Developmental Signals - Fox

From Embryology
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Introduction

A protein transcription factor belonging to the evolutionarily conserved forkhead box (FOX) superfamily.

Draft page.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

  • Tbx1 is regulated by forkhead proteins in the secondary heart field.[1] "Transcriptional regulation in a tissue-specific and quantitative manner is essential for developmental events, including those involved in cardiovascular morphogenesis. Tbx1 is a T-box-containing transcription factor that is responsible for many of the defects observed in 22q11 deletion syndrome in humans. Tbx1 is expressed in the secondary heart field (SHF) and is essential for cardiac outflow tract (OFT) development....These results suggest that Fox proteins are involved in most, if not all, Tbx1 expression domains and that Tbx1 marks a subset of SHF-derived cells, particularly those that uniquely contribute to the right-sided outflow tract and proximal pulmonary artery." (More? Tbx | Cardiovascular System Development )
More recent papers  
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Search term: Fox

<pubmed limit=5>Fox</pubmed>

Transcription Factor

Abnormalities

Associated with defects in each Fox protein or their signaling pathway.


References

  1. Maeda J, Yamagishi H, McAnally J, Yamagishi C & Srivastava D. (2006). Tbx1 is regulated by forkhead proteins in the secondary heart field. Dev. Dyn. , 235, 701-10. PMID: 16444712 DOI.

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Cite this page: Hill, M.A. (2019, January 18) Embryology Developmental Signals - Fox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Fox

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G