Zebrafish Development
Introduction
Zebrafish or zebra danio (danio rerio) are seen as the latest "model' for embryological development studies. These embryos have the great advantage that they develop as "see through" embryos, that is, all internal development can be clearly observed from the outside in the living embryo. Much of the early modern work using this embryo model began with the papers of Kimmel.[1][2]
Several large laboratories in the US are now developing large breeding programs to carry out "knockouts" and to find spontaneous mutants of interest.
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Some Recent Findings
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Timeline and Stages of Embryonic Development
Duration | Period Name | Image |
0 - 0.75 hrs | Zygote Period | |
0.75 - 2.25 hrs | Cleavage Period | |
2.25 - 5.25 hrs | Blastula Period | |
5.25 - 10.33 hrs | Gastrula Period | |
10.33 - 24 hrs | Segmentation Period | |
24 - 48 hrs | Pharyngula Period | |
48-72 hrs | Hatching Period | |
72 hrs - 30 Days | Larval Period |
Molecular
Fibroblast Growth Factor
- Fgf8 and Fgf3 - regulating the segmentation of the pharyngeal endoderm into pouches. [7]
- Fgf24 and Fgf8 - promotes posterior mesodermal development.[8]
- Sox9 - required for cartilage morphogenesis.[9]
References
Reviews
<pubmed>21501748</pubmed> <pubmed>20674361</pubmed> <pubmed>19557689</pubmed> <pubmed>19371733</pubmed> <pubmed>18992377</pubmed>
Articles
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Additional Images
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- NIH NIH Zebrafish Initiative
- ZFIN - The Zebrafish Model Organism Database
- Keller at European Molecular Biology Laboratory, Germany Movies - Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
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Cite this page: Hill, M.A. (2024, May 21) Embryology Zebrafish Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Zebrafish_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G