Carnegie stage 8

Embryology - 5 Dec 2023        Expand to Translate
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Introduction

Gastrulation is continuing as cells migrate from the epiblast, continuing to form mesoderm. Mesoderm lies between the ectoderm and endoderm as a continuous sheet except at the buccopharyngeal and cloacal membranes. These membranes have ectoderm and endoderm only and will lie at the rostral (head) and caudal (tail) of the gastrointestinal tract. From the primitive node a tube extends under the ectoderm in the opposite direction to the primitive streak. This tube forms first the axial process then notochordal process, then finally the notochord. The notochord is a key to embryonic folding and regulation of ectoderm and mesoderm differentiation. It lies in the rostrocordal axis and the embryonic disc will fold either side ventrally, pinching off a portion of the yolk sac to form the lining of the gastrointestinal tract. Summary Human embryonic stage 8 occurs during week 3 between 17 to 19 days. The embryo is now 1.0 - 1.5 mm in size. Identify embryonic disc primitive node, primitive streak, primitive groove connecting stalk cut amniotic membrane See also Events Stage 8 Links: Week 3 | Gastrulation | Lecture | Lecture | Somitogenesis | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Science Practical | Carnegie Embryos | Category:Carnegie Stage 8 | Next Stage 9   Historic Papers: 1920 Mateer Embryo | 1931 Head-Process | 1931 Prochordal Plate | 1931 neurenteric canal

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Scanning EM

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development

Kyoto Collection

View: embryonic disc, showing the epiblast viewed from the amniotic (dorsal) side. Amniotic membrane removed, connecting stalk to the left.

Image source: Embryology page Created: 19.03.1999

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Dorsal view. Primitive node appears as a conspicuous opaque region with the notochordal process extending rostrally.

Ventral view. Notochordal plate visible.

iBook - Carnegie Embryos

iTunes link | iBook Store Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology. Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English. PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning). The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Serial Sections

Notochordal process and notochordal canal. (detail) Primitive pit. (detail) Primitive groove and primitive streak. (detail)

Prechordal plate. Neural groove. Notochordal process and notochordal canal. Primitive pit. Primitive groove and primitive streak.

Hill Collection

"Dobbin" Embryo
Further descriptions of the "Dobbin" Embryo characterised as (Carnegie Stage 8) can be found in the following papers: Hill JP. and Florian J. The development of head-process and prochordal plate in man (1931) J Anat. 65(2): 242-6. PMID 17104317 Hill JP. and Florian J. A young human embryo (embryo dobbin) with head-process and prochordal plate. (1931) Phil. Tran. Roy. Soc. London B, 219: 443-486. Hill JP. and Florian J. Further note on the pro-chordal plate in man. (1931) J. Anat., 46: 46-47. PMID 17104356
Note the rostral end of notochordal process was at first mistaken for prechordal plate, see published correction. See page - Carnegie Stage 8 - "Dobbin" Embryo Stage 8 Links: Week 3 | Gastrulation | Lecture | Lecture | Somitogenesis | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Science Practical | Carnegie Embryos | Category:Carnegie Stage 8 | Next Stage 9   Historic Papers: 1920 Mateer Embryo | 1931 Head-Process | 1931 Prochordal Plate | 1931 neurenteric canal

chorionic vesicle stereo view 1	chorionic vesicle stereo view 2
embryo stereo view 1	embryo stereo view 2

Image source: The images from the Hill Collection (part of the Embryological Collection) are reproduced with the permission of the Museum für Naturkunde, Leibniz Institute for Research on Evolution and Biodiversity. Images are for educational purposes only and must not be reproduced electronically or in writing without permission from the Museum für Naturkunde Berlin.

Links: Hill Collection

This Embryology category shows pages and media related to Carnegie stage 8 of embryonic development that occurs during Week 3 (post-fertilisation) or gestational age, GA, LMP week 5.

