|Embryology - 25 Sep 2018 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Movies
- 4 Zebrafish Stages
- 5 Skull
- 6 Neural
- 7 Molecular
- 8 References
- 9 Additional Images
- 10 Terms
- 11 External Links
- 12 Glossary Links
Zebrafish or zebra danio (danio rerio) are seen as one of the latest "models" for vertebrate embryological development studies. These embryos have the great advantage that they develop as "see through" embryos, that is, all internal development can be clearly observed from the outside in the living embryo. Much of the early modern work using this embryo model began with the papers of Kimmel.
Several large laboratories in the US are now developing large breeding programs to carry out "knockouts" and to find spontaneous mutants of interest.
|Fish Links: Zebrafish Development | Medaka Development | Salmon Development | Movie - Zebrafish Heart | Student Group Project - Zebrafish | Recent References | Category:Zebrafish | Category:Medaka|
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
P G Cardoso, D Rodrigues, T V Madureira, M J Rocha, E Rocha Histopathological Evaluation of Combined Impacts of the Synthetic Progestin Levonorgestrel and Temperature on the Female Zebrafish Maturation Using a Semi-quantitative Grading Analysis-Is it Enough? Bull Environ Contam Toxicol: 2018; PubMed 30187092
Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. Am. J. Hum. Genet.: 2018; PubMed 30146126
Thayres S Andrade, Rhaul de Oliveira, Muriel Lopes, Marcus Vinicius Von Zuben, Cesar Koppe Grisolia, Inês Domingues, Eloisa Dutra Caldas, Aline Pic-Taylor Exposure to ayahuasca induces to developmental and behavioral alterations on early life stages of zebrafish. Chem. Biol. Interact.: 2018; PubMed 30086270
Gaëlle J S Talhouarne, Joseph G Gall Lariat intronic RNAs in the cytoplasm of vertebrate cells. Proc. Natl. Acad. Sci. U.S.A.: 2018; PubMed 30082412
Nada D Savić, Sandra Vojnovic, Biljana Đ Glišić, Aurélien Crochet, Aleksandar Pavic, Goran V Janjić, Marina Pekmezović, Igor M Opsenica, Katharina M Fromm, Jasmina Nikodinovic-Runic, Miloš I Djuran Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth. Eur J Med Chem: 2018, 156;760-773 PubMed 30053719
| Movie of an immobilized zebrafish embryo development from the 1-cell stage to 85 hours post fertilisation (hpf).
- Transition from Prim 5 to Long-pec
- The body axis begins to straighten and the head straightens out and lifts dorsally
- Notochord is well developed
- Formation of the Dorsal and Ventral Stripe
- Nervous system is hollow and expanding anteriorly
- The brain has developed into 5 distinct lobes
- Seven pharyngeal arch's develop rapidly during this stage
- Pectoral fins begin to develop
- The Circulatory system develops and the heart beats for the first time
- Blood begins to circulate through a closed circuit of channels
- Tactile sensitivity appears and uncoordinated movements occur
| Zebrafish Skull Neural Crest Contribution 
Lateral line is a zebrafish sensory system, used to detect changes in water flow, composed of clusters of mechanosensory hair cells called neuromasts.
Fibroblast Growth Factor
- Fgf8 and Fgf3 - regulating the segmentation of the pharyngeal endoderm into pouches.
- Fgf24 and Fgf8 - promotes posterior mesodermal development.
- Sox9 - required for cartilage morphogenesis.
- Kimmel CB, Sessions SK & Kimmel RJ. (1981). Morphogenesis and synaptogenesis of the zebrafish Mauthner neuron. J. Comp. Neurol. , 198, 101-20. PMID: 7229136 DOI.
- Kimmel CB, Sepich DS & Trevarrow B. (1988). Development of segmentation in zebrafish. Development , 104 Suppl, 197-207. PMID: 3077108
- Muto A, Calof AL, Lander AD & Schilling TF. (2011). Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. , 9, e1001181. PMID: 22039349 DOI.
- Naylor RW, Qubisi SS & Davidson AJ. (2017). Zebrafish Pronephros Development. Results Probl Cell Differ , 60, 27-53. PMID: 28409341 DOI.
- Antinucci P & Hindges R. (2016). A crystal-clear zebrafish for in vivo imaging. Sci Rep , 6, 29490. PMID: 27381182 DOI.
- Xu PF, Houssin N, Ferri-Lagneau KF, Thisse B & Thisse C. (2014). Construction of a vertebrate embryo from two opposing morphogen gradients. Science , 344, 87-9. PMID: 24700857 DOI.
- Eames BF, DeLaurier A, Ullmann B, Huycke TR, Nichols JT, Dowd J, McFadden M, Sasaki MM & Kimmel CB. (2013). FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Dev. Biol. , 13, 23. PMID: 23714426 DOI.
