|Embryology - 20 Sep 2017 Expand to Translate|
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The middle layer of the early trilaminar embryo germ layers (ectoderm, mesoderm and endoderm) formed by gastrulation. The segmentation of the initial mesoderm into somites, and their regular addition, is often used to stage embryonic development (23 somite embryo).
This middle germ layer forms connective tissues and muscle throughout the body, with the exception of in the head region where some of these structures have a neural crest (ectoderm) origin.
- connective tissues - cartilage, bone, blood, blood vessel endothelium, dermis, etc.
- muscle - cardiac, skeletal, smooth.
Students often mix-up the terms mesoderm (middle layer) with mesenchyme (embryonic connective tissue). It is true that mesoderm initially does have a mesenchymal cellular organisation, but can also form a range of epithelial structures (surrounding somites, mesothelium lining of body cavities).
|Mesoderm Links: Endoderm | Mesoderm | Ectoderm | Lecture - Mesoderm | Lecture - Musculoskeletal | 2016 Lecture | Notochord | Notochord Movie | Somitogenesis | Musculoskeletal | Sonic hedgehog | Category:Mesoderm|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
A Berthon, F R Faucz, S Espiard, L Drougat, J Bertherat, C A Stratakis Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum. Mol. Genet.: 2017, 26(18);3495-3507 PubMed 28911199
Paul Bardot, Stéphane D Vincent, Marjorie Fournier, Alexis Hubaud, Mathilde Joint, László Tora, Olivier Pourquié The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development: 2017; PubMed 28893950
José M Martín-Durán, Yale J Passamaneck, Mark Q Martindale, Andreas Hejnol The developmental basis for the recurrent evolution of deuterostomy and protostomy. Nat Ecol Evol: 2016, 1(1);5 PubMed 28812551
Marc D Servetnick, Bailey Steinworth, Leslie S Babonis, David Simmons, Miguel Salinas-Saavedra, Mark Q Martindale Cas9-mediated excision of Nematostella brachyury disrupts endoderm development, pharynx formation, and oral-aboral patterning. Development: 2017; PubMed 28705897
Sha-Sha Bian, Xu-Lei Zheng, Hua-Qin Sun, Jian-Hui Chen, Yi-Lu Lu, Yun-Qiang Liu, Da-Chang Tao, Yong-Xin Ma Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signalings in the zebrafish embryo. J. Biol. Chem.: 2017; PubMed 28687631
Mesoderm Formation during Gastrulation
- Links: Gastrulation
- Timothy A. Sanders, Esther Llagostera, Maria Barna. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature Apr 28, 2013.
- Britannia M Fleming, Ronit Yelin, Richard G James, Thomas M Schultheiss A role for Vg1/Nodal signaling in specification of the intermediate mesoderm. Development: 2013, 140(8);1819-29 PubMed 23533180
- Alexander Aulehla, Olivier Pourquié Signaling gradients during paraxial mesoderm development. Cold Spring Harb Perspect Biol: 2010, 2(2);a000869 PubMed 20182616
- Irving M Shapiro, Makarand V Risbud Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Res. Ther.: 2010, 12(3);117 PubMed 20497604
Makarand V Risbud, Thomas P Schaer, Irving M Shapiro Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Dev. Dyn.: 2010, 239(8);2141-8 PubMed 20568241
Ann Campbell Burke Development and evolution of the vertebrate mesoderm. Dev. Dyn.: 2007, 236(9);2369-70 PubMed 17705304
Benjamin L Martin, David Kimelman Brachyury establishes the embryonic mesodermal progenitor niche. Genes Dev.: 2010, 24(24);2778-83 PubMed 21159819
Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther: 2010, 1(2);18 PubMed 20565707
P A Trainor, S S Tan, P P Tam Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos. Development: 1994, 120(9);2397-408 PubMed 7956820
J Florian The Early Development of Man, with Special Reference to the Development of the Mesoderm and Cloacal Membrane. J. Anat.: 1933, 67(Pt 2);263-76 PubMed 17104422
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Cite this page: Hill, M.A. 2017 Embryology Mesoderm. Retrieved September 20, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Mesoderm
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G