Maternal Immune
Embryology - 25 May 2024 ![]() ![]() ![]() |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
![Image of human conceptus fully implanted](/embryology/images/thumb/c/ce/Stage5_bf11L.jpg/300px-Stage5_bf11L.jpg)
![Uterine Leukemia Inhibitory Factor (LIF) Expression](/embryology/images/thumb/2/2b/Implantation_LIF.jpg/300px-Implantation_LIF.jpg)
How does the implanting conceptus avoid immune rejection by the maternal immune system? There are a number of maternal and embryonic mechanisms that are thought to act to prevent immune rejection of the implanting conceptus, though the complete mechanism(s) are unknown. This is particularly relevant to Assisted Reproductive Technologies involving donor eggs.
Recent studies have also identified innate lymphoid cells (ILCs) are present in the uterus during the first trimester.[2] Innate lymphoid cells form three main groups: ILC1, ILC2, and ILC3. The ILC1 group include natural killer (NK) cells and other interferon (IFN)γ-producing cells.
developmentally related hematopoietic cells, which contribute to host immune defenses.
Some Recent Findings
|
More recent papers |
---|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Maternal Immune <pubmed limit=5>Maternal Immune</pubmed> Search term: Uterine natural killer <pubmed limit=5>Uterine natural killer</pubmed> Search term: decidual natural killer cells <pubmed limit=5>decidual natural killer cells</pubmed> |
Decidual Immune Cells
Decidual Macrophages (Mϕ) | Decidual T cells | Uterine Natural Killer cells |
---|---|---|
|
|
|
Chemokine Gene Silencing
- Remove the attraction of maternal immune cells.
A mouse study[4] has shown that the normal immune response to inflammation, accumulation of effector T cells in response to chemokine secretion does not occur during implantation. This is prevented locally by epigenetic silencing of chemokine expression in the decidual stromal cells.
Corticotropin-Releasing Hormone
- Kill the maternal immune cells.
Both maternal and implanting conceptus release CRH at the embryo implantation site. This hormone then binds to receptors on the surface of trophoblast (extravillous trophoblast) cells leading to expression of a protein (Fas ligand, FasL) that activates the extrinsic cell death pathway on any local maternal immune cells ( T and B lymphocytes, natural killer cells, monocytes and macrophages).[7] This cannot be the only mechanism, as mice with dysfunctional FasL proteins are still fertile.
- Links: Implantation
Uterine Natural Killer Cells
Uterine Natural Killer or decidual NK (dNK) function to establishment of an immunosuppressive environment in comparison to circulating Natural Killer cells.
Circulating Natural Killer (NK) cells form part of the normal immune defence:
- have the ability to kill virus-infected cells and tumor cells
- release cytokines and chemokines involved in early inflammatory responses.
- regulated by inhibitory receptors and activating receptors
- inhibitory receptors - killer Ig-like receptors (KIRs) and CD94/NKG2A).
- activating receptors - (natural cytotoxicity receptors) NKp46, NKp30, and NKp44.
Implantation Factors
Molecular Implantation and Decidualization[8]
Cytokines
In mice, endometrial secretion of two IL-6 family cytokines, leukemia inhibitory factor (LIF) and Interleukin-11 (IL-11), are key requirements for implantation. A recent human study suggests that there is a similar requirement for human conceptus implantation.[9]
Uterine Leukemia Inhibitory Factor (LIF) Expression[1]
a - At day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen. There, LIF binds to its receptors on the surface of epithelial cells. | b - This makes the uterus receptive to the blastocyst, which implants by day 5 of pregnancy. Hu et al. find that LIF expression in the endometrial glands also depends on the regulatory activity of p53. In the absence of p53, insufficient LIF is produced, the uterus does not become adequately receptive, and fewer blastocysts implant. |
References
- ↑ 1.0 1.1 <pubmed>18046411</pubmed>
- ↑ <pubmed>25052762</pubmed>| Mucosal Immunol.
- ↑ <pubmed>25708533</pubmed>
- ↑ 4.0 4.1 <pubmed>22679098</pubmed>
- ↑ <pubmed>20976164</pubmed>| PMC2955532 | PLoS One
- ↑ <pubmed>20729534</pubmed>
- ↑ <pubmed>11590404</pubmed>
- ↑ <pubmed>23223073</pubmed>| Nat Med
- ↑ <pubmed>19213836</pubmed>
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed>25713505</pubmed> <pubmed>25342175</pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed>25310696</pubmed> <pubmed>25163504</pubmed> <pubmed>25066422</pubmed> <pubmed>24954221</pubmed> <pubmed>24954224</pubmed> <pubmed></pubmed> <pubmed></pubmed>
Search PubMed
Search Pubmed: Embryo Adplantation | Embryo Implantation | tubal pregnancy | Endometrial Receptivity | Placenta Abnormalities | Pinopods | decidualization
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 25) Embryology Maternal Immune. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Maternal_Immune
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G