Developmental Signals - basic Helix-Loop-Helix: Difference between revisions
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===Neural=== | ===Neural=== | ||
{{neural}} | |||
===Hearing=== | |||
Mouse organ of Corti development requires Neurod1{{#pmid:20661473|PMID20661473}} | |||
[[File:Mouse organ of corti NeuroD1.jpg|600px]] | |||
:Links: {{inner ear}} | {{hearing}} | |||
===Axial Skeleton=== | ===Axial Skeleton=== | ||
===Limb=== | ===Limb=== | ||
{{limb}} | |||
===Other=== | ===Other=== | ||
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{{Footer}} | {{Footer}} | ||
[[Category:bHLH]] | |||
[[Category:Molecular]] [[Category:Pattern]] | [[Category:Molecular]][[Category:Pattern]] | ||
[[Category:Neural]] | [[Category:Neural]] | ||
[[Category:Transcription Factor]] | [[Category:Transcription Factor]] |
Latest revision as of 18:33, 30 July 2018
Embryology - 15 Jun 2024 Expand to Translate |
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Introduction
The family of basic Helix-Loop-Helix (bHLH) transcription factors is encoded in humans between 110 to 125 genes, compared with only 59 in the fly (Drosophila).[1] The structural motif describing this transcription factor family refers to the two α-helices connected by a loop. These transcription factors are generally domain are dimeric, with each helix containing basic amino acid residues that aid DNA binding.
This signalling pathway has also been implicated in many developmental abnormalities and diseases.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Hox <pubmed limit=5>Hox</pubmed> |
Older papers |
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Classification
Human Genes
Table - basic Helix Loop Helix Factor Family bHLH | |||||
Approved Symbol |
Approved Name | Previous Symbols |
Synonyms | Chromosome | |
---|---|---|---|---|---|
NEUROD2 | neuronal differentiation 2 | bHLHa1, NDRF | 17q12 | ||
NEUROD6 | neuronal differentiation 6 | Nex1, Math-2, bHLHa2, NEX1M, Atoh2 | 7p14.3 | ||
NEUROD1 | neuronal differentiation 1 | NEUROD | MODY6, bHLHa3, NeuroD, BHF-1, BETA2 | 2q31.3 | |
NEUROD4 | neuronal differentiation 4 | Atoh3, MATH-3, ATH-3, bHLHa4 | 12q13.13 | ||
NEUROG1 | neurogenin 1 | NEUROD3 | bHLHa6, Math4C, ngn1, AKA | 5q31.1 | |
NEUROG3 | neurogenin 3 | Math4B, Atoh5, ngn3, bHLHa7 | 10q22.1 | ||
NEUROG2 | neurogenin 2 | Atoh4, bHLHa8, ngn-2, NGN2, Math4A | 4q25 | ||
BHLHA9 | basic helix-loop-helix family member a9 | bHLHa9, BHLHF42 | 17p13.3 | ||
ATOH7 | atonal bHLH transcription factor 7 | Math5, bHLHa13 | 10q21.3 | ||
ATOH1 | atonal bHLH transcription factor 1 | MATH-1, bHLHa14, Math1, HATH1 | 4q22.2 | ||
BHLHA15 | basic helix-loop-helix family member a15 | BHLHB8 | MIST1, bHLHa15 | 7q21.3 | |
TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | TCL5 | SCL, bHLHa17 | 1p33 | |
LYL1 | LYL1, basic helix-loop-helix family member | bHLHa18 | 19p13.13 | ||
TAL2 | TAL bHLH transcription factor 2 | bHLHa19 | 9q31.2 | ||
ATOH8 | atonal bHLH transcription factor 8 | bHLHa21, HATH6, FLJ14708 | 2p11.2 | ||
