Abnormal Development - Hypertension
|Embryology - 4 Jul 2020 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
|Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.|
Hypertensive disorders of pregnancy (maternal hypertension) can be environmental, genetic or of unknown causes, occurs in 2-3% (some say higher) of all pregnancies and has an increasing incidence associated with obesity. This page mainly focusses on the effects of hypertension on development, rather than the maternal health condition. Pregnancy-induced hypertension is defined as systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg.
Hypertension has previously been grouped into 4 classes:
- chronic hypertension
- preeclampsia superimposed on chronic hypertension
- gestational hypertension (transient hypertension of pregnancy , chronic hypertension after GA 20 weeks)
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.|
Gestational hypertension was previously called pregnancy-induced hypertension (PIH) and is the new onset of hypertension after 20 weeks of gestation.
This condition is also known as gestational proteinuric hypertension and occurs in occurs in approximately 2 to 4% of all pregnancies. The pathogenesis of eclamptic convulsions remains unknown and women with a history of eclampsia are at increased risk of eclampsia (1-2%) and preeclampsia (22-35%) in subsequent pregnancies. "Magnesium sulfate is the drug of choice for reducing the rate of eclampsia developing intrapartum and immediately postpartum."(see Sibai BM. 2005).
Recent research using a large population study in Norway has shown a strong generational association such that daughters of women who had pre-eclampsia during pregnancy had more than twice the risk of pre-eclampsia themselves. The paper concludes "Maternal genes and fetal genes from either the mother or father may trigger pre-eclampsia. The maternal association is stronger than the fetal association. The familial association predicts more severe pre-eclampsia."
- Kintiraki E, Papakatsika S, Kotronis G, Goulis DG & Kotsis V. (2015). Pregnancy-Induced hypertension. Hormones (Athens) , 14, 211-23. PMID: 26158653 DOI.
- Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030
- Agopian AJ, Hoang TT, Mitchell LE, Morrison AC, Tu D, Nassar N & Canfield MA. (2016). Maternal hypertension and risk for hypospadias in offspring. Am. J. Med. Genet. A , 170, 3125-3132. PMID: 27570224 DOI.
- Booker WA, Ananth CV, Wright JD, Siddiq Z, D'Alton ME, Cleary KL, Goffman D & Friedman AM. (2019). Trends in comorbidity, acuity, and maternal risk associated with preeclampsia across obstetric volume settings. J. Matern. Fetal. Neonatal. Med. , 32, 2680-2687. PMID: 29478359 DOI.
- Luizon MR, Pereira DA & Sandrim VC. (2018). Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions. Front Pharmacol , 9, 168. PMID: 29541029 DOI.
- Skjaerven R, Vatten LJ, Wilcox AJ, Rønning T, Irgens LM & Lie RT. (2005). Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ , 331, 877. PMID: 16169871 DOI.
Leeman L & Fontaine P. (2008). Hypertensive disorders of pregnancy. Am Fam Physician , 78, 93-100. PMID: 18649616
Ahmad AS & Samuelsen SO. (2012). Hypertensive disorders in pregnancy and fetal death at different gestational lengths: a population study of 2 121 371 pregnancies. BJOG , 119, 1521-8. PMID: 22925135 DOI.
Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Medline Plus -
- American Congress of Obstetricians and Gynecologists - 2013 Report - Hypertension in Pregnancy
- Journal - Hypertension
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2020, July 4) Embryology Abnormal Development - Hypertension. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Hypertension
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G