Abnormal Development - Hypertension

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Introduction

Hypertensive disorders of pregnancy (maternal hypertension) can be environmental, genetic or of unknown causes, occurs in 2-3% (some say higher) of all pregnancies and has an increasing incidence associated with obesity. This page mainly focusses on the effects of hypertension on development, rather than the maternal health condition.

Hypertension has previously been grouped into 4 classes:[1]

  1. chronic hypertension
  2. preeclampsia-eclampsia
  3. preeclampsia superimposed on chronic hypertension
  4. gestational hypertension (transient hypertension of pregnancy , chronic hypertension after GA 20 weeks)


Draft Page - Notice removed when completed.


Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis

Some Recent Findings

  • Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions[2] "Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients."
More recent papers  
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  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
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Search term: Maternal Hypertension

X Y Guo, H Shao, Y Y Zhao [A case of systemic lupus erythematosus in pregnancy complicated by pulmonary hypertension]. Beijing Da Xue Xue Bao: 2018, 50(5);928-931 PubMed 30337761

Regina A Nascimento, José S Possomato-Vieira, Victor H Gonçalves-Rizzi, Gisele F Bonacio, Elen Rizzi, Carlos A Dias-Junior Hypertension, augmented activity of matrix metalloproteinases-2 and -9 and angiogenic imbalance in hypertensive pregnancy are attenuated by doxycycline. Eur. J. Pharmacol.: 2018; PubMed 30336141

Ahmed M Hasanin, Sarah M Amin, Nora A Agiza, Mohamed K Elsayed, Sherin Refaat, Hazem A Hussein, Tamer I Rouk, Mostafa Alrahmany, Mohamed E Elsayad, Khaled A Elshafaei, Amira Refaie Norepinephrine Infusion for Preventing Postspinal Anesthesia Hypotension during Cesarean Delivery: A Randomized Dose-finding Trial. Anesthesiology: 2018; PubMed 30335625

X Gong, A Liu, Y Li, H Sun, Y Li, C Li, X Yu, C Fan, Z Shan, W Teng The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China. J. Endocrinol. Invest.: 2018; PubMed 30334197

Fouzia Khanam, Belal Hossain, Sabuj Kanti Mistry, Dipak K Mitra, Wameq Azfar Raza, Mahfuza Rifat, Kaosar Afsana, Mahfuzar Rahman The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh. BMC Pregnancy Childbirth: 2018, 18(1);406 PubMed 30332997


Search term: Gestational Hypertension

Margie H Davenport, Stephanie-May Ruchat, Veronica J Poitras, Alejandra Jaramillo Garcia, Casey E Gray, Nick Barrowman, Rachel J Skow, Victoria L Meah, Laurel Riske, Frances Sobierajski, Marina James, Amariah J Kathol, Megan Nuspl, Andree-Anne Marchand, Taniya S Nagpal, Linda G Slater, Ashley Weeks, Kristi B Adamo, Gregory A Davies, Ruben Barakat, Michelle F Mottola Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis. Br J Sports Med: 2018, 52(21);1367-1375 PubMed 30337463

Regina A Nascimento, José S Possomato-Vieira, Victor H Gonçalves-Rizzi, Gisele F Bonacio, Elen Rizzi, Carlos A Dias-Junior Hypertension, augmented activity of matrix metalloproteinases-2 and -9 and angiogenic imbalance in hypertensive pregnancy are attenuated by doxycycline. Eur. J. Pharmacol.: 2018; PubMed 30336141

X Gong, A Liu, Y Li, H Sun, Y Li, C Li, X Yu, C Fan, Z Shan, W Teng The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China. J. Endocrinol. Invest.: 2018; PubMed 30334197

Fouzia Khanam, Belal Hossain, Sabuj Kanti Mistry, Dipak K Mitra, Wameq Azfar Raza, Mahfuza Rifat, Kaosar Afsana, Mahfuzar Rahman The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh. BMC Pregnancy Childbirth: 2018, 18(1);406 PubMed 30332997