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Carnegie Collection - Stage 8
Serial No.	Grade	Fixative	Embedding Medium	Plane	Thinness (µm)	Stain	Year	Notes
1399	Poor	Formol	P	Transverse	10	(Stain - Haematoxylin Eosin) etc.	1916	"Mateer embryo" described by Streeter (1920a)
3412	Poor	Formol	P	Transverse	5-15	Al. coch. E. au., or.	1921
5960	Good	Kaiserling	P	Transverse	5	Al. coch. & eosin	1929	Heuser (1932b)
6630	Poor	Formol	P	Oblique	6	(Stain - Haematoxylin Eosin)	1932
6815	Poor	Formol	P	Oblique	10	Al. coch., or. G	1933
7170a and b 7545	Poor	Alc.	C-P	Transverse	6	(Stain - Haematoxylin Eosin)	1935	Twins
7568	Poor	Formoi	C-P	Transverse	6	(Stain - Haematoxylin Eosin)	1938
7640	Good	Formol & Bouin	P	Transverse	10	(Stain - Haematoxylin Eosin)	1939	George (1942)
7666	Exc.	Formol-chrom. subl.	C-P	Transverse	6	(Stain - Haematoxylin Eosin)	1939	"H. 1515"
7701	Exc.	?	C-P	Transverse	8	(Stain - Haematoxylin Eosin)	1939
7822	Good	Formoi	C-P	Transverse	10	(Stain - Haematoxylin Eosin)	1940
7949	Good	Zenker	p	Sagittal	10	(Stain - Haematoxylin Eosin) etc.	1941
7972	Good	Alc. & Bouin	C-P	Sagittal	6	(Stain - Haematoxylin Eosin)	1942
8255	Exc.	Bouin	C-P	Sagittal	8	(Stain - Haematoxylin Eosin), phlox.	1944	Slides showing embryo returned to Dr. Patten in 1962
8320	Good	Formol	C-P	Sagittal	8	(Stain - Haematoxylin Eosin), phlox.	1945
8352	Good	Formol	C-P	Transverse	8	(Stain - Haematoxylin Eosin), phlox.	1946
8371	Poor	Alc. & Bouin	C-P	Sagittal	8	(Stain - Haematoxylin Eosin), phlox.	1946
8671	Exc.	Alc. & Bouin	C-P	Sagittal	6	(Stain - Haematoxylin Eosin), phlox.	1949
8725	Exc.	Alc. & Bouin	C-P	Sagittal	6	(Stain - Haematoxylin Eosin), phlox.	1949	Preparation method described by Heard (1957)
8727	Exc.	Alc. & Bouin	C-P	Transverse	8	(Stain - Haematoxylin Eosin), phlox.	1949	Germ disc folded, possibly double (Hertig, 1968, fig. 180)
8820	Good	Zenker-formol	?	Transverse	10	(Stain - Haematoxylin Eosin)	1951	"Jones-Brewer I" (H. 1459) described by Jones and Brewer (1941)
9009a and b 9123	Good	Formol	C-P	Sagittal	6	(Stain - Haematoxylin Eosin)	1952	Twins described briefly by Heuser (1954)
8371	Good	Formol	C-P	Sagittal	6	(Stain - Haematoxylin Eosin)	1953
9251	Good	?	C-P	Sagittal	10-12	Azan, H. & phlox.	1954
9286	Exc.	Formol	C-P	Transverse	8	Azan	1955
10157	Exc.	Formol	C-P	Transverse	?	Cason	1967
10174	Exc.	Bouin	p	Transverse	8	Cason	1967
Abbreviations Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections. Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P). Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution) ? - unknown or not determined.
References

An historic example of this stage is shown by the Dobbin embryo, described in detail by the series of papers by Hill and Florian (1931a,b,c). Abortion. Chorion, 11.5 x 8.5 x 4.5 mm. Chorionic cavity, 9 x 5.5 x 2.5 mm. Embryonic disc (narrow type), 0.96 x 0.41 mm. Primitive streak, 0.42 mm to notopore. Notochordal process, 0.42 mm. Notochordal canal communicates with cavity of umbilical vesicle by seven openings, the caudalmost of which is the ventral opening of a very short neurenteric canal. Prechordal plate, 0.03 mm; rostral end of notochordal process was at first mistaken for prechordal plate.

Other Embryo Examples

Based on O'Rahilly, R. and Müller (1987) and listed in order of length of notochordal process.

