Respiratory System - Molecular
|Embryology - 20 Mar 2019 Expand to Translate|
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|Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular|
|Mechanism Links: epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | cell migration | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
<pubmed limit=5>lung molecular development</pubmed>
Fibroblast Growth Factor
Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.
Fibroblast growth factor 10 (FGF10) and sonic hedgehog (SHH) form a feedback loop for branching
- mesenchyme produced FGF10 signals to the distal epithelium to upregulate SHH expression.
- SHH then feeds back to inhibit Fgf10 expression in the adjacent mesenchyme, dividing in two the Fgf10 expression domain.
- new FGF10 signaling domains serve as two chemoattractant sources, leading to bifurcation of the epithelial tip.
Loop process mediated through FGF-activated transcription factor genes Etv4 and Etv5.
- Links: sonic hedgehog|SHH
Lipid-containing alveolar interstitial fibroblasts (lipofibroblasts) aid the type 2 alveolar epithelial cells in producing surfactant during neonatal life. A recent study in mouse shows FGF10 is required for this cell population to develop using Fgfr1b and Fgfr2b receptors.
- StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008-. Specification and patterning of the respiratory system
<pubmed></pubmed> <pubmed>25329576</pubmed> <pubmed>25556243</pubmed> <pubmed>24449833</pubmed> <pubmed></pubmed>
Search Bookshelf Fibroblast growth factor 10
Search Pubmed Now: Fibroblast growth factor 10
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Cite this page: Hill, M.A. (2019, March 20) Embryology Respiratory System - Molecular. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Respiratory_System_-_Molecular
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G