
Licorice (Glycyrrhiza glabra, Glycyrrhiza uralensis, gan zao (Chinese licorice)) contains a compound called glycyrrhizin (or glycyrrhizic acid) and consuming large amounts of licorice as food may alter cortisol and related steroid drug levels, as well as increase the risk of preterm labor.
Red Clover
Red clover (Trifolium pratense) is a legume and contains phytoestrogens, compounds that are similar to the female hormone estrogen. |
St. John's Wort
Yohimbe
Yohimbe (Pausinystalia yohimbe ) is derived from the bark of a tall evergreen tree native to western Africa. Women who are pregnant or breastfeeding should not take yohimbe.
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References
- ↑ Nau H. (1986). Species differences in pharmacokinetics and drug teratogenesis. Environ. Health Perspect. , 70, 113-29. PMID: 3104022
- ↑ Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H & Wang CC. (2019). Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod. Toxicol. , 89, 45-53. PMID: 31228572 DOI.
- ↑ Alafiatayo AA, Lai KS, Syahida A, Mahmood M & Shaharuddin NA. (2019). Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio). Evid Based Complement Alternat Med , 2019, 3807207. PMID: 30949217 DOI.
- ↑ 4.0 4.1 da Motta LG, de Morais JA, Tavares ACAM, Vianna LMS, Mortari MR, Amorim RFB, Carvalho RR, Paumgartten FJR, Pic-Taylor A & Caldas ED. (2018). Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca in rats. Reprod. Toxicol. , , . PMID: 29522798 DOI.
- ↑ 5.0 5.1 Ortega García JA, Angulo MG, Sobrino-Najul EJ, Soldin OP, Mira AP, Martínez-Salcedo E & Claudio L. (2011). Prenatal exposure of a girl with autism spectrum disorder to 'horsetail' (Equisetum arvense) herbal remedy and alcohol: a case report. J Med Case Rep , 5, 129. PMID: 21453474 DOI.
- ↑ 6.0 6.1 Fernandes ES, Pinto RM, de Paula Reis JE, de Oliveira Guerra M & Peters VM. (2010). Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats. Birth Defects Res. B Dev. Reprod. Toxicol. , 89, 133-8. PMID: 20437472 DOI.
- ↑ Miao SM, Zhang Q, Bi XB, Cui JL & Wang ML. (2020). A review of the phytochemistry and pharmacological activities of Ephedra herb. Chin J Nat Med , 18, 321-344. PMID: 32451091 DOI.
Books
- Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Benzie IFF, Wachtel-Galor S, editors. Boca Raton (FL): CRC Press; 2011. Bookshelf
Reviews
- Saunders EJ, Saunders JA. Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin. Health Care Women Int. 1990;11(4):423-32.
Articles
- McBride WG. Prescription drugs in the first trimester and congenital malformations. Aust N Z J Obstet Gynaecol. 1992 Nov;32(4):386.
Search Pubmed
June 2010 "herbal drugs in pregnancy" All (395) Review (50) Free Full Text (30)
Search Pubmed: herbal drugs in pregnancy | herbal drug teratogen
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- National Center Complementary and Alternative Medicine (USA)
- NIH - Herbs at a Glance PDF
- United Nations International Drug Control Programme
- Australian Drug Foundation (ADF)
- Centre for Education and Information on Drugs and Alcohol (CEIDA) (Australia)
- Child Health and Safety (Australia)
- NIDA (USA)- Consequences of Prenatal Drug Exposure
- Australian Medicines Handbook (no electronic version yet)
- Australian Congenital Anomalies Monitoring System (ACAMS)
- Australian Institute of Health and Welfare (AIHW)
Terms
Drug Terms | ||
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Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 10) Embryology Abnormal Development - Herbal Drugs. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Herbal_Drugs
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G