• Pha XVII. Chorionic cavity, 3.317 x 2.79 x 0.714mm. Embryonic disc, 0.412 mm. This embryo is said to resemble No. 7802 (stage 7). In addition to a notochordal process (Mazanec, 1959., fig. 104) of 0.01 mm, however, it is thought to show probably the Anlage of the notochordal canal and an unusually large prechordal plate. Possible primordial germ cells were seen in the wall of the umbilical vesicle. Presumed age, 16-17 days. Median projection published (ibid., fig. 44).
• Carnegie No. 8820, Jones-Brewer I. Described by Jones and Brewer (1941). Hysterectomy. Chorionic cavity, 6 x 5 x 2.5 mm. Embryonic disc (broad type), 0.58 x 0.78 mm (in straight line); 0.6 x 0.79 mm (over curve). Primitive streak, 0.22 mm. Primitive node (0.06 mm) situated somewhat rostral to midpoint of embryonic disc. Three small, discontinuous cavities in node “represent the beginning of a neurenteric canal” which has no dorsal opening and does not communicate with the umbilical vesicle. Notochordal process, 0.0414 mm, but with no canalization. Hemocytoblasts and primitive erythroblasts identified in wall of umbilical vesicle (Bloom and Bartelmez, 1940). Presumed age, 18½ days. Dorsal and median projections published (Jones and Brewer, 1941, figs. 11 and 12; Mazanec, 1959, fig. 48).
• Carnegie No. 9286 Embryonic disc, 1.13 x 0.77 mm. Primitive streak, 0.38 mm. Notochordal process, 0.15 mm. An excellent specimen reconstructed by O'Rahilly and Müller (1981, fig. 3), who give details of ten other Carnegie specimens
• Carnegie No. 9009. Described briefly in an abstract by Heuser (1954). Hysterectomy. Monozygotic twin embryos. Embryonic discs, 0.9 and 0.66 mm. In each: primitive node in middle of disc, notochordal process with first evidence of canalization. Notochordal processes, 0.16 and 0.07 mm. Assigned to horizon VIII by Heuser, who estimated the age as 17 days. Reconstructed by O’Rahilly and Müller (1981, fig. 2B,C).
• Shaw. Described by Gladstone and Hamilton (1941). Hysterectomy. Chorion, 11 x 4.04 mm. Chorionic cavity, 8 x 3 mm. Embryonic disc (broad type), 1.05 x 1.34 mm. Notochordal process, 0.17 mm. Primitive pit and notochordal canal (which does not open into the umbilical vesicle). Prechordal plate identified but doubted by Mazanec (1959). No neural groove. Possible amniotic duct. Hemopoiesis (hemocytoblasts and primitive erythroblasts) under way in wall of umbilical vesicle and in connecting stalk. Chorionic villi and endometrium described by Hamilton and Gladstone (1942); trophoblast further described by Hamilton and Boyd (1960). Presumed age, 18 days. Median projection published (Gladstone and Hamilton, 1941; Mazanec, 1959, fig. 58).
• Wa 17 (Wagner). Described by Grosser (1931a,b). Hysterectomy. Chorionic cavity, 8.5 x 8.5 x 7.5 mm. Embryonic disc (narrow type), 0.98 x 0.7 mm. Primitive streak, 0.5 mm. Notochordal process, 0.18 mm. Possible dorsal and ventral openings of the notochordal canal. Prechordal plate, 0.075 mm. Presumed age, about 19 days. Dorsal and median projections published (Grosser, 1931a, figs. 4 and 3; Hill and Florian, 1931b, fig. 7; Mazanec, 1959, fig. 59).
• Carnegie No. 8671. Low-power photomicrographs reproduced by Hertig (1968, figs. 47 and 181). Notochordal process, 0.23 mm.
• Kl. 13. Described by Grosser (1913). Traumatic abortion following salpingo-oophorectomy. Chorionic cavity, 8 x 6 mm. Embryonic disc, 0.67 x 0.5 mm. Primitive streak, 0.27 mm. Notochordal process, 0.2 mm. Notochordal canal, 0.25 mm (Florian, 1934c) with dorsal pit and ventral opening: notochordal plate intercalated in endoderm. Possible prechordal plate. Presumed age, about 18 days. Median projection published (Grosser, 1913, plate 27, fig. 4; Mazanec, 1959, fig. 62). Compared with other specimens by Grosser (1934).
• HEB-42. Described by Mazanec and Musilovà (1959). Curettage. Embryonic disc, 1.17 x 0.72 mm; 1.43 mm by flexible scale. Primitive streak, 0.54 mm. Primitive node, 0.06 mm. Primitive pit. Notochordal process, 0.25 mm. Small cavity (primordium of notochordal canal) in notochordal process. Prechordal plate not mentioned. Presumed age, 17-18 days. Dorsal and median projections published (ibid., figs. 1 and 2).
• Dy (Dyhrenfurth). Described by Triepel (1916). Abortion. Embryonic disc, 1.6 x 1.04 mm. Primitive streak, 0.11 mm. Notochordal process and plate, 0.3 mm. Primitive pit, neurenteric canal, and neural groove believed to be present. Anlagen of hypophysis and optic vesicles claimed unconvincingly (plane of section unsuitable). Embryonic disc bent ventrally through a right angle (normality of specimen questioned). First somite probably not present.
