Histology Artifacts

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Introduction

There are many steps in the preparation and processing of tissue sections that can introduce artefacts into the original tissue. This page introduces some of the steps in tissue preparation where this can occur and the type of artefact that appears in the final tissue. The pages on histology fixatives and stains should be read in conjunction with this page.

In histology, if it looks interesting, it is probably an artefact!



Draft page - Notice removed when completed.

Histology Links: stains | fixatives | artifacts | menstrual histology | placenta histology | heart histology | liver histology | Pancreas | Gall Bladder | Colon | Renal | Respiratory Histology | Bone | Category:Histology | UNSW Histology
  Historic Histology Textbooks: 1941 Histology] | 1944 Oral Histology
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Artifacts

  • Prefixation artifacts
  • Fixation artifacts
  • Artifacts related to bone tissue
  • Tissue-processing artifacts
  • Artifacts related to microtomy
  • Artifacts related to floatation and mounting
  • Staining artifacts
  • Mounting artifacts

Prefixation Artifacts

Anything that may have been done to the tissue before it has been preserved by fixation. This includes handling, physical distortion, drug treatments or injections, tissue degeneration, or poor tissue preparation for fixation.

Fixation Artifacts

Fixative solution osmolality

  • Hypertonic can cause cellular shrinkage and increased extracellular spaces.
  • Hypotonic can cause cell swelling.

References


Reviews

Taqi SA, Sami SA, Sami LB & Zaki SA. (2018). A review of artifacts in histopathology. J Oral Maxillofac Pathol , 22, 279. PMID: 30158787 DOI.

Chatterjee S. (2014). Artefacts in histopathology. J Oral Maxillofac Pathol , 18, S111-6. PMID: 25364159 DOI.

Bindhu P, Krishnapillai R, Thomas P & Jayanthi P. (2013). Facts in artifacts. J Oral Maxillofac Pathol , 17, 397-401. PMID: 24574659 DOI.

Rastogi V, Puri N, Arora S, Kaur G, Yadav L & Sharma R. (2013). Artefacts: a diagnostic dilemma - a review. J Clin Diagn Res , 7, 2408-13. PMID: 24298546 DOI.

Articles

Glossary Links

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Cite this page: Hill, M.A. (2019, September 19) Embryology Histology Artifacts. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Histology_Artifacts

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G