Difference between revisions of "Placenta Development"

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Nutrition is derived from about 100–150 maternal uterine spiral arteries located in the basal plate.
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Nutrition is derived from about 100–150 maternal uterine spiral arteries located in the basal plate and the human term placenta is about 9 cm in diameter.
 
   
 
   
  
  
 
{{Placenta Links}} | [[ASA_Meeting_2013_-_Placenta|2013 Meeting Presentation]]
 
{{Placenta Links}} | [[ASA_Meeting_2013_-_Placenta|2013 Meeting Presentation]]
 
{{Historic Placenta}}
 
  
 
==Some Recent Findings==
 
==Some Recent Findings==
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! More recent papers  
 
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}
 
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The presence of these three differing types of placenta have also been used to describe the pattern mammalian evolution.
 
The presence of these three differing types of placenta have also been used to describe the pattern mammalian evolution.
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{{Mouse Rat Pig table}}
  
 
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* '''Neuroblastoma''' - a fetal malignancy that leads to an enlarged placenta, with tumor cells in the fetal circulation and rarely in the chorionic villi.
 
* '''Neuroblastoma''' - a fetal malignancy that leads to an enlarged placenta, with tumor cells in the fetal circulation and rarely in the chorionic villi.
 
* '''Thrombophilias''' - (protein C or S deficiency, factor V Leiden, sickle cell disease, antiphospholipid antibody) can generate an increased fibrin/fibrinoid deposition in the maternal or intervillous space, this can trap and kill villi.
 
* '''Thrombophilias''' - (protein C or S deficiency, factor V Leiden, sickle cell disease, antiphospholipid antibody) can generate an increased fibrin/fibrinoid deposition in the maternal or intervillous space, this can trap and kill villi.
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[[File:Kurt Benirschke.jpg|thumb|150px|Dr Kurt Benirschke]]
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==Comparative Placentation==
  
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The [http://placentation.ucsd.edu/homefs.html Comparative Placentation] website has been available online for many years providing valuable information about placentation in a wide range of species. The site was developed by Dr Kurt Benirschke, a longstanding expert in the field.<ref name="PMID9579593"><pubmed>9579593</pubmed></ref><ref name="PMID12068178"><pubmed>12068178</pubmed></ref> Dr Kurt Benirschke retired in 1994 and continued to develop and maintain the website (that is still available) until 2012, but it has not been updated since that time.
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:'''Links:''' [http://placentation.ucsd.edu/homefs.html homepage] | [http://placentation.ucsd.edu/homefs.html index] | [http://placentation.ucsd.edu/homefs.html glossary]
 
==References==
 
==References==
 
<references/>
 
<references/>
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===Articles===
 
===Articles===
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<pubmed>20933281</pubmed>
 
<pubmed>9518951</pubmed>
 
<pubmed>9518951</pubmed>
  
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===Historic===
 
===Historic===
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{{Historic Disclaimer}}
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<gallery>
 
<gallery>
File:Gray0502.jpg|Fetal circulation overview
 
 
File:Spiegel1626_table07.jpg|Placenta and Fetus
 
File:Spiegel1626_table07.jpg|Placenta and Fetus
 
File:Spiegel1626_table05fig1.jpg|Placenta Fetal Side
 
File:Spiegel1626_table05fig1.jpg|Placenta Fetal Side
 
File:Spiegel1626_table05fig2.jpg|Placenta Maternal Side
 
File:Spiegel1626_table05fig2.jpg|Placenta Maternal Side
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</gallery>
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<gallery>
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File:Keith1902_fig189.jpg|Keith 1902 Fig. 189. Diagram of the Remnants of the Umbilical Vein in the Adult
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! Gray 1918 &nbsp;
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<gallery>
 
File:Gray0031.jpg|Historic drawing of early implantation (stage 8-9)
 
File:Gray0031.jpg|Historic drawing of early implantation (stage 8-9)
 
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File:Gray0039.jpg
 
File:Gray0039.jpg
File:Keith1902_fig189.jpg|Keith 1902 Fig. 189. Diagram of the Remnants of the Umbilical Vein in the Adult
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File:Gray0502.jpg|Fetal circulation overview
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==Terms==
 
==Terms==
* '''allantois''' - An [[E#extraembryonic_membrane|extraembryonic membrane]], [[E#endoderm|endoderm]] in origin extension from the early hindgut, then cloaca into the connecting stalk of [[P#placenta|placental]] animals, connected to the superior end of developing bladder. In reptiles and birds, acts as a reservoir for wastes and mediates gas exchange. In mammals is associated/incorporated with connecting stalk/placental cord fetal-maternal interface.
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{{Placenta terms}}
* '''anastomosis''' - Term used to describe the connection between two tubes. Applied to describe the connection between peripheral blood vessels without an intervening capillary bed.
 
* '''angiogenesis''' - Term describing the development of new vessels from already existing vessels, this process is secondary to vasculogenesis which is the initial formation of first blood vessels by differentiation of pluripotent mesenchymal cells (extraembryonic mesoderm).
 
 
 
* '''chorioamnionitis''' - (CA) An intraamniotic puerperal infection described as having 3 forms: histologic, clinical (clinical chorioamnionitis, IAI), and subclinical. Intraamniotic infection is a common (2-4%) event in labor and the systemic inflammatory response can also lead to preterm birth and neonatal complications.
 
* '''chorion''' - The [[E#extraembryonic_membrane|extraembryonic membrane]] generated from [[T#trophoblast|trophoblast]] and extraembryonic mesoderm that forms [[P#placenta|placenta]]. chorion and [[A#amnion|amnion]] are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange.
 
* '''chorionic cavity''' - The fluid-filled [[E#extraembryonic_coelom|extraembryonic coelom]] (cavity) formed initially from [[T#trophoblast|trophoblast]] and extraembryonic mesoderm that forms [[P#placenta|placenta]]. chorion and [[A#amnion|amnion]] are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange. In humans, this cavity is lost during week 8 when the [[A#amniotic cavity|amniotic cavity]] expands and fuses with the chorion.
 
* '''chorion frondosum''' - (''frondosum'' = leafy) The chorion found on [[C#conceptus|conceptus]] oriented towards maternal blood supply where the majority of villi form and proliferate, will contribute the fetal component of the future [[P#placenta|placenta]].
 
* '''chorion laeve''' - (''laeve'' = smooth) The smooth chorion found on [[C#conceptus|conceptus]] away from maternal blood supply (towards uterine epithelium and cavity) with very few villi present.
 
* '''chorionic gonadotropin''' - (CG, human chorionic gonadotropin, hCG) A hormone see [[H#human chorionic gonadotropin|human chorionic gonadotropin]].
 
* '''chorionic somatomammotropin''' - (CSH, human lactogen) A hormone synthesized within the [[P#placenta|placenta]] by syncytiotrophoblast cells. This protein hormone (190 amino acid) has a structure is similar to pituitary growth hormone.
 
* '''chorionic villus sampling''' - (CVS) The taking a biopsy of the [[P#placenta|placenta]], usually at the end of the second month of pregnancy, to test the [[F#fetus|fetus]] for genetic abnormalities.
 
* '''coelocentesis''' - A sampling of extracoelomic fluid usually for an early prenatal diagnostic technique.
 
* '''cord blood''' - (human umbilical cord blood, HUCB) A term used to describe blood collected from the [[P#placenta|placenta]] usually after birth. Has been identified as a source of stem cells with potential therapeutic uses and is stored in Cord Blood Banks throughout the world.
 
* '''cord knotting''' Term describing umbilical or placental cord knotting. This occurs in about 1%  prevents the passage of placental blood, pseudoknots also occur usually with no effect.
 
* '''cord presentation''' - A term used to describe at birth the presence of the [[U#umbilical_cord|umbilical cord]] between the fetal presenting part and the [[C#cervix|cervix]], with or without membrane rupture.
 
* '''cord prolapse''' - A term used to describe at birth the descent of the umbilical cord through the cervix alongside (occult) or past (overt) the presenting part in the presence of ruptured membranes (incidence of 0.1% to 0.6%). 
 
