Developmental Signals - Nodal
Embryology - 27 Jun 2024 Expand to Translate |
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Introduction
Nodal is a member of the TGF-beta family and together with Lefty both are involved in the initial left-right (L-R) patterning of the axis of the embryo during gastrulation. This patterning signal is later used for many cell fate developmental processes. This patterning role was first established in mouse and zebrafish models, the human homolog was first identified in 1997.[1]
Left-right (L-R) asymmetry include the position on the left side of the heart and spleen and the development of the curvature of the stomach.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nodal <pubmed limit=5>Nodal</pubmed> |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Nodal Signaling
Nodal represents a family of transmembrane receptors passing only once through the plasma membrane. Nodal acts through SMAD2 dependent and independent intracellular pathways.
Nodal Ligands
Functions
Developmental patterning signal.
Ectoderm Development
Stomach Development
- Stomach curvature is generated by left-right asymmetric gut morphogenesis[3] "Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here, we show in mouse and Xenopus that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including Foxj1, Nodal and Pitx2 Our findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts."
Abnormalities
- Links:
References
Reviews
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External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Online Mendelian Inheritance in Man (OMIM) NODAL | LEFTY1 | LEFTY2 | NODAL MODULATOR 1; NOMO1 | NODAL MODULATOR 2; NOMO2 | NODAL MODULATOR 3; NOMO3 |
Glossary Links
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Cite this page: Hill, M.A. (2024, June 27) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G