Sheep Development: Difference between revisions
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{{Header}} | |||
==Introduction== | ==Introduction== | ||
[[File:Sheep and lamb.jpg|thumb|Sheep with lamb with second (twin) lamb being born.]] | |||
The domestic sheep (''Ovis aries'') has been used as a mammalian model of development with a term gestational period of 145 - 150 days. | |||
[[File:Carnegie stages species comparison.jpg|500px]] | |||
<br> | |||
[[:Category:Sheep|Category:Sheep]] | |||
<br> | |||
Historic Embryology: [[Paper - The development of nerve-endings in the respiratory muscles of the sheep (1940)|1940 respiratory muscles nerve-endings]] | |||
<br><br> | |||
{{Animal development period table}} | |||
== Some Recent Findings == | == Some Recent Findings == | ||
{| | {| | ||
|-bgcolor="F5FAFF" | |-bgcolor="F5FAFF" | ||
| | | | ||
* '''Development of morulae from the oocytes of cultured sheep preantral follicles''' | * '''Healthy ageing of cloned sheep'''{{#pmid:27459299|PMID27459299}} "The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7-9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5-and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals." [[Somatic Cell Nuclear Transfer]] | ||
* '''Development of morulae from the oocytes of cultured sheep preantral follicles'''{{#pmid:20615540|PMID20615540}} "Sheep preantral follicles (PFs) measuring 250-400 microm in diameter were cultured for six days in serum-free media supplemented differently with growth factors and hormones. ...In combination with T4 and FSH, IGF-I+GH supported the best development of the PFs. Culture of PFs in micro drops or agar gel supported similarly high development. In vitro fertilization of the oocytes from the cultured sheep PFs resulted in the embryos developing to the morula stage for the first time." | |||
|} | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! More recent papers | |||
|- | |||
| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | |||
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Sheep+Development ''Sheep Development''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Sheep+Embryology ''Sheep Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Ovine+Development ''Ovine Development''] | |||
|} | |||
{| class="wikitable mw-collapsible mw-collapsed" | |||
! Older papers | |||
|- | |||
| {{Older papers}} | |||
* '''Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model'''{{#pmid:20610723|PMID20610723}} | |||
|} | |||
==Development Overview== | |||
[[File:Sheep follicle in vitro 01.jpg|thumb|Sheep follicle in vitro{{#pmid:22132111|PMID22132111}}]] | |||
{| | |||
! Day | |||
! Event | |||
|- | |||
| 4 | |||
| embryo enters the uterus at the {{morula}} stage | |||
|- | |||
| 6 | |||
| {{blastocyst}} stage | |||
|- | |||
| 8 | |||
| {{blastocyst}} hatches from {{zona pellucida}} | |||
|- | |||
| 11-16 | |||
| elongates to a filamentous form | |||
|- | |||
| 14 - 16 | |||
| binucleate cells begin to differentiate in the {{trophoblast}} | |||
|- | |||
| 16 | |||
| {{adplantation}} | |||
|} | |||
See also Implantation mechanisms: insights from the sheep{{#pmid:15579583|PMID15579583}} | |||
==Dolly== | |||
[[File:Dolly_the_sheep.jpg|thumb|Dolly the sheep (5 July 1996 – 14 February 2003)]] | |||
A female domestic sheep remarkable in being the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer.{{#pmid:9039911|PMID9039911}} | |||
Cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute near Edinburgh in Scotland, born on 5 July 1996 and she lived until the age of six (5 July 1996 – 14 February 2003). The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. As Dolly was cloned from part of a mammary gland, she was named after the famously curvaceous country western singer Dolly Parton. | |||
:'''Links:''' [http://www.roslin.ac.uk/public/cloning.html Roslin Institute, Edinburgh] | [http://www.sciencemuseum.org.uk/antenna/dolly/index.asp Science Museum - Dolly the sheep, 1996-2003] | |||
==Oocyte Development== | |||
[[File:Sheep follicle gene expression 01.jpg|600px]] | |||
{| | |||
| Sheep follicle gene expression{{#pmid:26540452|PMID26540452}} | |||
| width=300px| | |||
* <font color=red>'''red'''</font> - genes expressed in granulose cells. | |||
* <font color=blue>'''blue'''</font> - genes expressed in oocytes. | |||
* '''black''' - genes expressed both in oocytes and granulosa cells. | |||
|} | |} | ||
===Sheep Oocyte Distribution of Telomerase reverse transcriptase=== | |||
The following oocyte images are from a recent study of sheep in vitro follicle development.{{#pmid:22132111|PMID22132111}} | |||
{| | |||
| [[File:Sheep oocyte 01.jpg|300px]] | |||