* '''cotyledon''' - (Greek, ''kotyle'' = a deep cup) In the embryos of seed plants, the "seed leaves," in which nutrients are stored for use after germination. In placental animals, the term is also to describe the leaf-like structure of the [[P#placenta|placenta]] surface.
 
* '''cytotrophoblast''' - The "cellular" [[T#trophoblast|trophoblast]] layer surrounding (forming a "shell") the early implanting [[C#conceptus|conceptus]]. Beginning at uterine adplantation, proliferation and fusion of these cells is thought to form a second outer [[T#trophoblast|trophoblast]] layer, the [[S#syncytiotrophoblast|syncytiotrophoblast]]. The cytotrophoblast layer contributes to formation of the placental villi, the functional component of the fetal [[P#placenta|placenta]].
 
 
 
* '''decidua basalis''' - The term given to the uterine endometrium at the site of implantation where signaling transforms the uterine stromal cells (fibroblast-like) into decidual cells. This forms the maternal component of the [[P#placenta|placenta]], the decidualization process gradually spreads through the remainder of the [[U#uterus|uterus]], forming the decidua parietalis.
 
* '''decidua basalis reaction''' - Term describing the maternal endometrial changes that occur initially at the site of, and following, blastocyst implantation. Seen as a deposition of glycogen, fibrin and proliferation of blood vessels. See also [[D#decidualization|decidualization]].
 
* '''decidua capsularis''' - The term given to the uterine endometrium which has been converted to decidua surrounding the conceptus on the smooth chorion side.
 
* '''decidua parietalis''' - The term given to the remainder of the uterine [[E#endometrium|endometrium]], away from the site of [[I#implantation|implantation]], that gradually becomes comverted to [[D#decidua|decidua]].
 
* '''decidual cell''' - The uterine stromal cells (fibroblast-like) that differentiate in response to both steroid hormones (progesterone) and embryonic signals. These cells then alter uterine environment to support further embryonic development as well as producing cytokines related to prolactin (PRL) and have an innate immune function.
 
* '''decidualization''' - (decidualisation) The process by which uterine stromal cells differentiate in response to both steroid hormones and embryonic signals into large epitheliod decidual cells. This process is essential for the progress of implantation and establishing fetal-maternal communication.
 
 
 
* '''fetal erythroblastosis''' - (Haemolytic Disease of the Newborn) A clinical term describing an immune response between fetal and maternal blood groups; from fetus Rh+ / maternal Rh-. The leakage of blood from fetus, particularly at birth, causes maternal anti-Rh antibodies, which is then dangerous for a 2nd or future pregnancies.
 
* '''fibrinoid layer''' - ([[N#Nitabuch's layer|Nitabuch's layer]]) A layer formed at maternal/fetal interface during [[P#placenta|placentation]] and is thought to act to prevent excessively deep conceptus implantation. Fibrin-type fibrinoid (maternal blood-clot product) and matrix-type fibrinoid (secreted by invasive extravillous [[T#trophoblast|trophoblast]] cells).
 
* '''floating chorionic villi''' - Term used to describe the placental microanatomy structure of [[C#chorionic villi|chorionic villi]] that '''are not''' attached to the maternal decidua and float in the maternal blood-filled space (lacunae). Structurally the same as [[A#anchoring chorionic villi|anchoring chorionic villi]] conceptus side that are attached to the maternal decidua.These villi go through the same stages of development: [[P#primary villi|primary]], [[S#secondary villi|secondary]] and [[T#tertiary villi|tertiary]] villi.
 
 
 
* '''hemotrophic nutrition''' - Term used to describe in late [[P#placenta|placenta]] development the transfer of blood-borne nutrition from maternal to [[E#embryo|embryo]]/[[F#fetus|fetus]] compared to early [[H#histiotrophic_nutrition|histiotrophic nutrition]].
 
* '''histiotrophic nutrition''' - Term used to describe in early [[P#placenta|placenta]] development the intital transfer of nutrition from maternal to [[E#embryo|embryo]] (histiotrophic nutrition) compared to later blood-borne nutrition ([[H#hemotrophic_nutrition|hemotrophic nutrition]]). Histotroph is the nutritional material accumulated in spaces between the maternal and fetal tissues, derived from the maternal endometrium and the uterine glands. This nutritional material is absorbed by phagocytosis initially by blastocyst trophectoderm and then by [[T#trophoblast|trophoblast]] of the [[P#placenta|placenta]]. in later placental development nutrition is by the exchange of blood-borne materials between the maternal and fetal circulations, hemotrophic nutrition.
 
* '''Hofbauer cells''' - Cells found within [[P#placenta|placental]] villi connective tissue. Have a role as macrophages of mesenchymal origin with potentially additional functions (remodeling, vasculogenesis, regulation of stromal water content).
 
* '''hydatiform mole''' - A uterine tumour with "grape-like" [[P#placenta|placenta]] appearance without enclosed [[E#embryo|embryo]] formation, arises mainly from a haploid sperm fertilizing an egg without a female pronucleus. It is one form of [[G#gestational trophoblastic disease|gestational trophoblastic disease]] (GTD), a number of abnormalities including [[H#hydatiform mole|hydatiform mole]], invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT).
 
* '''Langhans layer''' - cytotrophoblast cell layer.
 
* '''Nitabuch's layer''' - ([[F#fibrinoid layer|fibrinoid layer]]) The layer formed at maternal/fetal interface during [[P#placenta|placentation]] and is thought to act to prevent excessively deep conceptus [[I#implantation|implantation]]. Fibrin-type fibrinoid (maternal blood-clot product) and matrix-type fibrinoid (secreted by invasive extravillous [[T#trophoblast|trophoblast]] cells).
 
* '''persistent right umbilical vein''' - (PRUV) A placental cord abnormality associated with fetal abnormalities and poor neonatal prognosis. The estimated incidence of persistent right umbilical vein in a low-risk population is 1 : 526. [http://www.ncbi.nlm.nih.gov/pubmed/12047534 PMID: 12047534]
 
* '''placenta''' - (Greek, ''plakuos'' = flat cake) The developmental organ formed from maternal and fetal contributions in animals with placental development. In human, the placenta at term is a discoid shape "flat cake" shape; 20 cm diameter, 3 cm thick and weighs 500-600 gm. Placenta are classified by the number of layers between maternal and fetal blood (Haemochorial, Endotheliochorial and Epitheliochorial) and shape (Discoid, Zonary, Cotyledenary and  Diffuse). The placenta has many different functions including metabolism, transport and endocrine.
 
* '''placenta accreta''' - The abnormal placental adherence, either in whole or in part of the [[P#placenta|placenta]] with absence of [[D#decidua basalis|decidua basalis]], leading to retention as an after-birth to the underlying uterine wall. The incidence of [[P#placenta|placenta]] accreta also significantly increases in women with previous cesarean section compared to those without a prior surgical delivery.
 
* '''placental arteries''' - ([[U#umbilical arteries|umbilical arteries]]) In placental animals, the blood vessels which develop within the placental cord carrying relatively deoxygenated blood from the [[E#embryo|embryo]]/[[F#fetus|fetus]] to the [[P#placenta|placenta]]. In humans, there are two placental arteries continuous with the paired internal iliac arteries (hypogastric arteries) arising off the [[D#dorsal aorta|dorsal aortas]]. At birth this vessel regresses and form the remnant [[M#medial umbilical ligament|medial umbilical ligament]].
 
* '''placental cord''' - ([[U#umbilical cord|umbilical cord]]) The placental cord is the structure connecting the embryo/fetus to the [[P#placenta|placenta]]. It is initially extra-embryonic mesoderm forming the connecting stalk within which the placental blood vessels (arteries and veins) form. In human placental cords the placental blood vessels are initially paired, later in development only a single placental vein remains with a pair of placental arteries. This structure also contains the [[A#allantois|allantois]], an extension from the hindgut cloaca then urogenital sinus. Blood collected from the placental cord following delivery is a source of cord blood stem cells.)
 
