Developmental Signals - Nanog: Difference between revisions
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==Some Recent Findings== | ==Some Recent Findings== | ||
==Some Recent Findings== | |||
[[File:Stimulus-triggered acquisition of pluripotency 01.jpg|thumb|STAP now discredited.]] | |||
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* '''Phosphorylation stabilizes Nanog by promoting its interaction with Pin1'''<ref name="PMID20622153"><pubmed>20622153</pubmed></ref>"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms." | * '''Phosphorylation stabilizes Nanog by promoting its interaction with Pin1'''<ref name="PMID20622153"><pubmed>20622153</pubmed></ref>"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms." | ||
* '''Nanog variability and pluripotency regulation of embryonic stem cells'''<ref name="PMID20574542"><pubmed>20574542</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011238 PLoS One]</ref>"The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression of Nanog and that individual ES cells reversibly change their Nanog expression level." | |||
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! More recent papers | |||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Nanog ''Nanog''] | |||
<pubmed limit=5>Nanog</pubmed> | |||
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==Classification== | ==Classification== |
Revision as of 18:58, 15 June 2015
Embryology - 27 Apr 2024 Expand to Translate |
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Introduction
NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nanog <pubmed limit=5>Nanog</pubmed> |
Classification
Functions
Required for embryonic stem cell self-renewal.
Spermatogenesis
The cartoons below show nanog expression in mouse and dog during spermatogenesis.[4]
Signaling Pathway
Two-level process for the induction of stem cell differentiation[3] |
References
Search Pubmed
Search Pubmed Now: Nanog
Search OMIM Nanog
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Entrez Gene - NANOG Nanog homeobox - Homo sapiens
- OMIM - 607937 NANOG
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 27) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G