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Endocrinology Textbook - Table of Contents  
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Endocrinology - An Integrated Approach Stephen Nussey and Saffron Whitehead. St. George's Hospital Medical School, London, UK Oxford: BIOS Scientific Publishers; 2001. ISBN-10: 1-85996-252-1
  1. Principles of endocrinology
    1. Functions of hormones and their regulation
    2. Chemical signalling - endocrine, paracrine, autocrine and intracrine mechanisms
    3. Chemical classification of hormones and their synthesis
    4. Hormone synthesis
    5. Transport of hormones in the circulation and their half-lives
    6. Hormone receptors - cell surface
    7. Hormone receptors - intracellular
    8. Hormones and gene transcription
    9. Hormone receptor regulation
    10. Neuroendocrine interactions
    11. Hormones and the immune system
    12. Hormones, growth promotion and malignancy
    13. Genes, mutations and endocrine function
    14. Clinical evaluation of endocrine disorders
  2. The endocrine pancreas
    1. Glucose turnover
    2. Anabolic and catabolic phases of glucose metabolism
    3. Actions of insulin and glucagon
    4. Lipid metabolism - insulinopenia and diabetic ketosis
    5. Protein metabolism and the anabolic actions of insulin
    6. Definition and diagnosis of diabetes mellitus
    7. Etiology of type 1 DM
    8. Prevention of type 1 DM
    9. Structure, synthesis and metabolism of insulin and glucagon
    10. Anatomical features of pancreatic islets in relation to hormone secretion and its control
    11. Control of insulin and glucagon secretion
    12. Type 2 DM
    13. Causes of DM
    14. Genetic disorders of β-cell function
    15. Counter-regulatory hormones and DM
    16. Complications of DM
    17. Macrovascular circulatory changes
    18. Microvascular changes - diabetic retinopathy, nephropathy and neuropathy
    19. Diabetes and the neuropathic foot
    20. Diabetes and insulin resistance of pregnancy
    21. Development of the pancreas: effects of DM on organogenesis
    22. Treatment of DM - rationale and practical considerations
    23. Hypoglycemia
    24. Physiological responses to hypoglycemia and its treatment
    25. Hypoglycemia and insulinoma
    26. Hypoglycemia in infancy
    27. Disorders of the α, γ and PP cells of the islets
    28. Clinical case questions
  3. The thyroid gland
    1. Iodine intake
    2. Anatomical features of the thyroid gland
    3. Iodine trapping and thyroid function
    4. Synthesis of thyroid hormones
    5. Actions of thyroid hormones
    6. Control of thyroid hormone synthesis and secretion
    7. Hyperthyroidism — Graves' disease
    8. Surgical anatomy and embryology of the thyroid gland
    9. Primary hypothyroidism — Hashimoto's disease and myxedema
    10. Secondary hypothyroidism
    11. Hypothyroidism in infancy and childhood
    12. Thyroid hormone resistance
    13. Non-thyroid illness (‘sick euthyroid’ syndrome)
    14. Transport and metabolism of thyroid hormones
    15. Biochemical measurements of thyroid hormone status
    16. Thyroid growth
    17. Nodular thyroid disease
    18. Thyroid cancer
    19. Clinical case questions
  4. The adrenal gland
    1. Specificity of the biological effects of adrenal steroid hormones
    2. Cholesterol and steroid synthesis in the adrenal cortex
    3. Anatomical and functional zonation in the adrenal cortex
    4. Glucocorticoid receptors
    5. Actions of glucocorticoids and clinical features of Cushing's syndrome
    6. Adrenal cortical androgens
    7. Hypothalamic control of adrenocortical steroid synthesis - CRH and vasopressin
    8. Pituitary control of adrenocortical steroids - ACTH
    9. Feedback control of glucocorticoids
    10. Excess glucocorticoids: biochemical investigation of Cushing's syndrome
    11. Measurements of cortisol in blood, urine and saliva
    12. Dynamic tests of endocrine function
    13. Imaging the adrenal gland
    14. Treatment of Cushing's syndrome
    15. Nelson's syndrome
    16. Excess adrenal androgens - congenital adrenal hyperplasia (CAH)