* '''placental diameter''' - is measured in the transverse section by calculating the maximum dimensions of the chorionic surface.
 
 
 
* '''placental growth factor''' - ([[#PlGF|PlGF]]) A growth factor of the vascular endothelial growth factor (VEGF) family, released from the placental [[T#trophoblast|trophoblast]] cells and other sources that stimulates blood vessel growth.
 
* '''placental malaria''' - The malarial infection of the [[P#placenta|placenta]] by sequestration of the infected red blood cells. This condition can be common in regions where malaria is endemic with women carrying their first pregnancy ([[P#primigravida|primigravida]]).
 
* '''placental membranes''' - [[C#chorionic membrane|chorionic membrane]] [[A#amniotic membrane]]) General term to describe the membrane bound extra-embryonic fluid-filled cavities surrounding the embryo then fetus. In humans the [[A#amniotic membrane]] and [[C#chorionic membrane|chorionic membrane]] fuse.
 
* '''placental thickness''' - is measured at its mid-portion from the chorionic plate to the basilar plate, on a longitudinal plane (less than 4 cm at term). Excludes any abnormalities (fibroids, myometrial contractions, or venous lakes). The placental thickness approximates in millimeters to the weeks of gestation.
 
* '''placental vein''' - ([[U#umbilical vein|umbilical vein]]) In placental animals, the blood vessels which develop within the placental cord carrying relatively oxygenated blood from the [[P#placenta|placenta]] to the [[E#embryo|embryo]]/[[F#fetus|fetus]]. In humans, there are initially two placental veins which fuse to form a single vein. The resence of paired veins in the placental cord can be indicative of developmental abnormalities.
 
* '''placentophagia''' - Term used to descrbe the maternal ingestion of afterbirth materials (placental membranes and amniotic fluid) that can occur following mammalian parturition (birth).
 
* '''primary villi''' - (primary chorionic villi) Term describing the earliest stage of embryonic placenta development. In humans, the conceptus during week 2 this first stage of [[C#chorion|chorionic]] villi development consists of only the [[T#trophoblast|trophoblastic shell cells]] ([[S#syncitiotrophoblast|syncitiotrophoblasts]] and [[C#cytotrophoblast|cytotrophoblasts]]) forming finger-like extensions into maternal decidua.  Initially these finger-like projections cover the entire surface of chorionic sac and later become restricted to the placental surface. The villi stages are ongoing as the placenta continues to grow through both the embryonic and fetal development. '''Placental villi stages:''' [[P#primary villi|primary villi]] - [[S#secondary villi|secondary villi]] - [[T#tertiary villi|tertiary villi]]
 
 
 
* '''secondary villi''' - (secondary chorionic villi) Term describing the second stage of embryonic placenta development. In humans, the conceptus during week 3 onward this stage of [[C#chorion|chorionic]] villi development consists of the [[T#trophoblast|trophoblastic shell cells]] ([[S#syncitiotrophoblast|syncitiotrophoblasts]] and [[C#cytotrophoblast|cytotrophoblasts]]) filled with extraembryonic mesoderm forming finger-like extensions into maternal decidua. Initially these finger-like projections cover the entire surface of chorionic sac and later become restricted to the placental surface. The villi stages are ongoing as the placenta continues to grow through both the embryonic and fetal development. '''Placental villi stages:''' [[P#primary villi|primary villi]] - [[S#secondary villi|secondary villi]] - [[T#tertiary villi|tertiary villi]]
 
* '''syncytiotrophoblast''' - A multinucleated cell currently thought to form by the fusion of another [[T#trophoblast|trophoblast]] cell the [[C#cytotrophoblast|cytotrophoblasts]], within the [[T#trophoblast|trophoblast]] layer (shell) of the implanting [[C#conceptus|conceptus]]. In early development, these cells mediate implantation of the conceptus into the uterine wall and secrete the hormone ([[C#human_chorionic_gonadotrophin|human Chorionic Gonadotrophin]], hCG) responsible for feedback maintainance of the corpus luteum (in maternal [[O#ovary|ovary]]) and therefore maintaining early pregnancy.
 
 
 
* '''tertiary  villi''' - (tertiary  chorionic villi) Term describing the final stage of embryonic placenta development. In humans, the conceptus after week 3 the [[C#chorion|chorionic]] [[S#secondary villi|secondary villi]] now develop placental blood vessels within the core [[E#extraembryonic mesoderm|extraembryonic mesoderm]]. The villi form finger-like extensions that are either [[A#anchoring chorionic villi|anchoring chorionic villi]] attached to the maternal decidua or [[F#floating chorionic villi|floating chorionic villi]] in maternal lacunae. The villi stages are ongoing as the placenta continues to grow through both the embryonic and fetal development. '''Placental villi stages:''' [[P#primary villi|primary villi]] - [[S#secondary villi|secondary villi]] - [[T#tertiary villi|tertiary villi]]
 
 
 
* '''villi''' - Plural of villus, which is a thin projection from a surface. The term in development is used to describe the individual functional units together of the fetal [[P#placenta|placenta]].
 
 
 
* '''Wharton's jelly''' - [[P#placental cord|Placental cord]] (umbilical cord) gelatinous connective tissue composed of myofibroblast-like stromal cells, collagen fibers, and proteoglycans. Increases in volume (myxomatous, connective tissue embedded in mucus) at parturition (birth) to assist closure of placental blood vessels. Matrix cells from Wharton's jelly have recently been identified as a potential source of [[M#mesenchymal stem cell|mesenchymal stem cells]] (MSC), also called mesenchymal stromal cell. This placental cord substance is named after Thomas Wharton (1614-1673) an English physician and anatomist who first described this placental tissue.
 
  
 
==External Links==
 
==External Links==
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* '''Comparative Placentation''' [http://placentation.ucsd.edu/homefs.html homepage] | [http://placentation.ucsd.edu/homefs.html index] | [http://placentation.ucsd.edu/homefs.html glossary]
 
* '''Comparative Placentation''' [http://placentation.ucsd.edu/homefs.html homepage] | [http://placentation.ucsd.edu/homefs.html index] | [http://placentation.ucsd.edu/homefs.html glossary]
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* '''The Human Placenta Project''' - a collaborative research effort, launched by the NICHD to understand the role of the placenta in health and disease.[https://www.nichd.nih.gov/research/HPP/Pages/default.aspx Human Placenta Project] | [http://youtu.be/MGhGkMM9-B0 Video]
 
* '''International Federation of Placenta Associations''' [http://www.ifpafederation.org/meetings/IFPA_meetings.htm IFPA Meetings] | [http://tsforum.event123.no/IFPA/EPG2011 2011 IFPA Meeting, Geilo, Norway]
 
* '''International Federation of Placenta Associations''' [http://www.ifpafederation.org/meetings/IFPA_meetings.htm IFPA Meetings] | [http://tsforum.event123.no/IFPA/EPG2011 2011 IFPA Meeting, Geilo, Norway]
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{{Systems}}
 
{{Systems}}

Latest revision as of 18:17, 30 May 2017

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Introduction

Human Placental Membranes
Placenta anchoring villi and Maternal decidua

The placenta (Greek, plakuos = flat cake) named on the basis of this organs gross anatomical appearance. The placenta a mateno-fetal organ which begins developing at implantation of the blastocyst and is delivered with the fetus at birth. During that 9 month period it provides nutrition, gas exchange, waste removal, a source of hematopoietic stem cells, endocrine and immune support for the developing fetus.


There are essentially 3 separate aortic/venous circulatory systems: umbilical, systemic and vitelline. The umbilical system is lost at birth, the vitelline contributes to the portal system and the systemic (embryonic) is extensively remodelled to form the mature cardiovascular system.


Nutrition is derived from about 100–150 maternal uterine spiral arteries located in the basal plate and the human term placenta is about 9 cm in diameter.


