Rat Development

Introduction

Rats (taxon- rattus) are readily available as inbred, outbred and mutant strains. They have been generally beaten as a model by their mice brethren, as the molecular tools that became available (stem cells, knockout genes, etc).

Rat embryos do have the advantage of being much larger than mouse embryos and easy to breed. Another advantage of rats is in vision development studies, as that retinal development continues postnatally (most vertebrate neurological systems are difficult to access during periods of development). Rat development is also generally 1 day behind that of mouse. (The table below gives details relating to the staging of rat development). Below this are a list of internet resources relating to the rat. This model organism has only a relatively small amount (0.2 %) of the total rat genome sequenced. (More? see rat genome)

Links: original Rat page

Some Recent Findings

Generation and characterization of a Tet-On (rtTA-M2) transgenic rat. Sheng Y, Lin CC, Yue J, Sukhwani M, Shuttleworth JJ, Chu T, Orwig KE. BMC Dev Biol. 2010 Feb 16;10:17. PMID: 20158911

"This conditional expression rat model may have application for transgenic overexpression or knockdown studies of gene function in development, disease and gene therapy."

References

Search Pubmed: Rat Development

Rat hindbrain E11.5, down-regulated genes and Pax6

Historic Embryology
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Glossary Links

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Cite this page: Hill, M.A. (2024, May 2) Embryology Rat Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Rat_Development

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