• 23 Somites Thompson and Brash (1923) described a hysterectomy specimen that showed a chorionic cavity of 10 x 7.5 x 4 mm. Embryonic disc (broad type), 0.68 x 0.9 mm. Primitive streak and groove present. Notochordal process, 0.3 mm, with no distinct lumen but notochordal canal about to appear. Mazanec (1959) considered that, on the basis of the reconstruction, the notochordal process could not be more than 0.23 mm. Definite prechordal plate (Hill and Florian, 1931b). Rough dorsal and median drawings included (Thompson and Brash, 1923, figs, 2 and 3) and median projection published (Mazanec, 1959, fig. 55). This embryo belongs either to stage 7 or to stage 8.
• Schö (Schönholz). Described by Waldeyer (1929a,b) Hysterectomy. Embryonic disc, 0.99 x 1.03 x 0.11 mm. Primitive streak, 0.51 mm, and node. Primitive groove and pit: “indentation” is perhaps “first Anlage of [notochordal] canal.” Notochordal process, 0.34 mm. Prechordal plate. Said to lie between Hugo (stage 7) and Peh. l-Hochstetter (stage 8). Dorsal and median projections published (ibid., figs. 6 and 5; Hill and Florian, 1931b, figs. 6 and 14; Mazanec, 1959, fig. 57).
• Dobbin. Important specimen described in detail by Hill and Florian (1931a,b,c). Abortion. Chorion, 11.5 x 8.5 x 4.5 mm. Chorionic cavity, 9 x 5.5 x 2.5 mm. Embryonic disc (narrow type), 0.96 x 0.41 mm. Primitive streak, 0.42 mm to notopore. Notochordal process, 0.42 mm. Notochordal canal communicates with cavity of umbilical vesicle by seven openings, the caudalmost of which is the ventral opening of a very short neurenteric canal. Prechordal plate, 0.03 mm; rostral end of notochordal process was at first mistaken for prechordal plate. Dorsal and median projections published (Hill and Florian, 1931b, figs. 1 and 2; Mazanec, 1959, fig. 60). The scale in fig. 3 of Hill and Florian (1931b) is incorrect (Florian, 1934c). Specimen is now housed in Hubrecht Laboratory, Utrecht (No. H91; HH 159).
• Carnegie No. 5960 Important specimen described by Heuser (1932b). Hysterectomy. Chorion, 15 x 14 x 9 mm. Embryonic disc (narrow type), 1.25 x 0.68 mm (in straight line); 1.53 x 0.75 mm (by flexible scale). Primitive streak, 0.5 (0.44?) mm. Primitive node, 0.2 (0.06?) mm, slightly caudal to midpoint of embryonic disc. Notochordal process, 0.42 mm (George, 1942). Notochordal canal (about 0.4 mm) opens ventrally. Prechordal plate, 0.15 mm. Florian (1934b), however, believed that the prechordal plate was situated further rostrally than shown by Heuser. Angiogenesis in umbilical vesicle, body stalk, and chorion. Angiogenesis in chorion described by Hertig (1935). Neural groove. Presumed age, 18 days. Dorsal and median projections published (Heuser, 1932b, figs. 33 and 47; Mazanec, 1959, fig. 63).
• Carnegie No. 7545. Embryonic disc, 1.52 x 1.03 mm. Primitive streak, 0.61 mm. Notochordal process, 0.43 mm. Reconstructed by O'Rahilly and Müller (1981, fig. 2E).
• Carnegie No. 7640. Described by George (1942). Tubal. Embryonic disc (broad type), 1.01 x 0.83 mm (in straight line); 1.16 mm by flexible scale. Primitive streak, node, and pit present. Notochordal process, 0.44 mm. Notochordal canal continuous with primitive pit; floor of canal has disappeared in its middle quarter. Prechordal plate, 0.12 mm, said to contain continuation of notochordal canal. Neural groove. Dorsal and median projections published (ibid., figs. 1 and 2).
• Peh. 1-Hochstetter (Peham). Described by Rossenbeck (1923). Chorion, 10 x 7.7 mm. Chorionic cavity, 6.8 x 5.3 mm. Embryonic disc (broad type; this might be disputed, however), 1.77 (Florian, 1934) x 1 mm. Primitive streak, 0.69 mm. Notochordal process (Mazanec, 1959, figs. 107 and 108), 0.6 mm. Notochordal canal ready to break through into umbilical vesicle in one section. Prechordal plate (confirmed by Florian, 1931), 0.08 mm. Indication of hindgut (Florian, 1934b). Allanto-enteric diverticulum (Florian, 1930a). Dorsal and median projections published (Hill and Florian, 1931b, figs. 9 and 16; Mazanec, 1959, fig. 61).
• R. S. (Robb Smith). Described by Odgers (1941). Hysterectomy. Embryonic disc (broad type), 1.5 x 1.36 mm. Primitive streak, 0.4 mm. Notochordal plate (intercalated in endoderm), 0.7 mm. Neurenteric canal extends vertically from amniotic cavity to umbilical vesicle. Prechordal plate, 0.29 mm, containing perhaps remains of notochordal canal. Commencing neural groove. Dorsal and median projections published (ibid., figs. 1 and 2).
• Western Reserve No. 1. Described by Ingalls (1918). Abortion. Chorion, 9.1 x 8.2 x 6.5 mm. Chorionic cavity, 8 x 7 x 5 mm. Embryonic disc (narrow type), 2 (1.87?) x 0.75 mm. Primitive streak, 0.67 mm. Primitive pit present. Notochordal process, 0.75 (0.65?), Hill and Florian, 1931b) mm. Notochordal canal, 0.34 mm, with three ventral openings into umbilical vesicle. Prechordal plate identified (but not 0.4 mm in length, according to Mazanec, 1959). Dorsal and median projections published (Hill and Florian, 1931b, figs. 10 and 17; Mazanec, 1959, fig. 64).