Placenta Links: Introduction | Lecture - Placenta | Lecture Movie | Practical - Placenta | Implantation | Villi Development | Trophoblast | Maternal Decidua | Endocrine | Cord | Membranes | Abnormalities | Stage 13 | Stage 22 | Histology | Vascular Beds | Blood Vessel Development | Stem Cells | 2013 Meeting Presentation | Placenta Terms | Category:Placenta
Historic Embryology - Placenta 
1883 Embryonic Membranes | 1907 Development Atlas | 1909 | 1910 Textbook | 1917 Textbook | 1921 Textbook | 1921 Foetal Membranes |1921 human | 1921 Pig implantation | 1922 Single placental artery | 1923 Placenta Review | 1939 umbilical cord | 1943 human and monkey | 1944 chorionic villus and decidua parietalis | 1946 placenta ageing | 1960 monkey | 1972 Placental circulation | Historic Disclaimer
| 2013 Meeting Presentation

Some Recent Findings

  • Hox genes in the allantois essential for proper extra-embryonic function in placental mammals[1]" Here, we provide evidence that this functional novelty is not exclusive to Hoxa13 but is shared with its neighboring Hoxa11 and Hoxa10 genes. We show that the extra-embryonic function of these three Hoxa genes stems from their specific expression in the allantois, an extra-embryonic hallmark of amniote vertebrates. Interestingly, Hoxa10-13 expression in the allantois is conserved in chick embryos, which are non-placental amniotes, suggesting that the extra-embryonic recruitment of Hoxa10, Hoxa11 and Hoxa13 most likely arose in amniotes, i.e. prior to the emergence of placental mammals."
  • A transient placental source of serotonin for the fetal forebrain[2] "Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental processes through maternal-fetal interactions that have long-term mental health implications. It is thought that beyond fetal 5-HT neurons there are significant maternal contributions to fetal 5-HT during pregnancy but this has not been tested empirically. ...We uncovered a placental 5-HT synthetic pathway from a maternal tryptophan precursor in both mice and humans. This study reveals a new, direct role for placental metabolic pathways in modulating fetal brain development and indicates that maternal-placental-fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes."
  • Comparative systems biology of human and mouse[3]"We collected protein and mRNA expression data through shot-gun proteomics and microarray expression analysis of the highly vascular exchange region, microdissected from the human and mouse near-term placenta. Over 7000 ortholog genes were detected with 70% co-expressed in both species. Close to 90% agreement was found between our human proteomic results and 1649 genes assayed by immunohistochemistry for expression in the human placenta in the Human Protein Atlas. Interestingly, over 80% of genes known to cause placental phenotypes in mouse are co-expressed in human."
More recent papers  
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A Multhaup, B Huppertz, C Göhner, M Böhringer, M Mai, U Markert, E Schleußner, T Groten N-cadherin knockdown leads to disruption of trophoblastic and endothelial cell interaction in a 3D cell culture model - New insights in trophoblast invasion failure. Cell Adh Migr: 2017;1-12 PubMed 29231798

Nese Colcimen, Gülay Bulut, Ozlem Ergul Erkec, Murat Cetin Ragbetli Investigation of role of vascular endothelial growth factor, Annexin A5 and Apelin by immunohistochemistry method in placenta of preeclampsia patients. Cell. Mol. Biol. (Noisy-le-grand): 2017, 63(11);42-45 PubMed 29208172

R G Ahmed Gestational 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction. Life Sci.: 2017; PubMed 29175438

Ivo Brosens, Marisa Benagiano, Patrick Puttemans, Mario M D'Elios, Giuseppe Benagiano The placental bed vascular pathology revisited: a risk indicator for cardiovascular disease. J. Matern. Fetal. Neonatal. Med.: 2017;1-161 PubMed 29172831

Martina Hutabarat, Noroyono Wibowo, Berthold Huppertz The trophoblast survival capacity in preeclampsia. PLoS ONE: 2017, 12(11);e0186909 PubMed 29107968

Reading

Spiegel and Casseri: De formato foetu liber singularis (Dedication dated 1626).
  • Human Embryology (2nd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Vasculature
  • The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 14: p304-349
  • Before we Are Born (5th ed.) Moore and Persaud Chapter 12; p241-254
  • Essentials of Human Embryology Larson Chapter 7 p97-122 Heart, Chapter 8 p123-146 Vasculature
  • Human Embryology Fitzgerald and Fitzgerald Chapter 13-17: p77-111

Placental Classification

Haemomonochorial human placenta villi (EM) showing syncitiotrophoblast cells.[4]

Classification of placenta is on the basis of histological (microscopic) structural organization and layers between fetal and maternal circulation.

Three main groups:

  1. Haemochorial - placenta where the chorion comes in direct contact with maternal blood (human).
  2. Endotheliochorial - maternal endometrial blood vessels are bare to their endothelium and these comes in contact with the chorion (dogs, cats).
  3. Epitheliochorial - maternal epithelium of the uterus comes in contact with the chorion, considered as primitive (pigs, cows).

The presence of these three differing types of placenta have also been used to describe the pattern mammalian evolution.


Postnatal Animal Models Mouse Rat Pig
Pregnancy period (days) 18 – 21 21 – 23 110 – 118
Placenta type Discoidal, decidual
hemoendothelial choroidea
Discoidal, decidual
hemoendothelial choroidea
Epitheliochorial
Litter size 6 – 12 6 – 15 11 – 16
Birth weight (g) 0.5 – 1.5 3 – 5 900 – 1600
Weaning weight male/female (g) 18 – 25/16 – 25 55 – 90/45 – 80 6000 – 8000
Suckling period (days) 21–28 21 28–49
Solid diet beginning (days) 10 12 12 – 15
Puberty male/female (week) 4 – 6/5 6/6 – 8 20 – 28
Life expectancy (years) 1 - 2 2 - 3 14 – 18
PMID 13207763
Male Placenta?
Mark Hill.jpg
Well not exactly, but close. In vertebra and in placental mammals embryonic development is associated with the mother (maternal). The exception to this rule occurs in seahorses (syngnathidae) where the male has a "uterus", a special pouch (brood pouch), where deposited eggs embed in depressions of the pouch interior lining. This pouch also has "placental" functions serving as aeration, protection, osmoregulation and nutrition for the egg development. (More? PMID 23213429)

Placenta term anatomy 01.jpg

Placenta MRI 01.jpg

Placenta MRI (37 weeks)[5] Placenta located at the upper segment of uterus.


Gray0039.jpg

Placental Villi Blood Vessels

Implanting Conceptus[6]
Fetal circulation overview

Some of the following data is from a histological study of human placental villi.[7]

  • macrophage-like cells first cells to differentiate at day 21 (post-conception) from mesenchymal precursors.
  • haemangioblastic cell cords (angiogenic cell cords, ACC) at day 21 (post-conception) also from mesenchymal cells, are the precursors of the capillary endothelium and haematopoietic stem cells
  • pericytes form later and are a third cell population derived from the mesenchymal cells
  • first main vascular patterns grow towards the longitudinal axis of the developing villi
  • capillary basal lamina cannot be detected earlier than in the third trimester
  • third trimester - fetal villous angiogenesis occurs by proliferation of the existing endothelium and pericytes rather than through haemangioblastic cells.

Human Villi Timeline

The placental vill development data below is based upon a recent immunochemistry confocal laser scanning microscope (CLSM) study.[8]

Note that the paper uses clinical gestational age (GA) from last menstrual period (LMP) and has been corrected for post-conception (fertilization) age, approximately 14 days later.

