Neural - Vascular Development: Difference between revisions
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* '''Formation of the circle of Willis during human embryonic development'''<ref name=PMID27037515><pubmed>27037515</pubmed></ref> "The circle of Willis (CW) is a circulatory anastomosis that supplies blood to the brain and adjacent structures. We examined the timing of formation of CW in 20 Japanese human embryo samples by using 3-dimensional reconstruction of serial histological sections. The CW was closed in 1 (n = 6), 2 (n = 8), 2 (n = 3) and 2 (n = 3) samples at Carnegie stages 20, 21, 22, and 23, respectively. The CW was unclosed in 13 samples (unclosed at ACOM alone, 6 samples; ACOM and bilateral P1, 4; left PCOM and right P1, 1; right PCOM and right P1, 1; ACOM and left PCOM, 1). It was difficult to predict whether the circle would close during further development, as such variations frequently exist in adults." | |||
* '''Foxc1 is required for early stage telencephalic vascular development'''<ref name=PMID25733312><pubmed>25733312</pubmed></ref> "The brain vascular system arises from the perineural vascular plexus (PNVP) which sprouts radially into the neuroepithelium and subsequently branches off laterally to form a secondary plexus in the subventricular zone (SVZ), the subventricular vascular plexus (SVP). The process of SVP formation remains to be fully elucidated. We investigated the role of Foxc1 in early stage vascular formation in the ventral telencephalon. Results: The Foxc1 loss of function mutant mouse, Foxc1ch/ch , showed enlarged telencephalon and hemorrhaging in the ventral telencephalon by E11.0. The mutant demonstrated blood vessel dilation and aggregation of endothelial cells in the SVZ after the invasion of endothelial cells through the radial path, which lead to failure of SVP formation. During this early stage of vascular development, Foxc1 was expressed in endothelial cells and pericytes, as well as in cranial mesenchyme surrounding the neural tube." | * '''Foxc1 is required for early stage telencephalic vascular development'''<ref name=PMID25733312><pubmed>25733312</pubmed></ref> "The brain vascular system arises from the perineural vascular plexus (PNVP) which sprouts radially into the neuroepithelium and subsequently branches off laterally to form a secondary plexus in the subventricular zone (SVZ), the subventricular vascular plexus (SVP). The process of SVP formation remains to be fully elucidated. We investigated the role of Foxc1 in early stage vascular formation in the ventral telencephalon. Results: The Foxc1 loss of function mutant mouse, Foxc1ch/ch , showed enlarged telencephalon and hemorrhaging in the ventral telencephalon by E11.0. The mutant demonstrated blood vessel dilation and aggregation of endothelial cells in the SVZ after the invasion of endothelial cells through the radial path, which lead to failure of SVP formation. During this early stage of vascular development, Foxc1 was expressed in endothelial cells and pericytes, as well as in cranial mesenchyme surrounding the neural tube." | ||
* '''Review - The human brain intracerebral microvascular system: development and structure.'''<ref name=PMID22993505><pubmed>22993505</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440694 PMC3440694] | [http://journal.frontiersin.org/article/10.3389/fnana.2012.00038/abstract Front Neuroanat.]</ref> "The capillary from the meningeal inner pial lamella play a crucial role in the development and structural organization of the cerebral cortex extrinsic and intrinsic microvascular compartments. Only pial capillaries are capable of perforating through the cortex external glial limiting membrane (EGLM) to enter into the nervous tissue, although incapable of perforating the membrane to exit the brain. Circulatory dynamics and functional demands determine which capillaries become arterial and which capillaries become venous." | * '''Review - The human brain intracerebral microvascular system: development and structure.'''<ref name=PMID22993505><pubmed>22993505</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440694 PMC3440694] | [http://journal.frontiersin.org/article/10.3389/fnana.2012.00038/abstract Front Neuroanat.]</ref> "The capillary from the meningeal inner pial lamella play a crucial role in the development and structural organization of the cerebral cortex extrinsic and intrinsic microvascular compartments. Only pial capillaries are capable of perforating through the cortex external glial limiting membrane (EGLM) to enter into the nervous tissue, although incapable of perforating the membrane to exit the brain. Circulatory dynamics and functional demands determine which capillaries become arterial and which capillaries become venous." |
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Introduction
Draft Page
See the historic articles on human vascular development by:
- Mall FP. On the Development of the Blood-Vessels of the Brain in the Human Embryo. (1905) Amer. J. of Anat. 4; 1–18.
- Streeter GL. The Developmental Alterations in the Vascular System of the Brain of the Human Embryo (1921)
Some Recent Findings
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More recent papers |
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More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Neural Vascular System Development <pubmed limit=5>Neural Vascular System Development</pubmed> |
Cerebral Blood Supply Development
Embryonic stage
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(above text modified from reference[4])
Cerebral Veins
Figures from the 1905 study by Mall.[5]
Molecular
Foxc1
- required for early stage telencephalic vascular development[2]
References
- ↑ <pubmed>27037515</pubmed>
- ↑ 2.0 2.1 <pubmed>25733312</pubmed>
- ↑ <pubmed>22993505</pubmed>| PMC3440694 | Front Neuroanat.
- ↑ <pubmed>26060802</pubmed>| J Stroke.
- ↑ Mall FP. On the Development of the Blood-Vessels of the Brain in the Human Embryo. (1905) Amer. J. of Anat. 4; 1–18.
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Articles
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Historic
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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers) |
The Developmental Alterations in the Vascular System of the Brain of the Human Embryo (1921)
Gillilan, LA. Significant superficial anastomoses in the arterial blood supply to the human brain. J Comp Neurol. 1959 Jun;112:55-74. PMID 13850118
Gray, Henry. Anatomy of the Human Body Philadelphia: Lea & Febiger, 1918.
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Cite this page: Hill, M.A. (2024, June 15) Embryology Neural - Vascular Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Vascular_Development
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