Abnormal Development - Hypertension

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Introduction

Hypertensive disorders of pregnancy (maternal hypertension) can be environmental, genetic or of unknown causes, occurs in 2-3% (some say higher) of all pregnancies and has an increasing incidence associated with obesity. This page mainly focusses on the effects of hypertension on development, rather than the maternal health condition.

Hypertension has previously been grouped into 4 classes:[1]

  1. chronic hypertension
  2. preeclampsia-eclampsia
  3. preeclampsia superimposed on chronic hypertension
  4. gestational hypertension (transient hypertension of pregnancy , chronic hypertension after GA 20 weeks)


Draft Page - Notice removed when completed.


Environmental Links: Introduction | Low Folic Acid | Iodine Deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis

Some Recent Findings

  • Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions[2] "Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients."
More recent papers  
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Search term: Maternal Hypertension

Esme I Kamphuis, Anita C J Ravelli, Bouchra Koullali, Brenda Kazemier, Christianne J M de Groot, Ben Willem J Mol Spontaneous and iatrogenic preterm birth rates among unselected women in three consecutive pregnancies. Eur. J. Obstet. Gynecol. Reprod. Biol.: 2018, 228;92-97 PubMed 29913333

Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman Low dose aspirin is associated with reduced spontaneous preterm birth in nulliparous women. Am. J. Obstet. Gynecol.: 2018; PubMed 29913174

Mary F Feitosa, Aldi T Kraja, Daniel I Chasman, Yun J Sung, Thomas W Winkler, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K Musani, Changwei Li, Amy R Bentley, Michael R Brown, Karen Schwander, Melissa A Richard, Raymond Noordam, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Rajkumar Dorajoo, Virginia Fisher, Fernando P Hartwig, Andrea R V R Horimoto, Kurt K Lohman, Alisa K Manning, Tuomo Rankinen, Albert V Smith, Salman M Tajuddin, Mary K Wojczynski, Maris Alver, Mathilde Boissel, Qiuyin Cai, Archie Campbell, Jin Fang Chai, Xu Chen, Jasmin Divers, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E Harris, Meian He, Fang-Chi Hsu, Anne U Jackson, Mika Kähönen, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Federica Laguzzi, Jian'an Luan, Nana Matoba, Ilja M Nolte, Sandosh Padmanabhan, Muhammad Riaz, Rico Rueedi, Antonietta Robino, M Abdullah Said, Robert A Scott, Tamar Sofer, Alena Stančáková, Fumihiko Takeuchi, Bamidele O Tayo, Peter J van der Most, Tibor V Varga, Veronique Vitart, Yajuan Wang, Erin B Ware, Helen R Warren, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E Arking, Tin Aung, Eric Boerwinkle, Ingrid Borecki, Ulrich Broeckel, Morris Brown, Marco Brumat, Gregory L Burke, Mickaël Canouil, Aravinda Chakravarti, Sabanayagam Charumathi, Yii-Der Ida Chen, John M Connell, Adolfo Correa, Lisa de Las Fuentes, Renée de Mutsert, H Janaka de Silva, Xuan Deng, Jingzhong Ding, Qing Duan, Charles B Eaton, Georg Ehret, Ruben N Eppinga, Evangelos Evangelou, Jessica D Faul, Stephan B Felix, Nita G Forouhi, Terrence Forrester, Oscar H Franco, Yechiel Friedlander, Ilaria Gandin, He Gao, Mohsen Ghanbari, Bruna Gigante, C Charles Gu, Dongfeng Gu, Saskia P Hagenaars, Göran Hallmans, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Barbara V Howard, M Arfan Ikram, InterAct Consortium, Ulrich John, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, José E Krieger, Stephen B Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A Lakka, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Benjamin Lehne, Cora E Lewis, Yize Li, Shiow Lin, Jianjun Liu, Jingmin Liu, Marie Loh, Tin Louie, Reedik Mägi, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L Mohlke, Yukihide Momozawa, Mike A Nalls, Christopher P Nelson, Nona Sotoodehnia, Jill M Norris, Jeff R O'Connell, Nicholette D Palmer, Thomas Perls, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Neil Poulter, Leslie J Raffel, Olli T Raitakari, Kathryn Roll, Lynda M Rose, Frits R Rosendaal, Jerome I Rotter, Carsten O Schmidt, Pamela J Schreiner, Nicole Schupf, William R Scott, Peter S Sever, Yuan Shi, Stephen Sidney, Mario Sims, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, John M Starr, Konstantin Strauch, Heather M Stringham, Nicholas Y Q Tan, Hua Tang, Kent D Taylor, Yik Ying Teo, Yih Chung Tham, Stephen T Turner, André G Uitterlinden, Peter Vollenweider, Melanie Waldenberger, Lihua Wang, Ya Xing Wang, Wen Bin Wei, Christine Williams, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, John C Chambers, Ian J Deary, Tõnu Esko, Martin Farrall, Paul W Franks, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Yoichiro Kamatani, Norihiro Kato, Jaspal S Kooner, Zoltán Kutalik, Markku Laakso, Cathy C Laurie, Karin Leander, Terho Lehtimäki, Lifelines Cohort Study, Patrik K E Magnusson, Albertine J Oldehinkel, Brenda W J H Penninx, Ozren Polasek, David J Porteous, Rainer Rauramaa, Nilesh J Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E Wagenknecht, Nicholas J Wareham, Hugh Watkins, David R Weir, Ananda R Wickremasinghe, Tangchun Wu, Wei Zheng, Claude Bouchard, Kaare Christensen, Michele K Evans, Vilmundur Gudnason, Bernardo L Horta, Sharon L R Kardia, Yongmei Liu, Alexandre C Pereira, Bruce M Psaty, Paul M Ridker, Rob M van Dam, W James Gauderman, Xiaofeng Zhu, Dennis O Mook-Kanamori, Myriam Fornage, Charles N Rotimi, L Adrienne Cupples, Tanika N Kelly, Ervin R Fox, Caroline Hayward, Cornelia M van Duijn, E Shyong Tai, Tien Yin Wong, Charles Kooperberg, Walter Palmas, Kenneth Rice, Alanna C Morrison, Paul Elliott, Mark J Caulfield, Patricia B Munroe, Dabeeru C Rao, Michael A Province, Daniel Levy Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE: 2018, 13(6);e0198166 PubMed 29912962