Precise measurements of the notochordal process have not been provided in the accounts of the following embryos.

• M’lntyre. Described by Bryce (1924) and M’Intyre (1926). Hysterectomy. Chorion, 14 x 13 x 8 mm. Embryonic disc, 1.37 x 0.5 mm. Primitive streak, 0.32 mm. Notochordal plate, neurenteric canal, and prechordal plate (with cavity) present. Neural groove, future foregut, U-shaped pericardial cavity, and “some general resemblance to somites” noted. Rough dorsal and median drawings included (Bryce, 1924, figs. 5 and 49). May belong to stage 9.
• Frassi’s specimen (Keibel, 1907; Frassi, 1908) was illustrated as Normentafel No. 1 by Keibel and Elze (1908). Embryonic disc, 1.17 x 0.6 mm. Primitive streak and neurenteric canal identified. Neural groove. No somites.
• Gle., or Gläveke (von Spee, 1889 and 1896). Illustrated as Normentafel No. 2 by Keibel and Elze (1908). See also Kollmann (1907) and Keibel and Mall (1910, 1912). Chorion, 6 x 4.5 mm. Chorionic cavity, 5.3 x 3.8 mm. Embryonic disc, 1.54 mm. Primitive streak and node, notochordal plate, and neurenteric canal (Van Beneden, 1899) identified (Keibel and Mall, 1912, fig. 231). Neural groove. Indication of foregut and pericardial cavities. Anlage of endocardium. No somites detected, although a small cavity on the left side (Keibel and Elze, 1908, fig. 4f) could be considered as the first Anlage of a myocoele. May belong to stage 9.
• Strahl (1916) described briefly a specimen that possessed a notochordal process and canal, and apparently a prechordal plate. A median drawing was included (ibid., fig. a) but measurements were not provided.
• Vuill., or Vulliet. Illustrated schematically by Eternod (1899a and 1909), Kollmann (1907), and Keibel and Mall (1912). Chorion, 10 x 8.2 x 6 mm. Chorionic cavity, 9 x 7.2 x 5 mm. Embryonic disc, 1.3 mm. Notochordal and neurenteric canals (Eternod, 1899b).
• Cordier and Coujard (1939) described an embryo of 1.05 mm showing a neural groove and folds, notochordal canal, primordial germ cells, but no somites, no intra-embryonic coelom, and no cardiac rudiment.
• Carnegie No. 8727. Photomicrograph reproduced by Hertig (1968, fig. 180). The partial duplication of the embryonic disc shown in this specimen would presumably have resulted in conjoined twins.

Certain other embryos that probably belong to stage 8.

• Krukenberg (1922) and Fitzgerald- Brewer I (Brewer and Fitzgerald, 1937).
• Boerner-Patzelt and Schwarzacher (1923) described an unsatisfactory specimen (embryonic disc, 0.47 x 0.43 mm) that showed a neurenteric canal,
• Broman (1936) described in detail an abnormal specimen (“Lqt”) in which the primitive streak showed “overgrowth” in relation to the neurenteric canal, resulting in a dislocation within the embryonic disc.

Additional Images

Historic Images

• 

  Human 2 mm embryo dorsal view neural plate

• 

  Dorsal view of Carnegie embryo No. 5960.

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

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Cite this page: Hill, M.A. (2023, December 5) Embryology Carnegie stage 8. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_8

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