Developmental Signals - Pax
Embryology - 26 Apr 2024 Expand to Translate |
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Introduction
The name derived from Drosophila gene "paired" (prd) with a box (homeodomain) domain. A transcription factor of the helix-turn-helix structural family, DNA binding, and activating gene expression. In human, there are nine member proteins from Pax1 to Pax9.
Pax6 has been identified as regulating development of the central nervous system, eyes, nose, pancreas and pituitary gland.
Developmental Functions: Mesoderm | Neural | Vision | Pancreas | Pituitary| Thymus
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Development Pax <pubmed limit=5>Development Pax</pubmed> |
Transcription Factor
Pax and DNA molecular interaction[2]
Mesoderm Development
Mesoderm Development and Pax[2]
Neural Development
- Hoxd4 gene a direct target of Pax6[5]
- mouse embryo - Hoxd4 expression in rhombomere 7 and the spinal cord is reduced to some extent in the Pax6 mutant
- zebrafish embryo - double knockdown of pax6a and pax6b with MOs resulted in malformed rhombomere boundaries and an anteriorized hoxd4a expression border
- Pax3 is expressed in the somite, neural tube, and neural crest.
- Pax3 is required for enteric ganglia formation.[6]
- Pax2 and Pax5 in midbrain and cerebellum development.[7]
Vision Development
Pax6 mutation eye phenotypes[8]
Pancreas Development
Molecular Development of Endocrine Pancreas Cells[10]
Thymus DevelopmentPax1 mouse KO thymus size reduction and impaired thymocyte maturation. Structure
Mouse ExpressionThe following gallery is from a recent paper using a Pax7-cre/reporter mouse.[12] Mouse Palatal Shelf Wnt5a, Osr2 and Pax9 Expression.[13]
AbnormalitiesAssociated with defects in each Pax protein or their signaling pathway. PAX2
Pax3
Pax5
PAX6A series of vision associated defects.
Pax7
PAX8
References
Search Bookshelf Pax Reviews<pubmed>17506689</pubmed> <pubmed>10197584</pubmed> Search PubmedSearch Pubmed Now: Pax http://www.ncbi.nlm.nih.gov/omim External LinksExternal Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Glossary Links
Cite this page: Hill, M.A. (2024, April 26) Embryology Developmental Signals - Pax. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Pax
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