Linn Håkonsen Arendt, Tine Brink Henriksen, Morten Søndergaard Lindhard, Erik T Parner, Jørn Olsen, Cecilia Høst Ramlau-Hansen Hypertensive Disorders of Pregnancy and Genital Anomalies in Boys: A Danish Nationwide Cohort Study. Epidemiology: 2018; PubMed 29912017

N Martell Claros [Gestational hypertension]. [La hipertensión arterial en la embarazada.] Hipertens Riesgo Vasc: 2017, 34 Suppl 2;22-25 PubMed 29908662


Search term: Gestational Hypertension

Esme I Kamphuis, Anita C J Ravelli, Bouchra Koullali, Brenda Kazemier, Christianne J M de Groot, Ben Willem J Mol Spontaneous and iatrogenic preterm birth rates among unselected women in three consecutive pregnancies. Eur. J. Obstet. Gynecol. Reprod. Biol.: 2018, 228;92-97 PubMed 29913333

Linn Håkonsen Arendt, Tine Brink Henriksen, Morten Søndergaard Lindhard, Erik T Parner, Jørn Olsen, Cecilia Høst Ramlau-Hansen Hypertensive Disorders of Pregnancy and Genital Anomalies in Boys: A Danish Nationwide Cohort Study. Epidemiology: 2018; PubMed 29912017

N Martell Claros [Gestational hypertension]. [La hipertensión arterial en la embarazada.] Hipertens Riesgo Vasc: 2017, 34 Suppl 2;22-25 PubMed 29908662

Xiu Luo, Lingfei Liu, Huaiting Gu, Fang Hou, Xinyan Xie, Xin Li, Heng Meng, Jiajia Zhang, Shunqing Xu, Ranran Song Pathways linking socioeconomic status to small-for-gestational-age (SGA) infants among primiparae: a birth cohort study in China. BMJ Open: 2018, 8(6);e020694 PubMed 29903790

Michinari Hieda, Jeung-Ki Yoo, Dan-Dan Sun, Yoshiyuki Okada, Rosemary S Parker, Monique A Roberts-Reeves, Beverley Adams-Huet, David B Nelson, Benjamin D Levine, Qi Fu Time Course of Changes in Maternal Left Ventricular Function during Subsequent Pregnancy in Women with a History of Gestational Hypertensive Disorders. Am. J. Physiol. Regul. Integr. Comp. Physiol.: 2018; PubMed 29897820


