Embryology - 29 Nov 2023 Expand to Translate
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Bossy J. Development of olfactory and related structures in staged human embryos. (1980) Anat. Embryol., 161(2);225-36 PMID 7469043

Online Editor

This historic 1980 paper by Bossy described development olfactory and related structures in staged human embryos from the Carnegie Collection.

Modern Notes smell

Historic Embryology - Smell
Historic Embryology: 1902 Olfactory Structures \| 1910 cavum nasi \| 1940 Olfactory and Accessory Olfactory Formations \| 1941 Olfactory nerve \| 1944 Jacobson’s organ \| 1980 Staged embryos

Historic Head Embryology
1910 Skull \| 1910 Skull Images \| 1912 Nasolacrimal Duct \| 1921 Human Brain Vascular \| 1923 Head Subcutaneous Plexus \| 1919 21mm Embryo Skull \| 1920 Human Embryo Head Size \| 1921 43 mm Fetal Skull \| Historic Disclaimer

Historic Embryology - Respiratory
1902 The Nasal Cavities and Olfactory Structures \| 1906 Lung \| 1912 Upper Respiratory Tract \| 1912 Respiratory \| 1913 Prenatal and Neonatal Lung \| 1914 Phrenic Nerve \| 1918 Respiratory images \| 1921 Respiratory \| 1922 Chick Pulmonary Vessels \| 1934 Right Fetal Lung \| 1936 Early Human Lung \| 1937 Terminal Air Passages \| 1938 Human Histology

Search PubMed nasal cavity development

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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History \| Historic Embryology Papers)

Development of Olfactory and Related Structures in Staged Human Embryos

J. Bossy

Supported by research programme project grant No. HD-08658, Institute of Child Health and Human Development, National Institutes of Health (USA)

Summary

The staged sequence of development of the olfactory and related structures has been established from the serially sectioned human embryos of the Carnegie Collection, from stage 11 to stage 23.

The nasal epiblastic thickening appears at stage 11 and the nasal field is well outlined at stage 12. At stage 15, a continuous cellulovascular strand is observed between the nasal groove and the olfactory field. The vomeronasal groove appears at stage 16 (O'Rahilly 1967). During stage 17, the olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex. The olfactory bulb begins to appear at stage 18. Stage 19 is characterized by the individualization of the olfactory bulb and nuclei. In addition, the distinction between olfactory structures and terminal and vomeronasal ones begins to be clear. The structure of the olfactory bulb is evident at stage 21. At stage 23, the olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.

The terminal ganglion is rather terminal-vomeronasal with an autonomic terminal contingent and a sensory one attached to the vomeronasal system.

Historic Papers

Human embryos and fetuses - (Hines 1922; Humphrey 1940; Lazorthes 1944; van Campenhout 1948; Larsell 1950; Humphrey 1963, 1966, 1967, 1968); O'Rahilly 1965, 1967 staged human embryos.

Animal - (van Campenhout 1936).

Carnegie Stages

11 - the nasal epiblastic thickening appears
12 - nasal field is well outlined
15 - a continuous cellulovascular strand is observed between the nasal groove and the olfactory field.
16 - the vomeronasal groove appears.
17 - the olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex.
18 - the olfactory bulb begins to appear.
19 - individualization of the olfactory bulb and nuclei. In addition, the distinction between olfactory structures and terminal and vomeronasal ones begins to be clear.
21 - the structure of the olfactory bulb is evident.
23 - the olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.

**Embryonic Smell Development**
Week FA (GA)	Carnegie Stage	Event
week 4 (GA 6)	11	nasal epiblastic thickening appears
	12	nasal field is well outlined
week 5 (GA 7)	15	continuous cellulovascular strand seen between the nasal groove and the olfactory field
week 6 (GA 8)	16	vomeronasal groove appears.
	17	olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex.
week 7 (GA 9)	18	olfactory bulb begins to appear
	19	individualization of the olfactory bulb and nuclei, distinction between olfactory structures and terminal and vomeronasal ones begins to be clear.
week 8 (GA 10)	21	structure of the olfactory bulb is evident.
	23	olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.
Links: smell \| sensory \| timeline \| Category:Timeline Table Data Reference^[1]

References

Campenhout E van (1936) Origine du nerf olfactif chez le porc. Arch Anat Microsc 32:391–407

Campenhout E van (1948) La contribution des placodes épiblastiques au développement des ganglions des nerfs crâniens chez l'embryon humain. Arch Biol (Paris) 59:253–266

Campenhout E van (1957) Le développement embryonnaire comparé des nerfs olfactif et auditif. Acta Otorhinolaryngol Belg 11:279–287

Detwiler SR (1936) Neuroembryology, an experimental study. Macmillan New York

Fagnart JR (1950) Le système nerveux périphérique crânien d'un embryon humain de 29 mm. Arch Biol Liège 61:151–186

Hamburger V (1961) Experimental analysis of the dual origin of the trigeminal ganglion in the chick embryo. J Exp Zool 148(3):91–123

Hines M. Studies in the growth and differentiation of the telencephalon in man - the fissura hippocampi. (1922) J. Comp. Neural. 3(1): 73-171.

Humphrey T. The development of the olfactory and the accessory olfactory formations in human embryos and fetuses. (1940) J. Comp. Neurol. 431-468.

Humphrey T (1963) The development of the anterior olfactory nucleus of human fetuses. Progress in brain research, Elsevier Amsterdam Vol 3, pp 170–190

Humphrey T (1966) Correlations between the development of the hippocampal formation and the differentiation of the olfactory bulb. Ala J Med Sci 3:235–269

Humphrey T (1967) The development of the human tuberculum olfactorium during the first three months of embryonic life. J Hirnforsch 9:437–469

Humphrey T (1968) The development of the human amygdala during early embryonic life. J Comp Neurol 132:135–165

Larsell O (1950) The nervus terminalis. Ann Otolaryngol 59:414–438

Lazorthes G (1944) Le nerf terminal... premier nerf crânien? Etude chez l'homme et quelques mammifères. Toulouse: Thèse de Sciences Naturelles

Masy S (1955), Le système nerveux périphérique crânien de l'embryon humain de 9 mm. J Embryol Exp Morphol 3:30–43

O'Rahilly R (1965) The optic, vestibulocochlear, and terminal-vomeronasal neural crest in staged human embryos. In: Rohen JW (ed) Eye structure, II symposium. Schattauer-Verlag Stuttgart pp 557–564

O'Rahilly R (1967) The early development of the nasal pit in staged human embryos. Anat Rec 157:380

Pearson AA. The development of the olfactory nerve in man. (1941) J Comp. Neurol. 199-217.

Pearson AA. The development of the nervus terminali in man. (1941) J Comp. Neurol. 75: 39-66.

Verwoerd CDA, Oostrom CG van (1979) Cephalic neural crest and placodes. Adv Anat Embryol Cell Biol 58:1–75

Cite this page: Hill, M.A. (2023, November 29) Embryology Paper - Development of olfactory and related structures in staged human embryos. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Development_of_olfactory_and_related_structures_in_staged_human_embryos

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