Fertilization Age

(weeks)

Gestational Age

(weeks)

Vessel Lumen Diameter

(range in microns)

Features
3 to 4 5 and 6 10 - 15
  • a complex network of cords and vessels with redundant connections
  • network comprises mainly cords, already connected together
  • vessels and cords are connected to each other without any interruptions
  • chorionic villus dominated by this network of vascular elements
  • vessels and cords are located centrally as well as peripherally and as a consequence contact the overlying trophoblastic layer
5 to 6 7 and 8 10 - 26
  • villi dominated by capillary network of vessels and cords
  • capillary network contains more vessels than cords
  • chorionic villus tip - regular small branched off (mesenchymal) chorionic villi are present containing CD31 positive cells
7 to 8 9 and 10 60 - 75 two central vessels

26 - 34 capillary network

  • villi have two large centrally located vessels
  • surrounded by and connected to a peripheral capillary network
  • capillary network contains vessels with a lumen in tight contact with overlying trophoblastic layer
  • villous projections also contain blind ending capillary sprouts
9 to 10 11 and 12 70 - 90 two central vessels

26 - 34 capillary network

  • immature intermediate villi characterized by two large vessels surrounded by a capillary network
  • capillary network has few cords
  • blind ending capillary sprouts off the capillary network
Term Terminal villi
  • have an extensive surface area >10 m2
  • small calibre (40 – 100 µm)



CD31 - (PECAM-1, Platelet Endothelial Cell Adhesion Molecule) is a cluster of differentiation molecule found on endothelial and other blood cells.

Trophoblast Cells

Following implantation the initial trophoblast cells can differentiate into 2 pathways:

  1. Extravillous - cytotrophoblastic cells proliferate and differentiate into an invasive phenotype that invade (interstitial trophoblast) the maternal decidual stroma and the spiral arteries (endovascular trophoblast) of the myometrium.
  2. Villous - cytotrophoblastic cells proliferate and fuse to form the multi-nucleated syncytiotrophoblast cells that form the outer surface of the fetal placental villi.


Maternal Blood Flow

Uterine Vascular
Uterine Arteries

Maternal blood pressure normally decreases or remains unchanged during pregnancy while both cardiac output and vascular volume are increased. Uterine blood flow changes are principally due to a decrease in uterine vascular resistance. There is also an associated structural enlargement of both the uterine arterial and venous trees, reduced vascular tone (vasodilation) and placenta development.

Uteroplacental blood flow (UPBF) was historically measured by a number of different mathematical calculations and probe methods, currently the method involves transvaginal doppler ultrasonography.

In human singleton pregnancies, uteroplacental blood flow (UPBF) begins at 20–50 ml/min and increases (linearly) to 450–800 ml/min, with twin pregnancy values in excess of 1 l/min.[9]


Uterine Artery Diameter

The following data is from a study of 18 pregnant women using ultrasound and doppler analysis of the uterine artery.[10]

  • GA week 21 doubled (from 1.4 to 2.8 mm).
  • GA week 21 to 30 remained constant (2.9mm).
  • GA week 30 to 36 increased (to 3.4 mm).

Uterine artery mean flow velocity also increased nearly eight times from non-pregnant (8.4 cm/second) to GA week 36 (61.4 cm/second).

Arcuate and Radial Arteries

These branches from the paired uterine arteries also remodel enlarging in lumen diameter between 25 to 220% with either no change or an increase in wall thickness. Arcuate arteries also elongate either by longitudinal growth or by the progressive straightening of these coiled vessels.


Links: Ultrasound | Cardiovascular System Development

Term Placenta Measurements

Human term placental volumes sorted by size (from table).

There are a variety of diagnostic and morphological measurements that can be made of the placenta during pregnancy and at term.

Simple measurements of overall placental diameter, thickness and volume:

  • placental diameter - is measured in the transverse section by calculating the maximum dimensions of the chorionic surface.
  • placental thickness - is measured at its mid-portion from the chorionic plate to the basilar plate, on a longitudinal plane (less than 4 cm at term). Excludes any abnormalities (fibroids, myometrial contractions, or venous lakes). The placental thickness approximates in millimeters to the weeks of gestation.
  • placental volume - is measured by a range of different methods and calculations, more recently with three-dimensional ultrasound.

Detailed morphometric indices at term of placental composition, villous capillarization and the mean cross-sectional areas of peripheral villi and capillaries, data from a study sample of 15 normal placenta (mean placental volume, 652 ml). [11][12]

Variable Unit Placenta (mean, n = 15)
Intervillous space mL 213
Stem villi mL 71.4
Peripheral villi mL 326
Trophoblast mL 95.5
Stroma mL 184
Fetal capillaries mL 46.9
Non-parenchyma mL 41.5
Peripheral villi km 89.2
Fetal capillaries km 310
TS area villi µm2 3700
TS area capillary µm2 150
Capillaries mL mL-1 0.147
Length ratio km km-1 3.6

Placental Factors

As the placenta develops it becomes the source of many different factors (hormones, growth factors) and also has the ability to metabolise both maternal and fetal factors.

Placental Growth Factor

(PGF, PLGF) A growth factor of the vascular endothelial growth factor (VEGF) family, released from the placental trophoblast cells and other sources that stimulates blood vessel growth. See review.[13]


Links: OMIM601121 | Search PubMed

Insulin/insulin-like Growth Factor

  • IGF1 and IGF2 are both synthesized in the placenta and the fetus.
  • IGF1 present in syncytiotrophoblast and cytotrophoblast at all stages.
  • IGF2 not found in the syncytiotrophoblasts.
  • IGF2 expression in the villous and extravillous cytotrophoblasts in the first trimester becomes undetectable at term.

Placental Arteries and Vein

Placental cord vessels 02.jpg Placental cord vessels 01.jpg Placental cord cross-section.jpg

Placental Cord Histology


Links: Placenta - Cord | Placenta - Histology

Placental Abnormalities

Placental abnormalities
Historic model of placenta previa
Hydatidiform mole pathology

Note there is also a specific page covering the topic of placental abnormalities.


  • Placenta Accreta - abnormal adherence, with absence of decidua basalis. The incidence of placenta accreta also significantly increases in women with previous cesarean section compared to those without a prior surgical delivery.
  • Placenta Increta - occurs when the placenta attaches deep into the uterine wall and penetrates into the uterine muscle, but does not penetrate the uterine serosa. Placenta increta accounts for approximately 15-17% of all cases.
  • Placenta Percreta - placental villi penetrate myometrium and through to uterine serosa.
  • Placenta Previa - In this placenatal abnormality, the placenta overlies internal os of uterus, essentially covering the birth canal. This condition occurs in approximately 1 in 200 to 250 pregnancies. In the third trimester and at term, abnormal bleeding can require cesarian delivery and can also lead to Abruptio Placenta. Ultrasound screening programs during 1st and early 2nd trimester pregnancies now include placental localization. Diagnosis can also be made by transvaginal ultrasound.
  • Vasa Previa - (vasa praevia) placental abnormality where the fetal vessels lie within the membranes close too or crossing the inner cervical os (opening). This occurs normally in 1:2500-5000 pregnancies and leads to complications similar too those for Placenta Previa.Type II is defined as the condition where the fetal vessels are found crossing over the internal os connecting either a bilobed placenta or a succenturiate lobe with the main placental mass. Some recent evidence of successful in utero laser ablation of type II vasa previa at 22.5 weeks of gestation.
  • Abruptio Placenta - a retroplacental blood clot formation, abnormal hemorrhage prior to delivery.
  • Chronic Intervillositis - (massive chronic intervillositis, chronic histiocytic intervillositis) Rare placental abnormality and pathology defined by inflammatory placental lesions, mainly in the intervillous space (IVS), with a maternal infiltrate of mononuclear cells (monocytes, lymphocytes, histiocytes) and intervillous fibrinoid deposition.
  • Hydatidiform mole - placental tumor with no embryo development. Several forms of hydatidiform mole: partial mole, complete mole and persistent gestational trophoblastic tumor. Many of these tumours arise from a haploid sperm fertilizing an egg without a female pronucleus (the alternative form, an embryo without sperm contribution, is called parthenogenesis). The tumour has a "grape-like" placental appearance without enclosed embryo formation. Following a first molar pregnancy, there is approximately a 1% risk of a second molar pregnancy.


Links: Placenta - Abnormalities


Placental Cord Abnormalities

There are few abnormalities associated with umbilical cord development, other that abnormally short or long cords, which in most cases do not cause difficulties. In some cases though, long cords can wrap around limbs or the fetus neck, which can then restrict blood flow or lead to tissue or nerve damage, and therefore effect develoment.