| [[File:Sheep oocyte 02.jpg|300px]] | |||
|- | |||
| preantral | |||
| early antral | |||
|- | |||
| [[File:Sheep oocyte 03.jpg|300px]] | |||
| [[File:Sheep oocyte 04.jpg|300px]] | |||
|- | |||
| early antral | |||
| preovulatory follicle | |||
|} | |||
{{Sheep_Oocyte_TERT}} | |||
==Respiratory== | |||
Phases of fetal lung development:{{#pmid:15774522|PMID15774522}} | |||
# embryonic - 0 to 40 days. | |||
# pseudoglandular - 40 to 80 days. | |||
# canalicular - 80 to 120 days. | |||
# saccular - 120 to term 148 days gestation. | |||
:'''Links:''' [[Respiratory System Development|Respiratory Development]] | |||
==Immune== | |||
Lymphocytes development has been characterised by an immunohistology study of T lymphocytes in the sheep fetal spleen.{{#pmid:3308689|PMID3308689}} | |||
{| | |||
! Day (days of gestation) | |||
! Event | |||
|- | |||
| 43 - 44 | |||
| SBU-T1- and SBU-T8-positive lymphocytes were present in low numbers. | |||
|- | |||
| 45 - 50 | |||
| Surface immunoglobulin (sIg) was first detected on fetal spleen cells | |||
|- | |||
| 50 - 55 | |||
| SBU-T4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes present. | |||
|- | |||
| 57 | |||
| SBU-T19 lymphocytes appeared. | |||
|} | |||
:'''Links:''' [[Immune System Development|Immune Development]] | |||
==References== | ==References== | ||
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<references/> | <references/> | ||
===Reviews=== | |||
{{#pmid:32094003}} | |||
{{#pmid:31877963}} | |||
{{#pmid:19726075}} | |||
{{#pmid:16008756}} | |||
===Articles=== | ===Articles=== | ||
{{#pmid:19909921}} | |||
{{#pmid:15047940}} | |||
===Search PubMed=== | ===Search PubMed=== | ||
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'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=sheep%20development sheep development] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=ovine%20development ovine development] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=ovine%20embryo%20development ovine embryo development] | '''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=sheep%20development sheep development] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=ovine%20development ovine development] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=ovine%20embryo%20development ovine embryo development] | ||
==External Links== | |||
{{External Links}} | |||
* [http://139.78.104.1/breeds/sheep Oklahoma State University - breeds of sheep] | |||
{{Animals}} | |||
{{ | {{Glossary}} | ||
{{ | {{Footer}} | ||
[[Category:Sheep]] |
Latest revision as of 14:27, 5 April 2020
Embryology - 17 Jun 2024 Expand to Translate |
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Introduction
The domestic sheep (Ovis aries) has been used as a mammalian model of development with a term gestational period of 145 - 150 days.
Category:Sheep
Historic Embryology: 1940 respiratory muscles nerve-endings
Animal Development Time | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Animal Notes and Table Data Sources
|
Some Recent Findings
|
More recent papers |
---|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Sheep Development | Sheep Embryology | Ovine Development |
Older papers |
---|
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
|
Development Overview
Day | Event |
---|---|
4 | embryo enters the uterus at the morula stage |
6 | blastocyst stage |
8 | blastocyst hatches from zona pellucida |
11-16 | elongates to a filamentous form |
14 - 16 | binucleate cells begin to differentiate in the trophoblast |
16 | adplantation |
See also Implantation mechanisms: insights from the sheep[5]
Dolly
A female domestic sheep remarkable in being the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer.[6]
Cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute near Edinburgh in Scotland, born on 5 July 1996 and she lived until the age of six (5 July 1996 – 14 February 2003). The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. As Dolly was cloned from part of a mammary gland, she was named after the famously curvaceous country western singer Dolly Parton.
Oocyte Development
Sheep follicle gene expression[7] |
|
Sheep Oocyte Distribution of Telomerase reverse transcriptase
The following oocyte images are from a recent study of sheep in vitro follicle development.[4]
preantral | early antral |
early antral | preovulatory follicle |
- TERT - Red (Cy3-conjugated secondary antibody) (telomerase reverse transcriptase, TERT)
- DNA - Green (SYBR Green 14/I)
- Sheep Oocyte TERT: preantral | early antral | early antral | preovulatory follicle | Oocyte Development | Sheep Development
Respiratory
Phases of fetal lung development:[8]
- embryonic - 0 to 40 days.
