Developmental Signals - Nanog: Difference between revisions
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==Human NANOG Family== | |||
{{Nanog family table}} | |||
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{{Nanog family collapsetable}} | |||
==Classification== | ==Classification== |
Revision as of 17:06, 17 January 2018
Embryology - 4 May 2024 Expand to Translate |
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Introduction
NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. Human NANOG is a transcription factor protein of 305 amino acids with a conserved homeodomain motif that is localized to the nucleus.
First identified in mouse ES cells in a 2003 study[2], the author (Chambers) named the factor after an Irish myth, Tír na nÓg ("Land of the Young") as it makes stem cells immortal.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nanog <pubmed limit=5>Nanog</pubmed> |
Human NANOG Family
Table - Human Nanog Family - pseudogenes | ||||
Approved Symbol |
Approved Name | Previous Symbols | Chromosome | |
---|---|---|---|---|
NANOG | Nanog homeobox | FLJ12581, FLJ40451 | 12p13.31 | |
NANOG P1 | Nanog homeobox pseudogene 1 | NANOG2 | 12p13.31 | |
NANOG P2 | Nanog homeobox pseudogene 2 | NANOGP4 | 2q36.1 | |
NANOG P3 | Nanog homeobox pseudogene 3 | 6p12.1 | ||
NANOG P4 | Nanog homeobox pseudogene 4 | NANOGP2 | 7p14.3 | |
NANOG P5 | Nanog homeobox pseudogene 5 | 9q31.1 | ||
NANOG P6 | Nanog homeobox pseudogene 6 | 10q24.2 | ||
NANOG P7 | Nanog homeobox pseudogene 7 | NANOGP3 | 14q32.12 | |
NANOG P8 | Nanog homeobox retrogene P8 | 15q14 | ||
NANOG P9 | Nanog homeobox pseudogene 9 | Xq12 | ||
NANOG P10 | Nanog homeobox pseudogene 10 | Xp11.3 | ||
NANOG P11 | Nanog homeobox pseudogene 11 | 6q25.2 | ||
Links: Developmental Signals - Nanog | OMIM | HGNC | Tbx Family |
Human NANOG Family | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Classification
Functions
Required for embryonic stem cell self-renewal.
Blastocyst - Inner Cell Mass
In the early mouse embryo, Nano expression appears to be related to maintain of pluripotency in the blastocyst inner cell mass epiblast layer.[3]
Nanog expression pattern four phases:
- cleavage stages - very low levels
- morula stage - increased stochastically, no correlation with future cell fates.
- blastocyst stage (after 32-cell stage) - inner cell mass expression was up-regulated.
- blastocyst stage onwards - primitive endoderm repressed in an FGF signalling-dependent manner.
- Links: Morula | Blastocyst | Mouse Development | FGF
Spermatogenesis
The cartoons below show nanog expression in mouse and dog during spermatogenesis.[6]
Signaling Pathway
Two-level process for the induction of stem cell differentiation[5] |
References
Search Pubmed
Search Pubmed Now: Nanog
Search OMIM Nanog
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Entrez Gene - NANOG Nanog homeobox - Homo sapiens
- OMIM - NANOG
Glossary Links
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Cite this page: Hill, M.A. (2024, May 4) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G