Rat Development: Difference between revisions
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:"This conditional expression rat model may have application for transgenic overexpression or knockdown studies of gene function in development, disease and gene therapy." | :"This conditional expression rat model may have application for transgenic overexpression or knockdown studies of gene function in development, disease and gene therapy." | ||
Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. Ahmed RP, Haider KH, Shujia J, Afzal MR, Ashraf M. PLoS One. 2010 Jan 5;5(1):e8576. | |||
[http://www.ncbi.nlm.nih.gov/pubmed/20052412 PMID: 20052412] | |||
:"Reprogramming of stem cells with Shh maximizes their survival and angiogenic potential in the heart via iNOS/netrin-1/PKC signaling." | |||
==References== | ==References== |
Revision as of 07:08, 29 March 2010
Introduction
Rats (taxon- rattus) are readily available as inbred, outbred and mutant strains. They have been generally beaten as a model by their mice brethren, as the molecular tools that became available (stem cells, knockout genes, etc).
Rat embryos do have the advantage of being much larger than mouse embryos and easy to breed. Another advantage of rats is in vision development studies, as that retinal development continues postnatally (most vertebrate neurological systems are difficult to access during periods of development). Rat development is also generally 1 day behind that of mouse. (The table below gives details relating to the staging of rat development). Below this are a list of internet resources relating to the rat. This model organism has only a relatively small amount (0.2 %) of the total rat genome sequenced. (More? see rat genome)
Links: original Rat page
Some Recent Findings
Generation and characterization of a Tet-On (rtTA-M2) transgenic rat. Sheng Y, Lin CC, Yue J, Sukhwani M, Shuttleworth JJ, Chu T, Orwig KE. BMC Dev Biol. 2010 Feb 16;10:17. PMID: 20158911
- "This conditional expression rat model may have application for transgenic overexpression or knockdown studies of gene function in development, disease and gene therapy."
Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. Ahmed RP, Haider KH, Shujia J, Afzal MR, Ashraf M. PLoS One. 2010 Jan 5;5(1):e8576. PMID: 20052412
- "Reprogramming of stem cells with Shh maximizes their survival and angiogenic potential in the heart via iNOS/netrin-1/PKC signaling."
References
Search Pubmed: Rat Development
Animal Development: axolotl | bat | cat | chicken | cow | dog | dolphin | echidna | fly | frog | goat | grasshopper | guinea pig | hamster | horse | kangaroo | koala | lizard | medaka | mouse | opossum | pig | platypus | rabbit | rat | salamander | sea squirt | sea urchin | sheep | worm | zebrafish | life cycles | development timetable | development models | K12 |
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Cite this page: Hill, M.A. (2024, May 19) Embryology Rat Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Rat_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G