Vision - Cornea Development: Difference between revisions
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==Frog Cornea== | |||
This developmental timeline is from a recent Xenopus laevis cornea study<ref name=PMID23896054><pubmed>23896054</pubmed>| [http://www.sciencedirect.com/science/article/pii/S0014483513002194 Exp Eye Res.]</ref> | |||
* '''stage 25''' - cornea starts from a simple embryonic epidermis overlying the developing optic vesicle. | |||
* '''stage 30''' - detachment of the lens placode, cranial neural crest cells start to invade the space between the lens and the embryonic epidermis to construct the corneal endothelium. | |||
* '''stage 41''' - a second wave of migratory cells containing presumptive keratocytes invades the matrix leading to the formation of inner cornea and outer cornea. A unique cell mass (stroma attracting center) connects the two layers like the center pole of a tent. | |||
* '''stage 48''' - many secondary stromal keratocytes individually migrate to the center and form the stroma layer. | |||
* '''stage 60''' - the stroma space is filled by collagen lamellae and keratocytes, and the stroma attracting center disappears. At early metamorphosis, the embryonic epithelium gradually changes to the adult corneal epithelium, which is covered by microvilli. | |||
* '''stage 62''' - the embryonic epithelium thickens and cell death is observed in the epithelium, coinciding with eyelid opening. | |||
* '''After metamorphosis''' - cornea has attained the adult structure of three cellular layers, epithelium, stroma, and endothelium, and between the cellular layers lie two acellular layers (Bowman's layer and Descemet's membrane) | |||
:'''Links:''' [[Frog Development]] | |||
==Cornea Epithelia== | |||
{| | |||
| [[File:Corneal_epithelial_cells_01.jpg|alt=Corneal Epithelial Cells cartoon|400px]] | |||
Corneal epithelial cells cartoon<pubmed>19668514</pubmed> | |||
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}} | |||
==Carnegie Stages - Eye== | |||
The following data is from a study of human embryonic carnegie stages<ref><pubmed>7364662</pubmed></ref> and other sources. | The following data is from a study of human embryonic carnegie stages<ref><pubmed>7364662</pubmed></ref> and other sources. | ||
* [[Carnegie_stage_10|Stage 10]] - optic primordia appear. | * [[Carnegie_stage_10|Stage 10]] - optic primordia appear. | ||
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* [[Carnegie_stage_23|Stage 23]] - The retina comprises the pigmented layer, external limiting membrane, proliferative zone, external neuroblastic layer, transient fiber layer, internal neuroblastic layer, nerve fiber layer, and internal limiting membrane. Eyelids closure is complete (Note - shown as still open in the Kyoto embryo). | * [[Carnegie_stage_23|Stage 23]] - The retina comprises the pigmented layer, external limiting membrane, proliferative zone, external neuroblastic layer, transient fiber layer, internal neuroblastic layer, nerve fiber layer, and internal limiting membrane. Eyelids closure is complete (Note - shown as still open in the Kyoto embryo). | ||
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{{Footer}} | {{Footer}} | ||
[[Category:Vision]] | [[Category:Vision]][[Category:Cornea]] |
Revision as of 11:52, 30 August 2014
Embryology - 6 May 2024 Expand to Translate |
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Introduction
These notes introduce the development of the cornea of the eye. The adult cornea has three layers: an outer epithelium layer, a middle stromal layer of collagen-rich extracellular matrix between keratocytes and an inner layer of endothelial cells.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Cornea Development <pubmed limit=5>Cornea Development</pubmed> Search term: Cornea Embryology <pubmed limit=5>Cornea Embryology</pubmed> |
Frog Cornea
This developmental timeline is from a recent Xenopus laevis cornea study[2]
- stage 25 - cornea starts from a simple embryonic epidermis overlying the developing optic vesicle.
- stage 30 - detachment of the lens placode, cranial neural crest cells start to invade the space between the lens and the embryonic epidermis to construct the corneal endothelium.
- stage 41 - a second wave of migratory cells containing presumptive keratocytes invades the matrix leading to the formation of inner cornea and outer cornea. A unique cell mass (stroma attracting center) connects the two layers like the center pole of a tent.
- stage 48 - many secondary stromal keratocytes individually migrate to the center and form the stroma layer.
- stage 60 - the stroma space is filled by collagen lamellae and keratocytes, and the stroma attracting center disappears. At early metamorphosis, the embryonic epithelium gradually changes to the adult corneal epithelium, which is covered by microvilli.
- stage 62 - the embryonic epithelium thickens and cell death is observed in the epithelium, coinciding with eyelid opening.
- After metamorphosis - cornea has attained the adult structure of three cellular layers, epithelium, stroma, and endothelium, and between the cellular layers lie two acellular layers (Bowman's layer and Descemet's membrane)
- Links: Frog Development
Cornea Epithelia
Corneal epithelial cells cartoon<pubmed>19668514</pubmed> |
}} Carnegie Stages - EyeThe following data is from a study of human embryonic carnegie stages[3] and other sources.
Additional ImagesHistoric ImagesReferences
Reviews<pubmed></pubmed> <pubmed>23819758</pubmed> <pubmed>20599432</pubmed>| PMC3726544 <pubmed>19343693</pubmed>
Articles<pubmed></pubmed> <pubmed></pubmed> <pubmed>13429485</pubmed>| PMC1358888
Bookshelf cornea development Search PubmedSearch Pubmed: cornea development
TermsExternal LinksExternal Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Glossary Links
Cite this page: Hill, M.A. (2024, May 6) Embryology Vision - Cornea Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Vision_-_Cornea_Development
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