  • Cord knotting - can also occur (1%) in most cases these knots have no effect, in some cases of severe knotting this can prevents the passage of placental blood.
  • Cord torsion - Rare event where even without knot formation can also affect placental blood flow, even leading to fetal demise.


Links: Placenta Cord Development | Placenta - Abnormalities | WebPath - umbilical cord knot 1 | WebPath - umbilical cord knot 2 | WebPath - Pseudoknot of umbilical cord, gross | WebPath - Torsion of umbilical cord, gross | WebPath - Torsion of umbilical cord, with fetal demise, gross

Placental Infections

Malaria (plasmodium falciparum)
  • Several infective agents may cross into the placenta from the maternal circulation, as well as enter the embry/fetal circulation. The variety of bacterial infections that can occur during pregnancy is as variable as the potential developmental effects, from virtually insignificant to a major developmental, abortive or fatal in outcome.
  • Pregnant women have an increased susceptibility to malaria infection. Malarial infection of the placenta by sequestration of the infected red blood cells leading to low birth weight and other effects. There are four types of malaria caused by the protozoan parasite Plasmodium falciparum (main), Plasmodium vivax, Plasmodium ovale, Plasmodium malariae). This condition is common in regions where malaria is endemic with women carrying their first pregnancy (primigravida).


Links: Abnormal Development - Malaria | Viral | Bacterial

Placental Pathology

  • Chronic Villitis - can occur following placental infection leading to maternal inflammation of the villous stroma, often with associated intervillositis. The inflammation can lead to disruption of blood flow and necrotic cell death.
  • Massive Chronic Intervillositis (MCI) - maternal blood-filled space is filled with CD68-positive histiocytes and an increase in fibrin, occuring more commonly in the first trimester.
  • Meconium Myonecrosis - prolonged meconium exposure leads to toxic death of myocytes of placental vessels (umbilical cord or chorionic plate).
  • Neuroblastoma - a fetal malignancy that leads to an enlarged placenta, with tumor cells in the fetal circulation and rarely in the chorionic villi.
  • Thrombophilias - (protein C or S deficiency, factor V Leiden, sickle cell disease, antiphospholipid antibody) can generate an increased fibrin/fibrinoid deposition in the maternal or intervillous space, this can trap and kill villi.
Dr Kurt Benirschke

Comparative Placentation

The Comparative Placentation website has been available online for many years providing valuable information about placentation in a wide range of species. The site was developed by Dr Kurt Benirschke, a longstanding expert in the field.[14][15] Dr Kurt Benirschke retired in 1994 and continued to develop and maintain the website (that is still available) until 2012, but it has not been updated since that time.


Links: homepage | index | glossary

References

  1. Martina Scotti, Marie Kmita Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development: 2012, 139(4);731-9 PubMed 22219351
  2. Alexandre Bonnin, Nick Goeden, Kevin Chen, Melissa L Wilson, Jennifer King, Jean C Shih, Randy D Blakely, Evan S Deneris, Pat Levitt A transient placental source of serotonin for the fetal forebrain. Nature: 2011, 472(7343);347-50 PubMed 21512572
  3. Brian Cox, Max Kotlyar, Andreas I Evangelou, Vladimir Ignatchenko, Alex Ignatchenko, Kathie Whiteley, Igor Jurisica, S Lee Adamson, Janet Rossant, Thomas Kislinger Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology. Mol. Syst. Biol.: 2009, 5;279 PubMed 19536202
  4. Anthony M Carter, Allen C Enders Comparative aspects of trophoblast development and placentation. Reprod. Biol. Endocrinol.: 2004, 2;46 PubMed 15236656 | Reprod Biol Endocrinol.
  5. Binoj Varghese, Navdeep Singh, Regi A N George, Sareena Gilvaz Magnetic resonance imaging of placenta accreta. Indian J Radiol Imaging: 2013, 23(4);379-85 PubMed 24604945 | PMC3932583 | Indian J Radiol Imaging.
  6. Joanne Hempstock, Tereza Cindrova-Davies, Eric Jauniaux, Graham J Burton Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study. Reprod. Biol. Endocrinol.: 2004, 2;58 PubMed 15265238 | Reprod. Biol. Endocrinol.
  7. R Demir, P Kaufmann, M Castellucci, T Erbengi, A Kotowski Fetal vasculogenesis and angiogenesis in human placental villi. Acta Anat (Basel): 1989, 136(3);190-203 PubMed 2481376
  8. B A M Lisman, M J B van den Hoff, K Boer, O P Bleker, K van Groningen, N Exalto The architecture of first trimester chorionic villous vascularization: a confocal laser scanning microscopical study. Hum. Reprod.: 2007, 22(8);2254-60 PubMed 17545656
  9. George Osol, Maurizio Mandala Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda): 2009, 24;58-71 PubMed 19196652
  10. S K Palmer, S Zamudio, C Coffin, S Parker, E Stamm, L G Moore Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy. Obstet Gynecol: 1992, 80(6);1000-6 PubMed 1448242
  11. T M Mayhew, H Jenkins, B Todd, V L Clifton Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Placenta: 2008, 29(4);366-73 PubMed 18328557
  12. Terry M Mayhew A stereological perspective on placental morphology in normal and complicated pregnancies. J. Anat.: 2009, 215(1);77-90 PubMed 19141109
  13. Sandro De Falco The discovery of placenta growth factor and its biological activity. Exp. Mol. Med.: 2012, 44(1);1-9 PubMed 22228176 | PDF
  14. K Benirschke Remarkable placenta. Clin Anat: 1998, 11(3);194-205 PubMed 9579593
  15. Kurt Benirschke Placentas, peccaries, and pathologists: reminiscences of Kurt Benirschke on his career: an interview with Rebecca N. Baergen. Int. J. Gynecol. Pathol.: 2002, 21(3);289-300 PubMed 12068178

Reviews

Kirsten Ferner, Andrea Mess Evolution and development of fetal membranes and placentation in amniote vertebrates. Respir Physiol Neurobiol: 2011, 178(1);39-50 PubMed 21470579

G Riquelme Review: Placental syncytiotrophoblast membranes--domains, subdomains and microdomains. Placenta: 2011, 32 Suppl 2;S196-202 PubMed 21272934

Judith E Cartwright, Rupsha Fraser, Karin Leslie, Alison E Wallace, Joanna L James Remodelling at the maternal-fetal interface: relevance to human pregnancy disorders. Reproduction: 2010, 140(6);803-13 PubMed 20837731


Wang Y, Zhao S. Vascular Biology of the Placenta. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Bookshelf NBK53247

Articles

C M Salafia, M Yampolsky, D P Misra, O Shlakhter, D Haas, B Eucker, J Thorp Placental surface shape, function, and effects of maternal and fetal vascular pathology. Placenta: 2010, 31(11);958-62 PubMed 20933281

J F Yetter Examination of the placenta. Am Fam Physician: 1998, 57(5);1045-54 PubMed 9518951


Books

  • Wang Y, Zhao S. Vascular Biology of the Placenta. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Available from: http://www.ncbi.nlm.nih.gov/books/NBK53247
  • Boyd, J.D., Hamilton, W.J. 1970. The utero-placental circulatory system. In: The Human Placenta. W Heffer and Sons Ltd, London.

Historic Textbooks and Research


Search PubMed

Search April 2010

  • Placenta Development - All (10032) Review (1896) Free Full Text (2435)
  • Placental Development - All (9103) Review (1762) Free Full Text (2219)
  • Placental Membranes - All (10083) Review (748) Free Full Text (1728)

Search Pubmed: Placenta Development | Placental Development | Placental Membranes

Additional Images

see all online Placental materials

Historic

Historic Disclaimer - information about historic embryology pages 
Mark Hill.jpg
Pages where the terms "Historic Textbook" and "Historic Embryology" appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms and interpretations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)
Gray 1918  
Gray H. Anatomy of the human body. (1918) Philadelphia: Lea & Febiger.
Bailey1921  
Bailey FR. and Miller AM. Text-Book of Embryology (1921) New York: William Wood and Co.

