|Embryology - 21 Jan 2018 Expand to Translate|
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The middle layer of the early trilaminar embryo germ layers (ectoderm, mesoderm and endoderm) formed by gastrulation. The segmentation of the initial mesoderm into somites, and their regular addition, is often used to stage embryonic development (23 somite embryo).
This middle germ layer forms connective tissues and muscle throughout the body, with the exception of in the head region where some of these structures have a neural crest (ectoderm) origin.
- connective tissues - cartilage, bone, blood, blood vessel endothelium, dermis, etc.
- muscle - cardiac, skeletal, smooth.
Students often mix-up the terms mesoderm (middle layer) with mesenchyme (embryonic connective tissue). It is true that mesoderm initially does have a mesenchymal cellular organisation, but can also form a range of epithelial structures (surrounding somites, mesothelium lining of body cavities).
|Mesoderm Links: Endoderm | Mesoderm | Ectoderm | Lecture - Mesoderm | Lecture - Musculoskeletal | 2016 Lecture | Notochord | Notochord Movie | Somitogenesis | Musculoskeletal | Sonic hedgehog | Category:Mesoderm|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Conchi Estarás, Hui-Ting Hsu, Ling Huang, Katherine A Jones YAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineage. Genes Dev.: 2017; PubMed 29269485
Arica Beisaw, Pavel Tsaytler, Frederic Koch, Sandra U Schmitz, Maria-Theodora Melissari, Anna D Senft, Lars Wittler, Tracie Pennimpede, Karol Macura, Bernhard G Herrmann, Phillip Grote BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep.: 2017; PubMed 29141987
Carolina Blugüermann, Leonardo Romorini, Denis Evseenko, Ximena Garate, Gabriel Neiman, Gustavo Emilio Sevlever, María Elida Scassa, Santiago Gabriel Miriuka Leukemia Inhibitory Factor Increases Survival of Pluripotent Stem Cell-Derived Cardiomyocytes. J Cardiovasc Transl Res: 2017; PubMed 29019149
A Berthon, F R Faucz, S Espiard, L Drougat, J Bertherat, C A Stratakis Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum. Mol. Genet.: 2017, 26(18);3495-3507 PubMed 28911199
Paul Bardot, Stéphane D Vincent, Marjorie Fournier, Alexis Hubaud, Mathilde Joint, László Tora, Olivier Pourquié The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development: 2017; PubMed 28893950
Mesoderm Formation during Gastrulation
- Links: Gastrulation
- Timothy A. Sanders, Esther Llagostera, Maria Barna. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature Apr 28, 2013.
- Hisham Bazzi, Ekaterina Soroka, Heather L Alcorn, Kathryn V Anderson STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A.: 2017; PubMed 29203676
- Britannia M Fleming, Ronit Yelin, Richard G James, Thomas M Schultheiss A role for Vg1/Nodal signaling in specification of the intermediate mesoderm. Development: 2013, 140(8);1819-29 PubMed 23533180
- Alexander Aulehla, Olivier Pourquié Signaling gradients during paraxial mesoderm development. Cold Spring Harb Perspect Biol: 2010, 2(2);a000869 PubMed 20182616
- Irving M Shapiro, Makarand V Risbud Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Res. Ther.: 2010, 12(3);117 PubMed 20497604
Makarand V Risbud, Thomas P Schaer, Irving M Shapiro Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord. Dev. Dyn.: 2010, 239(8);2141-8 PubMed 20568241
Ann Campbell Burke Development and evolution of the vertebrate mesoderm. Dev. Dyn.: 2007, 236(9);2369-70 PubMed 17705304
Benjamin L Martin, David Kimelman Brachyury establishes the embryonic mesodermal progenitor niche. Genes Dev.: 2010, 24(24);2778-83 PubMed 21159819
Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther: 2010, 1(2);18 PubMed 20565707
P A Trainor, S S Tan, P P Tam Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos. Development: 1994, 120(9);2397-408 PubMed 7956820
J Florian The Early Development of Man, with Special Reference to the Development of the Mesoderm and Cloacal Membrane. J. Anat.: 1933, 67(Pt 2);263-76 PubMed 17104422
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Cite this page: Hill, M.A. 2018 Embryology Mesoderm. Retrieved January 21, 2018, from https://embryology.med.unsw.edu.au/embryology/index.php/Mesoderm
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G