Developmental Signals - Notch: Difference between revisions
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* '''Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors'''<ref name=PMID25564622><pubmed>25564622</pubmed></ref> "Basal cells are multipotent airway progenitors that generate distinct epithelial cell phenotypes crucial for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation to form the pseudostratified airway epithelium in the developing and adult lung. Here, we show by genetic and pharmacological approaches that endogenous activation of Notch3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available for differentiation. This mechanism depends on the availability of Jag1 and Jag2, and is key to generating a population of parabasal cells that later activates Notch1 and Notch2 for secretory-multiciliated cell fate selection." [[Respiratory System Development]] | |||
* '''Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb'''<ref name=PMID24927569><pubmed>24927569</pubmed></ref> "Multipotent Pax3-positive (Pax3(+)) cells in the somites give rise to skeletal muscle and to cells of the vasculature. We had previously proposed that this cell-fate choice depends on the equilibrium between Pax3 and Foxc2 expression. In this study, we report that the Notch pathway promotes vascular versus skeletal muscle cell fates. ...We now demonstrate that in addition to the inhibitory role of Notch signaling on skeletal muscle cell differentiation, the Notch pathway affects the Pax3:Foxc2 balance and promotes the endothelial versus myogenic cell fate, before migration to the limb, in multipotent Pax3(+) cells in the somite of the mouse embryo." [[Musculoskeletal_System_-_Limb_Development|Limb Development]] | [[Musculoskeletal_System_-_Muscle_Development|Muscle Development]] | * '''Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb'''<ref name=PMID24927569><pubmed>24927569</pubmed></ref> "Multipotent Pax3-positive (Pax3(+)) cells in the somites give rise to skeletal muscle and to cells of the vasculature. We had previously proposed that this cell-fate choice depends on the equilibrium between Pax3 and Foxc2 expression. In this study, we report that the Notch pathway promotes vascular versus skeletal muscle cell fates. ...We now demonstrate that in addition to the inhibitory role of Notch signaling on skeletal muscle cell differentiation, the Notch pathway affects the Pax3:Foxc2 balance and promotes the endothelial versus myogenic cell fate, before migration to the limb, in multipotent Pax3(+) cells in the somite of the mouse embryo." [[Musculoskeletal_System_-_Limb_Development|Limb Development]] | [[Musculoskeletal_System_-_Muscle_Development|Muscle Development]] | ||
* '''The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network'''<ref name=PMID24304493><pubmed>24304493</pubmed>| [http://www.biomedcentral.com/1471-213X/13/42 BMC Dev Biol.]</ref> "In vertebrate development, the segmental pattern of the body axis is established as somites, masses of mesoderm distributed along the two sides of the neural tube, are formed sequentially in the anterior-posterior axis. This mechanism depends on waves of gene expression associated with the Notch, Fgf and Wnt pathways." | * '''The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network'''<ref name=PMID24304493><pubmed>24304493</pubmed>| [http://www.biomedcentral.com/1471-213X/13/42 BMC Dev Biol.]</ref> "In vertebrate development, the segmental pattern of the body axis is established as somites, masses of mesoderm distributed along the two sides of the neural tube, are formed sequentially in the anterior-posterior axis. This mechanism depends on waves of gene expression associated with the Notch, Fgf and Wnt pathways." | ||
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===Endoderm Development=== | |||
Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study<ref name=PMID25564622><pubmed>25564622</pubmed></ref> has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate. | |||
:'''L;inks:''' [[Respiratory System Development]] | |||
===Mesoderm Development=== | ===Mesoderm Development=== | ||
Revision as of 09:04, 29 August 2015
Embryology - 26 Apr 2024 Expand to Translate |
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Introduction
The notch proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.
- Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Notch <pubmed limit=5>Notch</pubmed> |
Notch Signaling
Notch signaling pathway[1]
(text from original figure legend) |
Notch Receptors
NOTCH1
NOTCH2
NOTCH3
- Notch3 activation retains mammary luminal cell in a nonproliferative state.[9]
NOTCH4
Notch Ligands
- JAG1
- JAG2
- DLL1
- DLL3
- DLL4
Functions
Developmental patterning signal.
Spinal Cord Development
Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.[10]
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Endoderm Development
Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study[3] has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.
- L;inks: Respiratory System Development
Mesoderm Development
Cartilage Development
Muscle Regeneration
Notch signalling in muscle regeneration[11]
Hypothalamus Development
Hypothalamus Development Gene Interaction Model[12]
- Links: Hypothalamus Development
Abnormalities
Alagille Syndrome
Mutations in the human homolog of Jagged-1 (JAG1) located on chromosome 20p12 cause Alagille Syndrome. Abnormalities are seen in gastrointestinal (liver cholestasis), cardiac (heart), renal (kidney), skeletal, ocular, and facial systems.
- Links: Alagille Syndrome
References
- ↑ 1.0 1.1 <pubmed>19255248</pubmed>
- ↑ 2.0 2.1 <pubmed>24304493</pubmed>| BMC Dev Biol.
- ↑ 3.0 3.1 <pubmed>25564622</pubmed>
- ↑ <pubmed>24927569</pubmed>
- ↑ <pubmed>20513039</pubmed>
- ↑ <pubmed>19590010</pubmed>
- ↑ <pubmed>19590010</pubmed>
- ↑ <pubmed>19161597</pubmed>
- ↑ <pubmed>24100291</pubmed>
- ↑ <pubmed>18000541</pubmed>| PLoS ONE
- ↑ <pubmed>24472470</pubmed>| BMC Dev Biol.
- ↑ 24360028<pubmed>24360028</pubmed>| Neural Dev.
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed>23165243</pubmed> <pubmed> 22399351</pubmed> <pubmed>22397947</pubmed> <pubmed>21828089</pubmed>
Search Pubmed
Search Bookshelf Notch
Search Pubmed Now: Notch Signaling
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- OMIM - NOTCH 1
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 26) Embryology Developmental Signals - Notch. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Notch
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G