- pseudoglandular - 40 to 80 days.
- canalicular - 80 to 120 days.
- saccular - 120 to term 148 days gestation.
- Links: Respiratory Development
Immune
Lymphocytes development has been characterised by an immunohistology study of T lymphocytes in the sheep fetal spleen.[9]
Day (days of gestation) | Event |
---|---|
43 - 44 | SBU-T1- and SBU-T8-positive lymphocytes were present in low numbers. |
45 - 50 | Surface immunoglobulin (sIg) was first detected on fetal spleen cells |
50 - 55 | SBU-T4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes present. |
57 | SBU-T19 lymphocytes appeared. |
- Links: Immune Development
References
- ↑ Sinclair KD, Corr SA, Gutierrez CG, Fisher PA, Lee JH, Rathbone AJ, Choi I, Campbell KH & Gardner DS. (2016). Healthy ageing of cloned sheep. Nat Commun , 7, 12359. PMID: 27459299 DOI.
- ↑ Arunakumari G, Shanmugasundaram N & Rao VH. (2010). Development of morulae from the oocytes of cultured sheep preantral follicles. Theriogenology , 74, 884-94. PMID: 20615540 DOI.
- ↑ Black SG, Arnaud F, Burghardt RC, Satterfield MC, Fleming JA, Long CR, Hanna C, Murphy L, Biek R, Palmarini M & Spencer TE. (2010). Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model. J. Virol. , 84, 9078-85. PMID: 20610723 DOI.
- ↑ 4.0 4.1 Barboni B, Russo V, Cecconi S, Curini V, Colosimo A, Garofalo ML, Capacchietti G, Di Giacinto O & Mattioli M. (2011). In vitro grown sheep preantral follicles yield oocytes with normal nuclear-epigenetic maturation. PLoS ONE , 6, e27550. PMID: 22132111 DOI.
- ↑ Spencer TE, Johnson GA, Bazer FW & Burghardt RC. (2004). Implantation mechanisms: insights from the sheep. Reproduction , 128, 657-68. PMID: 15579583 DOI.
- ↑ Wilmut I, Schnieke AE, McWhir J, Kind AJ & Campbell KH. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature , 385, 810-3. PMID: 9039911 DOI.
- ↑ Bonnet A, Servin B, Mulsant P & Mandon-Pepin B. (2015). Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth. PLoS ONE , 10, e0141482. PMID: 26540452 DOI.
- ↑ Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME & Stephenson T. (2005). Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung. J. Physiol. (Lond.) , 565, 159-69. PMID: 15774522 DOI.
- ↑ Maddox JF, Mackay CR & Brandon MR. (1987). Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology , 62, 107-12. PMID: 3308689
Reviews
Thompson RP, Nilsson E & Skinner MK. (2020). Environmental epigenetics and epigenetic inheritance in domestic farm animals. Anim. Reprod. Sci. , , 106316. PMID: 32094003 DOI.
Gebreselassie G, Berihulay H, Jiang L & Ma Y. (2019). Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries). Animals (Basel) , 10, . PMID: 31877963 DOI.
Lazzari G, Colleoni S, Lagutina I, Crotti G, Turini P, Tessaro I, Brunetti D, Duchi R & Galli C. (2010). Short-term and long-term effects of embryo culture in the surrogate sheep oviduct versus in vitro culture for different domestic species. Theriogenology , 73, 748-57. PMID: 19726075 DOI.
Campbell KH, Alberio R, Choi I, Fisher P, Kelly RD, Lee JH & Maalouf W. (2005). Cloning: eight years after Dolly. Reprod. Domest. Anim. , 40, 256-68. PMID: 16008756 DOI.
Articles
Wang J, Guillomot M & Hue I. (2009). Cellular organization of the trophoblastic epithelium in elongating conceptuses of ruminants. C. R. Biol. , 332, 986-97. PMID: 19909921 DOI.
Guillomot M, Turbe A, Hue I & Renard JP. (2004). Staging of ovine embryos and expression of the T-box genes Brachyury and Eomesodermin around gastrulation. Reproduction , 127, 491-501. PMID: 15047940 DOI.
Search PubMed
Search Pubmed: sheep development | ovine development | ovine embryo development
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Cite this page: Hill, M.A. (2024, June 17) Embryology Sheep Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sheep_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G