- Vesterlund L, Jiao H, Unneberg P, Hovatta O & Kere J. (2011). The zebrafish transcriptome during early development. BMC Dev. Biol. , 11, 30. PMID: 21609443 DOI.
- Carney TJ, Feitosa NM, Sonntag C, Slanchev K, Kluger J, Kiyozumi D, Gebauer JM, Coffin Talbot J, Kimmel CB, Sekiguchi K, Wagener R, Schwarz H, Ingham PW & Hammerschmidt M. (2010). Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. PLoS Genet. , 6, e1000907. PMID: 20419147 DOI.
- Swinburne IA, Mosaliganti KR, Green AA & Megason SG. (2015). Improved Long-Term Imaging of Embryos with Genetically Encoded α-Bungarotoxin. PLoS ONE , 10, e0134005. PMID: 26244658 DOI.
- Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T & Fisher S. (2012). Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS ONE , 7, e47394. PMID: 23155370 DOI.
- Crump JG, Maves L, Lawson ND, Weinstein BM & Kimmel CB. (2004). An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development , 131, 5703-16. PMID: 15509770 DOI.
- Draper BW, Stock DW & Kimmel CB. (2003). Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Development , 130, 4639-54. PMID: 12925590 DOI.
- Yan YL, Miller CT, Nissen RM, Singer A, Liu D, Kirn A, Draper B, Willoughby J, Morcos PA, Amsterdam A, Chung BC, Westerfield M, Haffter P, Hopkins N, Kimmel C, Postlethwait JH & Nissen R. (2002). A zebrafish sox9 gene required for cartilage morphogenesis. Development , 129, 5065-79. PMID: 12397114
Zebrafish "is the only peer-reviewed journal to focus on the zebrafish, which has numerous valuable features as a model organism for the study of vertebrate development. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is a prime model for genetic and developmental studies, as well as research in toxicology and genomics. While genetically more distant from humans, the vertebrate zebrafish nevertheless has comparable organs and tissues, such as heart, kidney, pancreas, bones, and cartilage." [jour PubMed listing]
Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, Metz JR, van der Sar AM, Schaaf MJ, Schulte-Merker S, Spaink HP, Tak PP, Verbeek FJ, Vervoordeldonk MJ, Vonk FJ, Witte F, Yuan H & Richardson MK. (2009). Zebrafish development and regeneration: new tools for biomedical research. Int. J. Dev. Biol. , 53, 835-50. PMID: 19557689 DOI.
Bakkers J, Verhoeven MC & Abdelilah-Seyfried S. (2009). Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Dev. Biol. , 330, 213-20. PMID: 19371733 DOI.
Chan TM, Longabaugh W, Bolouri H, Chen HL, Tseng WF, Chao CH, Jang TH, Lin YI, Hung SC, Wang HD & Yuh CH. (2009). Developmental gene regulatory networks in the zebrafish embryo. Biochim. Biophys. Acta , 1789, 279-98. PMID: 18992377 DOI.
Search Pubmed: Zebrafish Development
- deep cell layer - (DEL) formed after blastula stage that forms the three germ layers (ectoderm, mesoderm, and endoderm).
- epiboly - (Greek, "epibol" = a throwing or laying on) Term describing the division and movement of ectodermal cells during gastrulation, thinning and spreading this layer to cover the whole of the embryo. Cellular movements are thought to occur in all vertebrates, but have been most clearly identified in both the zebrafish and frog (xenopus laevis).
- enveloping layer - (EVL) an epithelial monolayer formed after blastula stage that undergoes epiboly.
- Kupffer's vesicle - (ciliated organ of asymmetry, primitive node) a transient epithelial fluid-filled sac located midventrally posterior to the yolk cell or its extension. The vesicle has been described as equivalent to the primitive node for establishing embryo left-right (L-R) axis. PMID 21876750 PMID 30016568
- yolk syncytial layer - (YSL) membrane-enclosed group of nuclei that lie on top of the yolk cell formed after blastula stage that undergoes epiboly.
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- NIH NIH Zebrafish Initiative
- ZFIN - The Zebrafish Model Organism Database
- Keller at European Molecular Biology Laboratory, Germany Movies - Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
- YouTube Timelapse recording of about 18 hours of embryonic development of the zebrafish with some annotation
- Fish Face Atlas 3D-interactive atlas of craniofacial development in the zebrafish Danio rerio.
- Zebrafish Atlas
- 3D Atlas of Zebrafish Vasculature Anatomy
- Zebrafish Brain Atlas
- Atlas of Zebrafish Anatomy
- Atlas of Zebrafish Development
- Zebrafish Anatomy Portal
- FishNet 3D developmental atlas
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Cite this page: Hill, M.A. (2018, September 25) Embryology Zebrafish Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Zebrafish_Development