Search term: Preeclampsia

Marianna Amaral Pedroso, Kirsten Rebecca Palmer, Ryan James Hodges, Fabricio da Silva Costa, Daniel Lorber Rolnik Uterine Artery Doppler in Screening for Preeclampsia and Fetal Growth Restriction. [Doppler das artérias uterinas no rastreamento para pré-eclâmpsia e restrição do crescimento fetal.] Rev Bras Ginecol Obstet: 2018, 40(5);287-293 PubMed 29913544

Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman Low dose aspirin is associated with reduced spontaneous preterm birth in nulliparous women. Am. J. Obstet. Gynecol.: 2018; PubMed 29913174

Linn Håkonsen Arendt, Tine Brink Henriksen, Morten Søndergaard Lindhard, Erik T Parner, Jørn Olsen, Cecilia Høst Ramlau-Hansen Hypertensive Disorders of Pregnancy and Genital Anomalies in Boys: A Danish Nationwide Cohort Study. Epidemiology: 2018; PubMed 29912017

N Martell Claros [Gestational hypertension]. [La hipertensión arterial en la embarazada.] Hipertens Riesgo Vasc: 2017, 34 Suppl 2;22-25 PubMed 29908662

Roberta L Hannibal, Margarida Cardoso-Moreira, Shilpa P Chetty, Joanne Lau, Zhongxia Qi, Eduardo Gonzalez-Maldonado, Athena M Cherry, Jingwei Yu, Mary E Norton, Julie C Baker Investigating human placentation and pregnancy using first trimester chorionic villi. Placenta: 2018, 65;65-75 PubMed 29908643

Gestational Hypertension

Gestational hypertension was previously called pregnancy-induced hypertension (PIH) and is the new onset of hypertension after 20 weeks of gestation.


Pre-Eclampsia

This condition is also known as gestational proteinuric hypertension and occurs in occurs in approximately 2 to 4% of all pregnancies. The pathogenesis of eclamptic convulsions remains unknown and women with a history of eclampsia are at increased risk of eclampsia (1-2%) and preeclampsia (22-35%) in subsequent pregnancies. "Magnesium sulfate is the drug of choice for reducing the rate of eclampsia developing intrapartum and immediately postpartum."(see Sibai BM. 2005).

Recent research using a large population study in Norway has shown a strong generational association such that daughters of women who had pre-eclampsia during pregnancy had more than twice the risk of pre-eclampsia themselves. The paper concludes "Maternal genes and fetal genes from either the mother or father may trigger pre-eclampsia. The maternal association is stronger than the fetal association. The familial association predicts more severe pre-eclampsia."[3]

References

  1. Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030
  2. Luizon MR, Pereira DA & Sandrim VC. (2018). Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions. Front Pharmacol , 9, 168. PMID: 29541029 DOI.
  3. Skjaerven R, Vatten LJ, Wilcox AJ, Rønning T, Irgens LM & Lie RT. (2005). Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ , 331, 877. PMID: 16169871 DOI.

Reviews

Hutcheon JA, Lisonkova S & Joseph KS. (2011). Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol , 25, 391-403. PMID: 21333604 DOI.

Leeman L & Fontaine P. (2008). Hypertensive disorders of pregnancy. Am Fam Physician , 78, 93-100. PMID: 18649616

Articles

Ahmad AS & Samuelsen SO. (2012). Hypertensive disorders in pregnancy and fetal death at different gestational lengths: a population study of 2 121 371 pregnancies. BJOG , 119, 1521-8. PMID: 22925135 DOI.

Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M & Pedata R. (2009). Hypertensive disorders of pregnancy. J Prenat Med , 3, 1-5. PMID: 22439030


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Environmental Links: Introduction | Low Folic Acid | Iodine Deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | Zoonotic Infection | Toxoplasmosis | Malaria | Maternal Diabetes | Maternal Hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | Hypoxia | Biological Toxins | Chemicals | heavy metals | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis


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Cite this page: Hill, M.A. (2018, June 20) Embryology Abnormal Development - Hypertension. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Hypertension

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