Terms

Placenta Terms (expand to view) 
  • after-birth - term used to describe the delivery of placenta and placental membranes following birth of the child.
  • allantois - An extraembryonic membrane, endoderm in origin extension from the early hindgut, then cloaca into the connecting stalk of placental animals, connected to the superior end of developing bladder. In reptiles and birds, acts as a reservoir for wastes and mediates gas exchange. In mammals is associated/incorporated with connecting stalk/placental cord fetal-maternal interface.
  • anastomosis - Term used to describe the connection between two tubes. Applied to describe the connection between peripheral blood vessels without an intervening capillary bed.
  • anchoring villi - (stem villi) describes the placental villi (embryonic) that attach to the decidua (maternal) tissue. The tip of the villi consists of a column of trophoblast cells attached to an epithelial plaque.
  • angioblasts form clusters or blood islands on surface of yolk sac.
  • angiogenesis - Term describing the development of new vessels from already existing vessels, this process is secondary to vasculogenesis which is the initial formation of first blood vessels by differentiation of pluripotent mesenchymal cells (extraembryonic mesoderm).
  • capsularis - portion of maternal decidua that covers the conceptus facing towards the uterine cavity.
  • chorioamnionitis - (CA) An intraamniotic puerperal infection described as having 3 forms: histologic, clinical (clinical chorioamnionitis, IAI), and subclinical. Intraamniotic infection is a common (2-4%) event in labor and the systemic inflammatory response can also lead to preterm birth and neonatal complications.
  • chorion - The extraembryonic membrane generated from trophoblast and extraembryonic mesoderm that forms placenta. chorion and amnion are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange.
  • chorionic cavity - The fluid-filled extraembryonic coelom (cavity) formed initially from trophoblast and extraembryonic mesoderm that forms placenta. chorion and amnion are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange. In humans, this cavity is lost during week 8 when the amniotic cavity expands and fuses with the chorion.
  • chorion frondosum - (frondosum = leafy) The chorion found on conceptus oriented towards maternal blood supply where the majority of villi form and proliferate, will contribute the fetal component of the future placenta.
  • chorion laeve - (laeve = smooth) The smooth chorion found on conceptus away from maternal blood supply (towards uterine epithelium and cavity) with very few villi present.
  • chorionic gonadotropin - (CG, human chorionic gonadotropin, hCG) A hormone see human chorionic gonadotropin.
  • chorionic somatomammotropin - (CSH, human lactogen) A hormone synthesized within the placenta by syncytiotrophoblast cells. This protein hormone (190 amino acid) has a structure is similar to pituitary growth hormone.
  • chorionic villus sampling - (CVS) The taking a biopsy of the placenta, usually at the end of the second month of pregnancy, to test the fetus for genetic abnormalities.
  • coelocentesis - A sampling of extracoelomic fluid usually for an early prenatal diagnostic technique.
  • connecting stalk - the original extra-embryonic mesoderm structure attaching the embryonic disc to the chorion. The placental blood vessels form within this structure.
  • cord blood - (human umbilical cord blood, HUCB) A term used to describe blood collected from the placenta usually after birth. Has been identified as a source of stem cells with potential therapeutic uses and is stored in Cord Blood Banks throughout the world.
  • cord knotting Term describing umbilical or placental cord knotting. This occurs in about 1% prevents the passage of placental blood, pseudoknots also occur usually with no effect.
  • cord presentation - A term used to describe at birth the presence of the umbilical cord between the fetal presenting part and the cervix, with or without membrane rupture.
  • cord prolapse - A term used to describe at birth the descent of the umbilical cord through the cervix alongside (occult) or past (overt) the presenting part in the presence of ruptured membranes (incidence of 0.1% to 0.6%).
  • cotyledon - (Greek, kotyle = a deep cup) In the embryos of seed plants, the "seed leaves," in which nutrients are stored for use after germination. In placental animals, the term is also to describe the leaf-like structure of the placenta surface.
  • cytotrophoblast - The "cellular" trophoblast layer surrounding (forming a "shell") the early implanting conceptus. Beginning at uterine adplantation, proliferation and fusion of these cells is thought to form a second outer trophoblast layer, the syncytiotrophoblast. The cytotrophoblast layer contributes to formation of the placental villi, the functional component of the fetal placenta.
  • decidua basalis - The term given to the uterine endometrium at the site of implantation where signaling transforms the uterine stromal cells (fibroblast-like) into decidual cells. This forms the maternal component of the placenta, the decidualization process gradually spreads through the remainder of the uterus, forming the decidua parietalis.
  • decidua basalis reaction - Term describing the maternal endometrial changes that occur initially at the site of, and following, blastocyst implantation. Seen as a deposition of glycogen, fibrin and proliferation of blood vessels. See also decidualization.
  • decidua capsularis - The term given to the uterine endometrium which has been converted to decidua surrounding the conceptus on the smooth chorion side.
  • decidua parietalis - The term given to the remainder of the uterine endometrium, away from the site of implantation, that gradually becomes comverted to decidua.
  • decidual cell - The uterine stromal cells (fibroblast-like) that differentiate in response to both steroid hormones (progesterone) and embryonic signals. These cells then alter uterine environment to support further embryonic development as well as producing cytokines related to prolactin (PRL) and have an innate immune function.
  • decidualization - (decidualisation) The process by which uterine stromal cells differentiate in response to both steroid hormones and embryonic signals into large epitheliod decidual cells. This process is essential for the progress of implantation and establishing fetal-maternal communication.
  • fetal drug addiction - occurs when drugs used maternally cross the placental barrier and can establish addiction in the unborn fetus.
  • fetal erythroblastosis - (Haemolytic Disease of the Newborn) A clinical term describing an immune response between fetal and maternal blood groups; from fetus Rh+ / maternal Rh-. The leakage of blood from fetus, particularly at birth, causes maternal anti-Rh antibodies, which is then dangerous for a 2nd or future pregnancies.
  • fibrinoid layer - (Nitabuch's layer) A layer formed at maternal/fetal interface during placentation and is thought to act to prevent excessively deep conceptus implantation. Fibrin-type fibrinoid (maternal blood-clot product) and matrix-type fibrinoid (secreted by invasive extravillous trophoblast cells).
  • floating chorionic villi - Term used to describe the placental microanatomy structure of chorionic villi that are not attached to the maternal decidua and float in the maternal blood-filled space (lacunae). Structurally the same as anchoring chorionic villi conceptus side that are attached to the maternal decidua.These villi go through the same stages of development: primary, secondary and tertiary villi.
  • hemotrophic nutrition - Term used to describe in late placenta development the transfer of blood-borne nutrition from maternal to embryo/fetuscompared to early histiotrophic nutrition.
  • histiotrophic nutrition - Term used to describe in early placenta development the intital transfer of nutrition from maternal to embryo (histiotrophic nutrition) compared to later blood-borne nutrition (hemotrophic nutrition). Histotroph is the nutritional material accumulated in spaces between the maternal and fetal tissues, derived from the maternal endometrium and the uterine glands. This nutritional material is absorbed by phagocytosis initially by blastocyst trophectoderm and then by trophoblast of the placenta. in later placental development nutrition is by the exchange of blood-borne materials between the maternal and fetal circulations, hemotrophic nutrition.
  • Hofbauer cells - Cells found within placental villi connective tissue. Have a role as macrophages of mesenchymal origin with potentially additional functions (remodeling, vasculogenesis, regulation of stromal water content).
  • Human chorionic corticotropin - (hCACTH) placental derived hormone equivilant to corticotropin (ACTH) from the pituitary.
  • Human chorionic gonadotrophin - (hCG) like leutenizing hormone, supports corpus luteum, originally secreted by trophoblast cells.
  • Human chorionic somatommotropin - (hCS, placental lactogen) hormone level increases in maternal blood through pregnancy, decreases maternal insulin sensitivity (raising maternal blood glucose levels and decreasing maternal glucose utilization) aiding fetal nutrition.