MSC | musculin | bHLHa22, ABF-1 | 8q13.3 | ||
TCF21 | transcription factor 21 | bHLHa23, POD1 | 6q23.2 | ||
TCF23 | transcription factor 23 | bHLHa24, OUT | 2p23.3 | ||
TCF24 | transcription factor 24 | bHLHa25 | 8q13.1 | ||
HAND2 | heart and neural crest derivatives expressed 2 | bHLHa26, Thing2, Hed, dHand | 4q34.1 | ||
HAND1 | heart and neural crest derivatives expressed 1 | Hxt, Thing1, eHand, bHLHa27 | 5q33.2 | ||
PTF1A | pancreas associated transcription factor 1a | p48, bHLHa29, PTF1-p48 | 10p12.2 | ||
PERD3L | Fer3 like bHLH transcription factor | N-TWIST, bHLHa31, NATO3 | 7p21.1 | ||
NHLH2 | nescient helix-loop-helix 2 | HEN2 | bHLHa34, NSCL2 | 1p13.1 | |
NHLH1 | nescient helix-loop-helix 1 | HEN1 | bHLHa35, NSCL, NSCL1 | 1q23.2 | |
TWIST1 | twist family bHLH transcription factor 1 | ACS3, BPES3, TWIST, CRS | bHLHa38, H-twist, SCS, CRS1, BPES2 | 7p21.1 | |
TWIST2 | twist family bHLH transcription factor 2 | bHLHa39, Dermo-1, DERMO1 | 2q37.3 | ||
TCF15 | transcription factor 15 | bHLHa40, PARAXIS, EC2 | 20p13 | ||
ASCL3 | achaete-scute family bHLH transcription factor 3 | HASH3, bHLHa42, Sgn1 | 11p15.4 | ||
ASCL4 | achaete-scute family bHLH transcription factor 4 | bHLHa44, HASH4 | 12q23.3 | ||
ASCL2 | achaete-scute family bHLH transcription factor 2 | ASH2, bHLHa45, HASH2 | 11p15.5 | ||
ASCL1 | achaete-scute family bHLH transcription factor 1 | bHLHa46, HASH1, ASH1 | 12q23.2 | ||
ASCL5 | achaete-scute family bHLH transcription factor 5 | bHLHa47 | 1q32.1 | ||
SCX | scleraxis bHLH transcription factor | SCXA, SCXB | bHLHa41, bHLHa48 | 8q24.3 | |
BHLHB9 | basic helix-loop-helix family member b9 | p60TRP, KIAA1701, GASP3 | Xq22.1 | ||
USF1 | upstream transcription factor 1 | bHLHb11, UEF, MLTFI | 1q23.3 | ||
USF2 | upstream transcription factor 2, c-fos interacting | FIP, bHLHb12 | 19q13 | ||
TCF4 | transcription factor 4 | SEF2-1B, ITF2, bHLHb19, E2-2 | 18q21.2 | ||
TCF12 | transcription factor 12 | HsT17266, p64, HTF4, bHLHb20, HEB | 15q21.3 | ||
TCF3 | transcription factor 3 | MGC129647, bHLHb21, p75, E2A, VDIR, E47, MGC129648, ITF1 | 19p13.3 | ||
ID1 | inhibitor of DNA binding 1, HLH protein | bHLHb24, dJ857M17.1.2 | 20q11.21 | ||
ID3 | inhibitor of DNA binding 3, HLH protein | bHLHb25, HEIR-1 | 1p36.12 | ||
ID2 | inhibitor of DNA binding 2 | GIG8, bHLHb26 | 2p25.1 | ||
ID4 | inhibitor of DNA binding 4, HLH protein | bHLHb27 | 6p22.3 | ||
HEY1 | hes related family bHLH transcription factor with YRPW motif 1 | bHLHb31, CHF-2, HRT-1, HESR1, CHF2, HERP2, HESR-1 | 8q21.13 | ||
HEY2 | hes related family bHLH transcription factor with YRPW motif 2 | bHLHb32, HESR2, HERP1 | 6q22.31 | ||
HEYL | hes related family bHLH transcription factor with YRPW motif-like | HEY3, HESR3, bHLHb33 | 1p34.2 | ||
HES7 | hes family bHLH transcription factor 7 | bHLHb37 | 17p13.1 | ||
HES5 | hes family bHLH transcription factor 5 | bHLHb38 | 1p36.32 | ||
HES1 | hes family bHLH transcription factor 1 | HRY | HES-1, Hes1, bHLHb39, FLJ20408 | 3q29 | |
HES2 | hes family bHLH transcription factor 2 | bHLHb40 | 1p36.31 | ||