    17. Deficiency of adrenocortical secretions - Addison's disease
    18. Aldosterone and the control of salt and water balance
    19. Transport and metabolism of adrenocortical steroids
    20. Selective mineralocorticoid excess and deficiency
    21. The adrenal medulla and pheochromocytoma
    22. Catecholamine synthesis and secretion
    23. Diagnosis and treatment of pheochromocytomas
    24. Clinical case questions
  5. The parathyroid glands and vitamin D
    1. Calcium and phosphate in serum and its measurement
    2. Intracellular calcium concentration
    3. Calcium and phosphate balance
    4. Hormonal control of serum Ca2+ and Pi concentrations
    5. Sources, metabolism and transport of vitamin D
    6. Classical actions of vitamin D on intestine and bone
    7. Parathyroid glands and PTH synthesis
    8. Control of PTH secretion
    9. Actions of PTH
    10. Hypercalcemia and primary hyperparathyroidism
    11. Hyperparathyroidism and multiple endocrine neoplasia (MEN)
    12. Hypercalcemia and vitamin D excess
    13. Hypercalcemia and malignancy
    14. Parathyroid hormone-related peptide (PTHrp)
    15. Treatment of hypercalcemia
    16. Mutations of the Ca2+ or PTH receptors
    17. Hypocalcemia and its treatment
    18. Pseudohypoparathyroidism
    19. Vitamin D deficiency
    20. Non-classical actions of vitamin D
    21. Vitamin D resistance and rickets
    22. Hormones and the skeleton
    23. Structure, formation and function of bone
    24. Osteoporosis
    25. Paget's disease (osteitis deformans)
    26. Calcitonin and calcitonin gene-related peptide
    27. Clinical case questions
  6. The gonad
    1. Genetic determination of sexual differentiation
    2. Sexual differentiation of the gonads and internal reproductive tracts
    3. Sexual differentiation of the external genitalia
    4. Control of steroid production in the fetal gonads
    5. Puberty
    6. GnRH and the control of gonadotrophin synthesis and secretion
    7. The gonadotrophins - LH and FSH - and their actions
    8. Endocrine changes in puberty
    9. Precocious sexual development
    10. Delayed puberty
    11. Premature adrenarche
    12. Acne, hair growth and hirsutism
    13. The breast - premature development, hypoplasia and gynecomastia
    14. Testicular function
    15. Control of testicular function
    16. Transport, metabolism and actions of androgens
    17. Spermatogenesis
    18. Erection and ejaculation
    19. Ovarian control and the menstrual cycle
    20. Transport, metabolism and actions of ovarian steroids
    21. The ovary - folliculogenesis and oogenesis
    22. Non-steroidal factors in the control of the hypothalamic-pituitary-gonadal axis
    23. Ovulation, menstruation and its problems
    24. Polycystic ovary syndrome (PCOS)
    25. Contraception
    26. Infertility
    27. Ovulation induction and assisted conception
    28. Ovarian failure, the menopause and andropause
    29. Hormonal replacement therapy (HRT) and selective estrogen receptor modulators (SERMS)
    30. Clinical case questions
  7. The pituitary gland
    1. Anatomical and functional connections of the hypothalamo-pituitary axis
    2. Embryology of the pituitary gland
    3. Craniopharyngioma
    4. Blood supply of the hypothalamo-pituitary axis
    5. Sheehan's syndrome
    6. Growth and somatotrophin deficiency
    7. Growth hormone - secretory patterns and control
    8. Actions of growth hormone and insulin-like growth factors
    9. GH replacement therapy
    10. GH excess - gigantism and acromegaly
    11. Pituitary adenomas - incidence and treatment
    12. Prolactinomas
    13. Prolactin and its control
    14. Circadian rhythms and the suprachiasmatic nucleus
    15. The pineal gland and melatonin
    16. Autonomic functions of the hypothalamus
    17. Obesity
    18. The neural lobe of the pituitary gland - AVP and oxytocin
    19. Clinical case questions
  8. Cardiovascular and renal endocrinology
    1. Endocrinology of heart failure
    2. Paracrine and autocrine regulation of blood pressure: the endocrinology of sepsis
    3. Hormones and blood cell production - erythropoietin
    4. Carcinoid
    5. Clinical case questions