  • hydatiform mole - A uterine tumour with "grape-like" placenta appearance without enclosed embryo formation, arises mainly from a haploid sperm fertilizing an egg without a female pronucleus. It is one form of gestational trophoblastic disease(GTD), a number of abnormalities including hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT).
  • hysterectomy – clinical term for the surgical removal of the uterus.
  • Langhans layer - cytotrophoblast cell layer.
  • maternal antibodies - antibodies from the mother's immune system that are capable of crossing placental barrier. They can provide immune protection to the embryo, but may also participate in immune disease (fetal erythroblastosis).
  • maternal sinusoids - placental spaces around chorionic villi that are filled with maternal blood. This is the closest maternal/fetal exchange site.
  • Nitabuch's layer - (fibrinoid layer) The layer formed at maternal/fetal interface during placentation and is thought to act to prevent excessively deep conceptus implantation. Fibrin-type fibrinoid (maternal blood-clot product) and matrix-type fibrinoid (secreted by invasive extravillous trophoblast cells).
  • Morbidly adherent placenta (MAP) A general clinical term used to describe the different forms of abnormal placental implantation (Accreta, Increta and Percreta).
  • persistent right umbilical vein - (PRUV) A placental cord abnormality associated with fetal abnormalities and poor neonatal prognosis. The estimated incidence of persistent right umbilical vein in a low-risk population is 1 : 526. PMID: 12047534
  • placenta - (Greek, plakuos = flat cake) The developmental organ formed from maternal and fetal contributions in animals with placental development. In human, the placenta at term is a discoid shape "flat cake" shape; 20 cm diameter, 3 cm thick and weighs 500-600 gm. Placenta are classified by the number of layers between maternal and fetal blood (Haemochorial, Endotheliochorial and Epitheliochorial) and shape (Discoid, Zonary, Cotyledenary and Diffuse). The placenta has many different functions including metabolism, transport and endocrine.
  • placenta accreta - The abnormal placental adherence, either in whole or in part of the placenta with absence of decidua basalis, leading to retention as an after-birth to the underlying uterine wall. The incidence of placenta accreta also significantly increases in women with previous cesarean section compared to those without a prior surgical delivery.
  • placental arteries - (umbilical arteries) In placental animals, the blood vessels which develop within the placental cord carrying relatively deoxygenated blood from the embryo/fetus to the placenta. In humans, there are two placental arteries continuous with the paired internal iliac arteries (hypogastric arteries) arising off the dorsal aortas. At birth this vessel regresses and form the remnant medial umbilical ligament.
  • placental cord - (umbilical cord) The placental cord is the structure connecting the embryo/fetus to the placenta. It is initially extra-embryonic mesoderm forming the connecting stalk within which the placental blood vessels (arteries and veins) form. In human placental cords the placental blood vessels are initially paired, later in development only a single placental vein remains with a pair of placental arteries. This structure also contains the allantois, an extension from the hindgut cloaca then urogenital sinus. Blood collected from the placental cord following delivery is a source of cord blood stem cells.)
  • placental diameter - is measured in the transverse section by calculating the maximum dimensions of the chorionic surface.
  • placental growth factor - (PlGF) A growth factor of the vascular endothelial growth factor (VEGF) family, released from the placental trophoblast cells and other sources that stimulates blood vessel growth.
  • placental malaria - The malarial infection of the placenta by sequestration of the infected red blood cells. This condition can be common in regions where malaria is endemic with women carrying their first pregnancy (primigravida).
  • placenta membranacea - rare placental abnormality characterized by the presence of chorionic villi directly attached to and covering the fetal membranes. Placenta Membranacea
  • placenta percreta - abnormal placentation where the villi penetrate myometrium.
  • placenta previa - placenta overlies internal os of uterus, abnormal bleeding, may require cesarian delivery.
  • placental thickness - is measured at its mid-portion from the chorionic plate to the basilar plate, on a longitudinal plane (less than 4 cm at term). Excludes any abnormalities (fibroids, myometrial contractions, or venous lakes). The placental thickness approximates in millimeters to the weeks of gestation.
  • placental vein - (umbilical vein) In placental animals, the blood vessels which develop within the placental cord carrying relatively oxygenated blood from the placenta to the embryo/fetus. In humans, there are initially two placental veins which fuse to form a single vein. The resence of paired veins in the placental cord can be indicative of developmental abnormalities.
  • placentophagia - Term used to descrbe the maternal ingestion of afterbirth materials (placental membranes and amniotic fluid) that can occur following mammalian parturition (birth).
  • primary villi - (primary chorionic villi) Term describing the earliest stage of embryonic placenta development. In humans, the conceptus during week 2 this first stage of chorionic villi development consists of only the trophoblastic shell cells (syncitiotrophoblasts and cytotrophoblasts) forming finger-like extensions into maternal decidua. Initially these finger-like projections cover the entire surface of chorionic sac and later become restricted to the placental surface. The villi stages are ongoing as the placenta continues to grow through both the embryonic and fetal development.
  • pre-eclampsia - During pregnancy a combination of high blood pressure, protein in urine and fluid retention resulting in maternal sudden excessive swelling of the face, hands and feet. Eclampsia is the subsequent development of convulsions, kidney failure, liver failure, clotting problems or mortality.
  • secondary villi - (secondary chorionic villi) Term describing the second stage of embryonic placenta development. In humans, the conceptus during week 3 onward this stage of chorionic villi development consists of the trophoblastic shell cells (syncytiotrophoblast and cytotrophoblasts) filled with extraembryonic mesoderm forming finger-like extensions into maternal decidua. Initially these finger-like projections cover the entire surface of chorionic sac and later become restricted to the placental surface. The villi stages are ongoing as the placenta continues to grow through both the embryonic and fetal development. Placental villi stages: primary villi - secondary villi - tertiary villi
  • syncytiotrophoblast - A multinucleated cell currently thought to form by the fusion of another trophoblast cell the cytotrophoblasts, within the trophoblast layer (shell) of the implanting conceptus. In early development, these cells mediate implantation of the conceptus into the uterine wall and secrete the hormone (human Chorionic Gonadotrophin, hCG) responsible for feedback maintainance of the corpus luteum (in maternal ovary) and therefore maintaining early pregnancy.
  • trophoblast - (trophectoderm, Greek, trophe = "nutrition" and blast = a primordial cell) cells that firstly support adplantation, implantation and endocrine support of pregnancy. Contribute to the extraembryonic tissues, fetal placenta and membranes. Initially form 2 populations individual cytotrophoblast cells and their fused multinucleate syncytiotrophoblast cells.
  • umbilical cord (placental cord) fetal attachment cord 1-2 cm diameter, 30-90cm long, covered with amniotic attached to chorionic plate, umbilical vessels (artery, vein) branch into chorionic vessels. Vessels anastomose within the placenta.
  • vasculogenesis - formation of first blood vessels by differentiation of pluripotent mesenchymal cells (extraembryonic mesoderm) followed by angiogenesis which is the development of new vessels from already existing vessels.
  • villi - Plural of villus, which is a thin projection from a surface. The term in development is used to describe the individual functional units together of the fetal placenta.
  • virus - small infectious agents that may cross the placental barrier. Can infect embryo and/or placenta and cause developmental abnormalities. (e.g. cytomegalovirus, rubella, measles).
  • Wharton's jelly - Placental cord (umbilical cord) gelatinous connective tissue composed of myofibroblast-like stromal cells, collagen fibers, and proteoglycans. Increases in volume (myxomatous, connective tissue embedded in mucus) at parturition (birth) to assist closure of placental blood vessels. Matrix cells from Wharton's jelly have recently been identified as a potential source of mesenchymal stem cells (MSC), also called mesenchymal stromal cell. This placental cord substance is named after Thomas Wharton (1614-1673) an English physician and anatomist who first described this placental tissue.
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Cite this page: Hill, M.A. 2017 Embryology Placenta Development. Retrieved December 18, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Placenta_Development

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G