2009 Lecture 7: Difference between revisions
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* '''Cardiovascular Movies''' | * '''Cardiovascular Movies''' | ||
* '''Cardiovascular Notes''' | * '''Cardiovascular Notes''' | ||
== Development Overview == | |||
The heart develops from cardiogenic mesoderm that originally lies above the cranial end of the developing neural tube. Enlargement of the cranial neural fold brings this region ventrally to its correct anatomical position. The original paired cardiac tubes fuse, with the "ventricular" primordia initially lying above the "atria". Growth of the cardiac tube flexes it into an "S-shape" tube, rotating the "ventricles" downward and pushing the "atria" upward. This is then followed by septation, a complex process which converts this simple tube into a four chambered heart. A key part of this process is the separation of cardiac outflow (truncus arteriosus) into a separate pulmonary and aortic arch outflow. During embryonic development there is extensive remodelling of the initially right and left symmetrical cardiovascular system and a contribution from the neural crest to some vessels. | |||
==UNSW Embryology Links== | ==UNSW Embryology Links== | ||
Revision as of 09:01, 15 August 2009
Early Vascular Development
Introduction
This lecture will introduction to the events in early embryonic development that relate to mesoderm and early cardiovascular development. Most texts will separate heart development from vascular development in order to simplify their descriptions of cardiovascular development, though the two are functionally and embryonically connected. Note that we will be returning later to discuss the late development of the heart and vascular changes.
Lecture Objectives
- Understanding of mesoderm development
- Understanding of heart tube formation and early development
- Understanding of early blood vessel and blood development
- Brief understanding of vascular growth and regression
- Brief understanding of vascular growth factors
Textbook References
- Human Embryology (3rd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Chapter 14: p304-349
Other textbooks
- Before we Are Born (5th ed.) Moore and Persaud Chapter 12; p241-254
- Essentials of Human Embryology Larson Chapter 7 p97-122 Heart, Chapter 8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Chapter 13-17: p77-111
UNSW Embryology Links
- Cardiovascular Slides Cardiovasular Lecture 7 2008 | Heart Lecture 2008 - 1 slide/page | Heart Lecture 2008 Slides - 4 slides/page | Heart Lecture 2008 Slides - 6 slides/page
- Cardiovascular Movies
- Cardiovascular Notes
Development Overview
The heart develops from cardiogenic mesoderm that originally lies above the cranial end of the developing neural tube. Enlargement of the cranial neural fold brings this region ventrally to its correct anatomical position. The original paired cardiac tubes fuse, with the "ventricular" primordia initially lying above the "atria". Growth of the cardiac tube flexes it into an "S-shape" tube, rotating the "ventricles" downward and pushing the "atria" upward. This is then followed by septation, a complex process which converts this simple tube into a four chambered heart. A key part of this process is the separation of cardiac outflow (truncus arteriosus) into a separate pulmonary and aortic arch outflow. During embryonic development there is extensive remodelling of the initially right and left symmetrical cardiovascular system and a contribution from the neural crest to some vessels.
UNSW Embryology Links
Terms
angioblast - the embryonic precursor cell which will form the walls of both arteries and veins. (More? Blood Vessel)
bulbus cordis -common outflow tract region of the early developing heart tube. Blood Pathway: sinus venosus - atrium - ventricle - bulbus cordis (outflow tract) (More? Heart Notes)
cardinal vein - name given to the initial early vessels that will form the systemic venous system. System, like most vessels are initially bilaterally symmetrical. (More? Blood Vessel Notes | Cardiovascular Notes)
cardiocyte - cardiac muscle cell.
coarctation of the aorta - (Latin coartare = to press together) Term used to describe a developmental abnormality of narrowing (stricture, constriction) of the aortic arch. (More? Coarctation of Aorta)
splanchnic mesoderm - Embryonic origin of the gastrointestinal tract connective tissue, smooth muscle,, cardiac tissue and blood vessels. In the trilaminar embryo, the portion of the lateral plate mesoderm closest to the endoderm when this mesoderm is divided by formation of the intraembryonic coelom.
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Next Lecture
Cite this page: Hill, M.A. (2024, May 18) Embryology 2009 Lecture 7. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2009_Lecture_7
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