HES6 | hes family bHLH transcription factor 6 | bHLHb41 | 2q37.3 | ||
HES4 | hes family bHLH transcription factor 4 | bHLHb42 | 1p36.33 | ||
HES3 | hes family bHLH transcription factor 3 | bHLHb43 | 1p36.31 | ||
HELT | helt bHLH transcription factor | bHLHb44, HESL, HCM1228, MEGANE, Mgn | 4q35.1 | ||
MYOD1 | myogenic differentiation 1 | MYF3 | PUM, bHLHc1, MYOD | 11p15.1 | |
MYF5 | myogenic factor 5 | bHLHc2 | 12q21.31 | ||
MYOG | myogenin | MYF4 | bHLHc3 | 1q32.1 | |
MYF6 | myogenic factor 6 | MRF4, bHLHc4 | 12q21.31 | ||
MESP1 | mesoderm posterior bHLH transcription factor 1 | bHLHc5, MGC10676 | 15q26.1 | ||
MESP2 | mesoderm posterior bHLH transcription factor 2 | SCDO2, bHLHc6 | 15q26.1 | ||
FIGLA | folliculogenesis specific bHLH transcription factor | bHLHc8 | 2p13.3 | ||
MXI1 | MAX interactor 1, dimerization protein | MAD2, MXI, MXD2, bHLHc11 | 10q25.2 | ||
MXD4 | MAX dimerization protein 4 | bHLHc12, MST149, MSTP149, MAD4 | 4p16.3 | ||
MXD3 | MAX dimerization protein 3 | bHLHc13, MAD3 | 5q35.3 | ||
TFAP4 | transcription factor AP-4 | bHLHc41, AP-4 | 16p13.3 | ||
MXD1 | MAX dimerization protein 1 | MAD | bHLHc58, MAD1 | 2p13.3 | |
SREBF1 | sterol regulatory element binding transcription factor 1 | SREBP1a, SREBP1, SREBP-1c, bHLHd1 | 17p11.2 | ||
SREBF2 | sterol regulatory element binding transcription factor 2 | bHLHd2, SREBP2 | 22q13.2 | ||
MNT | MAX network transcriptional repressor | ROX, MXD6, MAD6, bHLHd3 | 17p13.3 | ||
MAX | MYC associated factor X | bHLHd7, bHLHd5, bHLHd8, bHLHd6, bHLHd4 | 14q23.3 | ||
MLX | MLX, MAX dimerization protein | TCFL4 | bHLHd13, MXD7, MAD7 | 17q21.1 | |
MLXIPL | MLX interacting protein like | WBSCR14 | bHLHd14, MONDOB, MIO, WS-bHLH, CHREBP | 7q11.23 | |
ARNT2 | aryl hydrocarbon receptor nuclear translocator 2 | KIAA0307, bHLHe1 | 15q25.1 | ||
ARNT | aryl hydrocarbon receptor nuclear translocator | bHLHe2, HIF-1beta | 1q21.3 | ||
ARNTL | aryl hydrocarbon receptor nuclear translocator like | PASD3, BMAL1, MOP3, JAP3, bHLHe5 | 11p15.3 | ||
ARNTL2 | aryl hydrocarbon receptor nuclear translocator like 2 | MOP9, bHLHe6, PASD9, CLIF, BMAL2 | 12p11.23 | ||
CLOCK | clock circadian regulator | KIAA0334, bHLHe8, KAT13D | 4q12 | ||
NPAS2 | neuronal PAS domain protein 2 | PASD4, MOP4, bHLHe9 | 2q11.2 | ||
NPAS1 | neuronal PAS domain protein 1 | bHLHe11, MOP5, PASD5 | 19q13.32 | ||
NPAS3 | neuronal PAS domain protein 3 | MOP6, bHLHe12, PASD6 | 14q13.1 | ||
SIM1 | SIM bHLH transcription factor 1 | bHLHe14 | 6q16.3 | ||
SIM2 | SIM bHLH transcription factor 2 | SIM | MGC119447, bHLHe15 | 21q22.13 | |
HIF3A | hypoxia inducible factor 3 subunit alpha | MOP7, IPAS, bHLHe17, PASD7 | 19q13.32 | ||
OLIG2 | oligodendrocyte transcription factor 2 | PRKCBP2, BHLHB1 | OLIGO2, RACK17, bHLHe19 | 21q22.11 | |
OLIG3 | oligodendrocyte transcription factor 3 | bHLHe20, Bhlhb7 | 6q23.3 | ||
OLIG1 | oligodendrocyte transcription factor 1 | BHLHB6, bHLHe21 | 21q22.11 | ||
BHLHE22 | basic helix-loop-helix family member e22 | TNRC20, BHLHB5 | CAGL85, Beta3, bHLHe22 | 8q12.3 | |
