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2. Dystrophin is a critical protein that is responsible for linking the actin filaments to the sarcolemma, which is a protein that is located in the interior of the plasma membrane of individual muscle fibres<ref><pubmed>11917091</pubmed></ref>. Dystrophin is critical in ensuring the stability of muscle fibres and without it intracellular calcium handling is altered resulting in muscular function being impaired<ref><pubmed>15470384 </pubmed></ref>. | 2. Dystrophin is a critical protein that is responsible for linking the actin filaments to the sarcolemma, which is a protein that is located in the interior of the plasma membrane of individual muscle fibres<ref><pubmed>11917091</pubmed></ref>. Dystrophin is critical in ensuring the stability of muscle fibres and without it intracellular calcium handling is altered resulting in muscular function being impaired<ref><pubmed>15470384 </pubmed></ref>. | ||
3. Other organs that are affected by this disorder are the heart and those responsible for respiration as there is gradual loss of healthy muscular fibres which by cellular repair mechanisms are replaced with inelastic fibrous tissue resulting in less effective contractions resulting in cardiac and respiratory failure<ref><pubmed>4767260</pubmed> . | 3. Other organs that are affected by this disorder are the heart and those responsible for respiration as there is gradual loss of healthy muscular fibres which by cellular repair mechanisms are replaced with inelastic fibrous tissue resulting in less effective contractions resulting in cardiac and respiratory failure<ref><pubmed>4767260</pubmed></ref> . | ||
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Revision as of 20:59, 6 October 2016
Student Information (expand to read) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Individual Assessments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Please leave this template on top of your student page as I will add your assessment items here. Beginning your online work - Working Online in this course
Click here to email Dr Mark Hill | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 1 Assessment - Researching a Topic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
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Lab 2 Assessment - Uploading an Image | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
OK you are now in a group
Initially the topic can be as specific or as broad as you want. Chicken embryo E-cad and P-cad gastrulation[1] References
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Lab 4 Assessment - GIT Quiz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ANAT2341 Quiz Example | Category:Quiz | ANAT2341 Student 2015 Quiz Questions | Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz. An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 5 Assessment - Course Review | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Complete the course review questionnaire and add the fact you have completed to your student page. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 6 Assessment - Cleft Lip and Palate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 7 Assessment - Muscular Dystrophy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 8 Assessment - Quiz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A brief quiz was held in the practical class on urogenital development. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 9 Assessment - Peer Assessment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 10 Assessment - Stem Cells | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
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Lab 11 Assessment - Heart Development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.
<pubmed>26932668</pubmed>Development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 1 Assessment
<pubmed>26446757</pubmed>
In the aforementioned research article, the "Onobrychis Viciifolia" or rather, sanfoin is explored in detail with respect to its ability to self fertilise and therefore be a sustainable and useful plant for its local ecosystem. This is due to its ability to reduce the need of nitrogen fixation by bacteria as a Legume. On top of this, Sanfoin has tannins in it that assist with the break down of proteins and as such, it is beneficial to animals.
This research article utilises naturally directed pollination and artificially directed pollination to compare rates of self fertilisation. Interestingly, the plants of sanfoin that used artificially directed pollination had much higher rates of self fertilisation than the natural counterpart. Whilst there are other results obtained, these are the main results that by implication indicate that we can assist the growth of local plant systems by artifically pollinating sanfoin, which will provide nutrients and reduce the dependence on nitrogen fixation for plants to obtain nitrogen.
Mark Hill 18 August 2016 - You have added the citation correctly and written a good brief summary of the article findings. However, a plant study on "fertilisation" is not really what I was asking, in particular as this is not a Botany course, please try and focus on course content.
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Assessment 4/5 |
Lab 2 Assessment
Mark Hill (talk) 10:17, 19 August 2016 (AEST) you need to use the full file name (.jpeg).
Effect of extracellular Ca2+ depletion on the human zona pellucida-induced intracellular [Ca2+] increase in spermatozoa[1]
Mark Hill 29 August 2016 - All information Reference, Copyright and Student Image template not included with the file and citation not referenced on your page here. I cannot complete the assessment without knowing the original source (reference for this image). Please update so that I can complete the assessment. | Assessment ?? |
Lab 3 Assessment
Mark Hill 29 August 2016 - Quiz Mesoderm and Neural | Assessment 5/5 |
Lab 4 Assessment
Gastrointestinal Tract Developmen
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Lab 5 Assessment
I have completed the prescribed questionnaire during lab.
Lab 6 Assessment
1. A known genetic mutation that is associated with cleft lip is the mutation of the p63 or TP63 which allows the encoding of the Tumour protein p63.
2. A research article that explores this gene is:
<pubmed>2564545</pubmed>
3. Mutations of the p63 gene are detrimental as it is a critical regulator that prevents a host of defects in development, such as ectodermal dysplasia. Without the presence of this gene in mice, the mice died at birth and had truncated limbs as well as epidermal defects[2].
In the context of cleft palate syndrome and the p63 gene, there is not a clear reason as to why mutations of the p63 gene can result in cleft palate but as cleft palate is a form of ectodermal dysplasia and functioning p63 prevents dysplasia, a connection can be made [3].
Lab Attendance
Z5015337 (talk)23/09Z5015337 (talk)
Lab 7 Assessment
1. The dystrophin gene is located on the locus of the X chromosome and is responsible for the transcription of dystrophin. A mutation of this gene will therefore result in altered expression of the muscle isoform, dystrophin[4] . Mutations like these can result in Autosomal recessive muscular dystrophy and Duchenne and Becker muscular dystrophies to name a few.
2. Dystrophin is a critical protein that is responsible for linking the actin filaments to the sarcolemma, which is a protein that is located in the interior of the plasma membrane of individual muscle fibres[5]. Dystrophin is critical in ensuring the stability of muscle fibres and without it intracellular calcium handling is altered resulting in muscular function being impaired[6].
3. Other organs that are affected by this disorder are the heart and those responsible for respiration as there is gradual loss of healthy muscular fibres which by cellular repair mechanisms are replaced with inelastic fibrous tissue resulting in less effective contractions resulting in cardiac and respiratory failure[7] .
4.
5 The animal models available for muscular dystrophy are historically the MDX mouse and more recently, a canine DMD.[8]
New Sub-Heading
External Link
Internal Link
https://embryology.med.unsw.edu.au/embryology/index.php/ANAT2341_Lab_1