|Student Information (expand to read)|
Please leave this template on top of your student page as I will add your assessment items here.
Beginning your online work - Working Online in this course
|Lab 1 Assessment - Researching a Topic|
|In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
|Lab 2 Assessment - Uploading an Image|
OK you are now in a group
Initially the topic can be as specific or as broad as you want.
Chicken embryo E-cad and P-cad gastrulation
|Lab 4 Assessment - GIT Quiz|
Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz.
An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer.
|Lab 5 Assessment - Course Review|
|Complete the course review questionnaire and add the fact you have completed to your student page.|
|Lab 6 Assessment - Cleft Lip and Palate|
|Lab 7 Assessment - Muscular Dystrophy|
|Lab 8 Assessment - Quiz|
|A brief quiz was held in the practical class on urogenital development.|
|Lab 9 Assessment - Peer Assessment|
|Lab 10 Assessment - Stem Cells|
|As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
|Lab 11 Assessment - Heart Development|
|Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.
Lab 1 Assessment
To do 5 August, due 12 August 2016
Review of a publication on human fertilisation
Write a short summary of the papers main findings
During development, all vertebrate embryos pass through the somite stage, which is defined as any developmental stage between the formation of the first and last pairs of somites in embryos (Gilbert, 2003; Mu€ller and O’Rahilly, 2003). The somite stages can vary and is not very accurate, but correspond to CS9-CS13 and occur approximately during the third and fourth weeks after fertilization of the ovum.
This study uses 37 human embryos (already fertilized) that were obtained when pregnancy was terminated during the first trimester due to socioecomomic reasons and form part of the Kyoto Collection in Japan. These embryos are classified following the Carnegie Stage (CS) 11-CS13 which is approximately 28-33 days after fertilization. These embryos were selected due to their good conditions, they were undamaged, and then were measured and examined using the criteria provided by O’Rahilly and Mueller (1987).
The embryos were then subjected to histological serial sectioning. The historical sections were scanned digitally and the morphology and the following primordia were histologically observed: the epithelium and mesenchyme of thyroid, the epithelium around the respiratory primordium region, omental bursa, ventral pancreas, and liver parenchyma. The morphology that was observed in the 2D histological slides was reconstructed in 3D. With the 3D reconstructions, the authors were able to create a precise timeline of the differentiation events that occur during this developmental time and provided key insights into these developmental processes. Using 3D reconstructions the authors were also able to observe the precise mechanisms involved during the digestive tract development during the particular somite stages. For example with the digestive tract and derived primordial, the authors were able to observe the morphology and position of the tract within the body and construct a precise time line during which development occurs. This differs from previous morphometrical studies (e.g. O’Rahilly and Mu€ller, 1984b; Otani et al., 2008) which showed that the size and proportion of the digestive tract and organ primordial varied considerably among embryos at the same stage.