BHLHE23 | basic helix-loop-helix family member e23 | BHLHB4 | bA305P22.3, Beta4, bHLHe23 | 20q13.33 | |
MITF | melanogenesis associated transcription factor | WS2A, WS2 | bHLHe32, MI | 3p13 | |
TFE3 | transcription factor binding to IGHM enhancer 3 | TFEA, bHLHe33 | Xp11.23 | ||
TFEC | transcription factor EC | bHLHe34, TCFEC, TFECL | 7q31.2 | ||
TFEB | transcription factor EB | bHLHe35, TCFEB | 6p21.1 | ||
MLXIP | MLX interacting protein | MIR, KIAA0867, bHLHe36, MONDOA | 12q21.31 | ||
MYCN | MYCN proto-oncogene, bHLH transcription factor | NMYC | bHLHe37, N-myc, MYCNOT | 2p24.3 | |
MYCL | MYCL proto-oncogene, bHLH transcription factor | MYCL1 | bHLHe38, LMYC | 1p34.2 | |
MYC | MYC proto-oncogene, bHLH transcription factor | MYCC, bHLHe39, c-Myc | 8q24.21 | ||
BHLHE40 | basic helix-loop-helix family member e40 | STRA13, BHLHB2 | DEC1, bHLHe40, SHARP2, Clast5 | 3p26.1 | |
BHLHE41 | basic helix-loop-helix family member e41 | BHLHB3 | DEC2, SHARP-1, SHARP1, bHLHe41 | 12p12.1 | |
NCOA3 | nuclear receptor coactivator 3 | SRC-3, KAT13B, CAGH16, ACTR, p/CIP, bHLHe42, TRAM-1, AIB1, TNRC16, SRC3, RAC3 | 20q13.12 | ||
EPAS1 | endothelial PAS domain protein 1 | HLF, HIF2A, bHLHe73, MOP2, PASD2 | 2p21 | ||
NCOA1 | nuclear receptor coactivator 1 | RIP160, bHLHe74, NCoA-1, F-SRC-1, SRC1, KAT13A | 2p23.3 | ||
NCOA2 | nuclear receptor coactivator 2 | TIF2, bHLHe75, NCoA-2, GRIP1, KAT13C | 8q13.3 | ||
AHR | aryl hydrocarbon receptor | bHLHe76 | 7p21.1 | ||
AHRR | aryl-hydrocarbon receptor repressor | AHH, AHHR | KIAA1234, bHLHe77 | 5p15.33 | |
HIF1A | hypoxia inducible factor 1 subunit alpha | bHLHe78, HIF1, HIF-1alpha, MOP1, PASD8 | 14q23.2 | ||
NPAS4 | neuronal PAS domain protein 4 | bHLHe79, Le-PAS, NXF, PASD10 | 11q13.2 | ||
SOHLH1 | spermatogenesis and oogenesis specific basic helix-loop-helix 1 | C9orf157 | NOHLH, bA100C15.3, SPATA27, bHLHe80, TEB2 | 9q34.3 | |
SOHLH2 | spermatogenesis and oogenesis specific basic helix-loop-helix 2 | TEB1, SPATA28, bHLHe81, FLJ20449 | 13q13.3 | ||
TCFL5 | transcription factor like 5 | CHA, E2BP-1, bHLHe82, Figlb | 20q13.33 | ||
Links: Developmental Signals - basic Helix-Loop-Helix | HGNC | Bmp Family | Fgf Family | Sox Family | Tbx Family |
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Functions
Developmental patterning signal.
Neural
Hearing
Mouse organ of Corti development requires Neurod1[2]
Axial Skeleton
Limb
Other
Signaling Pathway
References
- ↑ Baker NE & Brown NL. (2018). All in the family: proneural bHLH genes and neuronal diversity. Development , 145, . PMID: 29720483 DOI.
- ↑ Jahan I, Pan N, Kersigo J & Fritzsch B. (2010). Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea. PLoS ONE , 5, e11661. PMID: 20661473 DOI.
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Cite this page: Hill, M.A. (2024, June 15) Embryology Developmental Signals - basic Helix-Loop-Helix. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_basic_Helix-Loop-Helix
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G