Barbara Luke, Morton B Brown, Ethan Wantman, David B Seifer, Amy T Sparks, Paul C Lin, Kevin J Doody, Bradley J Van Voorhis, Logan G Spector Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality. J. Assist. Reprod. Genet.: 2018; PubMed 30328574


Search term: Preeclampsia

Wentao Yu, Wei Gao, Dan Rong, Zhixian Wu, Raouf A Khalil Molecular Determinants of Microvascular Dysfunction in Hypertensive Pregnancy and Preeclampsia. Microcirculation: 2018;e12508 PubMed 30338879

C-X Lou, X-T Zhou, Q-C Tian, H-Q Xie, J-Y Zhang Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN. Eur Rev Med Pharmacol Sci: 2018, 22(19);6181-6189 PubMed 30338782

Z-M Zhao, J Jiang Lowly expressed EGFR-AS1 promotes the progression of preeclampsia by inhibiting the EGFR-JAK/STAT signaling pathway. Eur Rev Med Pharmacol Sci: 2018, 22(19);6190-6197 PubMed 30338781

Margie H Davenport, Stephanie-May Ruchat, Veronica J Poitras, Alejandra Jaramillo Garcia, Casey E Gray, Nick Barrowman, Rachel J Skow, Victoria L Meah, Laurel Riske, Frances Sobierajski, Marina James, Amariah J Kathol, Megan Nuspl, Andree-Anne Marchand, Taniya S Nagpal, Linda G Slater, Ashley Weeks, Kristi B Adamo, Gregory A Davies, Ruben Barakat, Michelle F Mottola Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis. Br J Sports Med: 2018, 52(21);1367-1375 PubMed 30337463

David Rodriguez, Gerardo Garcia-Rivas, Estibalitz Laresgoiti-Servitje, Jesus Yañez, Guillermo Torre-Amione, Carlos Jerjes-Sanchez B-type natriuretic peptide reference interval of newborns from healthy and pre-eclamptic women: a prospective, multicentre, cross-sectional study. BMJ Open: 2018, 8(10);e022562 PubMed 30337314

Gestational Hypertension

Gestational hypertension was previously called pregnancy-induced hypertension (PIH) and is the new onset of hypertension after 20 weeks of gestation.


Pre-Eclampsia

This condition is also known as gestational proteinuric hypertension and occurs in occurs in approximately 2 to 4% of all pregnancies. The pathogenesis of eclamptic convulsions remains unknown and women with a history of eclampsia are at increased risk of eclampsia (1-2%) and preeclampsia (22-35%) in subsequent pregnancies. "Magnesium sulfate is the drug of choice for reducing the rate of eclampsia developing intrapartum and immediately postpartum."(see Sibai BM. 2005).

Recent research using a large population study in Norway has shown a strong generational association such that daughters of women who had pre-eclampsia during pregnancy had more than twice the risk of pre-eclampsia themselves. The paper concludes "Maternal genes and fetal genes from either the mother or father may trigger pre-eclampsia. The maternal association is stronger than the fetal association. The familial association predicts more severe pre-eclampsia."[3]

References

  1. Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030
  2. Luizon MR, Pereira DA & Sandrim VC. (2018). Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions. Front Pharmacol , 9, 168. PMID: 29541029 DOI.
  3. Skjaerven R, Vatten LJ, Wilcox AJ, Rønning T, Irgens LM & Lie RT. (2005). Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ , 331, 877. PMID: 16169871 DOI.

Reviews

Hutcheon JA, Lisonkova S & Joseph KS. (2011). Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol , 25, 391-403. PMID: 21333604 DOI.

Leeman L & Fontaine P. (2008). Hypertensive disorders of pregnancy. Am Fam Physician , 78, 93-100. PMID: 18649616

Articles

Ahmad AS & Samuelsen SO. (2012). Hypertensive disorders in pregnancy and fetal death at different gestational lengths: a population study of 2 121 371 pregnancies. BJOG , 119, 1521-8. PMID: 22925135 DOI.

Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030


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Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis


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Cite this page: Hill, M.A. (2018, October 20) Embryology Abnormal Development - Hypertension. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Hypertension

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G