Week 4

From Embryology
Revision as of 11:58, 5 August 2009 by S8600021 (talk | contribs)

Key Events of Human Development during the forth week (week 4) following fertilization.


Week 4

Week 4 (Clinical Week 6)


Day
Stage
Event
22
Stage 10 File:CST10A.gif File:CST10B.gif

Neural Crest differentiation at spinal cord level from day 22 until day 26

Neural neural folds begin to fuse near the junction between brain and spinal cord, when Neural Crest cells are arising mainly from the neural ectoderm

Neural Crest trigeminal, facial, and postotic ganglia components visible PMID: 17848161

Neural Crest migration of vagal level neural crest cells begins (7-10 somite stage)

Brain rostral neural tube forms 3 primary brain vesicles (week 4)

Respire Week 4 - laryngotracheal groove forms on floor foregut.

23
  Heart begins to beat in Humans by day 22-23, first functioning embryonic organ formed.
24
Stage 11 File:CST11.gif

Thyroid thyroid median endodermal thickening in the floor of pharynx

Neural rostral (or cephalic) neuropore closes within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in two areas simultaneously. The two lips, however, behave differently.

Optic ventricle appears

25
Stage 12 File:CST12.gif

[endocrine7.htm Pituitary ]Week 4 hypophysial pouch, Rathke’s pouch, diverticulum from roof

GIT - Liver septum transversum forming liver stroma and hepatic diverticulum forming hepatic trabeculae PMID: 9407542

Neural caudal neuropore takes a day to close (closure is approximately at future somitic pair 31/sacral vertebra 2)

Neural secondary neurulation begins

Neural Crest cardiac crest, neural crest from rhombomeres 6 and 7 that migrates to pharyngeal arch 3 and from there the truncus arteriosus PMID: 17848161

Neural Crest vagal neural crest enter the foregut (20-25 somite stage)

26
   
27
   
28
Stage 13 File:CST13.gifNeural the neural tube is normally completely closed, ventricular system now separated from amniotic fluid. Neural crest at spinal level is segregating, and spinal ganglia are in series with the somites. Spinal cord ventral roots beginning to develop. PMID: 3354839

telencephalon cavity appears

GIT - Liver epithelial cord proliferation enmeshing stromal capillaries PMID: 9407542

Sense - Smell Crest comes from the nasal platesPMID: 15604533

Skin 4 weeks - simple ectoderm epithelium over mesenchyme

Skin 1-3 months ectoderm- germinative (basal) cell repeated division of generates stratified epithelium; mesoderm- differentiates into connective tissue and blood vessels

Carnegie Stages Link

1 | 3 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23

Glossary Links

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Dr Mark Hill 2009, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G