Paper - Development of olfactory and related structures in staged human embryos

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Bossy J. Development of olfactory and related structures in staged human embryos. (1980) Anat. Embryol., 161(2);225-36 PMID 7469043

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This historic 1980 paper by Bossy described development olfactory and related structures in staged human embryos from the Carnegie Collection.




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Development of Olfactory and Related Structures in Staged Human Embryos

J. Bossy


Supported by research programme project grant No. HD-08658, Institute of Child Health and Human Development, National Institutes of Health (USA)

Summary

The staged sequence of development of the olfactory and related structures has been established from the serially sectioned human embryos of the Carnegie Collection, from stage 11 to stage 23.


The nasal epiblastic thickening appears at stage 11 and the nasal field is well outlined at stage 12. At stage 15, a continuous cellulovascular strand is observed between the nasal groove and the olfactory field. The vomeronasal groove appears at stage 16 (O'Rahilly 1967). During stage 17, the olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex. The olfactory bulb begins to appear at stage 18. Stage 19 is characterized by the individualization of the olfactory bulb and nuclei. In addition, the distinction between olfactory structures and terminal and vomeronasal ones begins to be clear. The structure of the olfactory bulb is evident at stage 21. At stage 23, the olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.


The terminal ganglion is rather terminal-vomeronasal with an autonomic terminal contingent and a sensory one attached to the vomeronasal system.

Historic Papers

Human embryos and fetuses - (Hines 1922; Humphrey 1940; Lazorthes 1944; van Campenhout 1948; Larsell 1950; Humphrey 1963, 1966, 1967, 1968); O'Rahilly 1965, 1967 staged human embryos.

Animal - (van Campenhout 1936).


Carnegie Stages

  • 11 - the nasal epiblastic thickening appears
  • 12 - nasal field is well outlined
  • 15 - a continuous cellulovascular strand is observed between the nasal groove and the olfactory field.
  • 16 - he vomeronasal groove appears.
  • 17 - the olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex.
  • 18 - the olfactory bulb begins to appear.
  • 19 - individualization of the olfactory bulb and nuclei. In addition, the distinction between olfactory structures and terminal and vomeronasal ones begins to be clear.
  • 21 - the structure of the olfactory bulb is evident.
  • 23 - the olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.


Embryonic Smell Development
Week FA (GA) Carnegie Stage Event
week 4 (GA 6) 11 nasal epiblastic thickening appears
12 nasal field is well outlined
week 5 (GA 7) 15 continuous cellulovascular strand seen between the nasal groove and the olfactory field
week 6 (GA 8) 16 vomeronasal groove appears.
17 olfactory nerve is organized into two plexuses, lateral and medial, the latter mingled with the terminal-vomeronasal complex.
week 7 (GA 9) 18 olfactory bulb begins to appear
19 individualization of the olfactory bulb and nuclei, distinction between olfactory structures and terminal and vomeronasal ones begins to be clear.
week 8 (GA 10) 21 structure of the olfactory bulb is evident.
23 olfactory strands are well individualized, and olfactory and terminal-vomeronasal fibers are easily distinguishable.
Links: smell | sensory | timeline | Category:Timeline    Table Data Reference[1]


References

Campenhout E van (1936) Origine du nerf olfactif chez le porc. Arch Anat Microsc 32:391–407


Campenhout E van (1948) La contribution des placodes épiblastiques au développement des ganglions des nerfs crâniens chez l'embryon humain. Arch Biol (Paris) 59:253–266


Campenhout E van (1957) Le développement embryonnaire comparé des nerfs olfactif et auditif. Acta Otorhinolaryngol Belg 11:279–287


Detwiler SR (1936) Neuroembryology, an experimental study. Macmillan New York


Fagnart JR (1950) Le système nerveux périphérique crânien d'un embryon humain de 29 mm. Arch Biol Liège 61:151–186


Hamburger V (1961) Experimental analysis of the dual origin of the trigeminal ganglion in the chick embryo. J Exp Zool 148(3):91–123


Hines M. Studies in the growth and differentiation of the telencephalon in man - the fissura hippocampi. (1922) J. Comp. Neural. 3(1): 73-171.


Humphrey T. The development of the olfactory and the accessory olfactory formations in human embryos and fetuses. (1940) J. Comp. Neurol. 431-468.


Humphrey T (1963) The development of the anterior olfactory nucleus of human fetuses. Progress in brain research, Elsevier Amsterdam Vol 3, pp 170–190


Humphrey T (1966) Correlations between the development of the hippocampal formation and the differentiation of the olfactory bulb. Ala J Med Sci 3:235–269


Humphrey T (1967) The development of the human tuberculum olfactorium during the first three months of embryonic life. J Hirnforsch 9:437–469


Humphrey T (1968) The development of the human amygdala during early embryonic life. J Comp Neurol 132:135–165


Larsell O (1950) The nervus terminalis. Ann Otolaryngol 59:414–438


Lazorthes G (1944) Le nerf terminal... premier nerf crânien? Etude chez l'homme et quelques mammifères. Toulouse: Thèse de Sciences Naturelles


Masy S (1955), Le système nerveux périphérique crânien de l'embryon humain de 9 mm. J Embryol Exp Morphol 3:30–43


O'Rahilly R (1965) The optic, vestibulocochlear, and terminal-vomeronasal neural crest in staged human embryos. In: Rohen JW (ed) Eye structure, II symposium. Schattauer-Verlag Stuttgart pp 557–564


O'Rahilly R (1967) The early development of the nasal pit in staged human embryos. Anat Rec 157:380


Pearson AA. The development of the olfactory nerve in man. (1941) J. Comp. Neurol. 199-217.


Pearson AA. The development of the nervus terminali in man. (1941) J. Comp. Neurol. 75: 39-66.


Verwoerd CDA, Oostrom CG van (1979) Cephalic neural crest and placodes. Adv Anat Embryol Cell Biol 58:1–75


Cite this page: Hill, M.A. (2018, December 10) Embryology Paper - Development of olfactory and related structures in staged human embryos. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Development_of_olfactory_and_related_structures_in_staged_human_embryos

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  1. Bossy J. Development of olfactory and related structures in staged human embryos. (1980) Anat. Embryol., 161(2);225-36 PMID 7469043