Guinea Pig Development: Difference between revisions
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:'''Links:''' [[Abnormal_Development_-_Maternal_Hyperthermia|Maternal Hyperthermia]] | :'''Links:''' [[Abnormal_Development_-_Maternal_Hyperthermia|Maternal Hyperthermia]] | [[Paper - Studies on guinea pig oocytes 1|1964 Oocyte EM]] | ||
==Some Recent Findings== | ==Some Recent Findings== | ||
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* '''Morphometric analysis of fetal development of Cavia porcellus (Linnaeus, 1758) by ultrasonography-Pilot study''' | * '''Morphometric analysis of fetal development of Cavia porcellus (Linnaeus, 1758) by ultrasonography-Pilot study'''{{#pmid:24560548|PMID24560548}} "Measurements on the growth process and placental development of the embryo and fetuses of Cavia porcellus were carried out using ultrasonography. Embryo, fetus, and placenta were monitored from Day 15 after mating day to the end of gestation. Based on linear and quadratic regressions, the following morphometric analysis showed a good indicator of the gestational age: placental diameter, biparietal diameter, renal length, and crown rump. The embryonic cardiac beat was first detected at an average of 22.5 days. The placental diameter showed constant increase from beginning of gestation then remained to term and presented a quadratic correlation with gestational age (r(2) = 0.89). Mean placental diameter at the end of pregnancy was 3.5 ± 0.23 cm. By Day 30, it was possible to measure biparietal diameter, which followed a linear pattern of increase up to the end of gestation (r(2) = 0.95). Mean biparietal diameter in the end of pregnancy was 1.94 ± 0.03 cm. Kidneys were firstly observed on Day 35 as hyperechoic structures without the distinction of medullar and cortical layers, thus the regression model equation between kidney length and gestational age presents a quadratic relationship (r(2) = 0.7). The crown rump presented a simple linear growth, starting from 15 days of gestation, displaying a high correlation with the gestational age (r(2) = 0.9). The offspring were born after an average gestation of 61.3 days. In this study, we conclude that biparietal diameter, placental diameter, and crown rump are adequate predictive parameters of gestational age in guinea pigs because they present high correlation index." | ||
* '''Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains''' | |||
* '''Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains'''{{#pmid:22383778|PMID22383778}} "Chronic intrauterine hypoxia (HPX) decreased pro- and active caspase 3, caspase 3 activity, and DNA fragmentation levels in fetal hearts compared with normoxic controls. L-N6-(1-iminoethyl)-lysine prevented the HPX-induced decrease in caspase 3 activity but did not alter DNA fragmentation levels. In contrast, chronic HPX increased both apoptotic indices in fetal brains, which were inhibited by LNIL. Thus, the effect of HPX on apoptosis differs between fetal organs, and nitric oxide (NO) may play an important role in modulating these effects." | |||
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===Reviews=== | ===Reviews=== | ||
===Articles=== | ===Articles=== | ||
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[[Category:Guinea Pig]] | [[Category:Guinea Pig]] |
Revision as of 22:06, 23 April 2018
Embryology - 26 Apr 2024 Expand to Translate |
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Introduction
Embryos from the guinea pig (Cavia porcellus) have been used in various tetragenic studies, including the effects of elevated body temperature on embryonic development. Postnatally guinea pigs can become sexually mature as early as four weeks.
Historically, it was the Spanish conquistadors who approximately 400 years ago brought guinea pigs to Europe from South America, where they are native.
Nutritional research using guinea pigs showed that scurvy was due to a lack dietary vitamin C, and they have also been used for other dietary requirement studies.
The guinea pig middle ear ossicles, malleus and incus, are a single fused complex, compared to humans where they are two separate bones.
- Links: Maternal Hyperthermia | 1964 Oocyte EM
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Guinea Pig Embryology <pubmed limit=5>Guinea Pig Embryology</pubmed> |
Taxon
Cavia porcellus
Taxonomy Id: 10141 Preferred common name: domestic guinea pig Rank: species
Genetic code: Translation table 1 (Standard) Mitochondrial genetic code: Translation table 2 Other names: Cavia cobaya[synonym], Cavia aperea porcellus[synonym], guinea pig[common name]
Lineage( abbreviated ): Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Hystricognathi; Caviidae; Cavia
Development Overview
Lifespan: (maximum) 12 years, (average) 5 years.
Sexual maturity: 4-6 weeks
Estrous cycle: 15-17 days
Gestation period: 67-69 days
Average litter size: 3 pups (range 1 - 4)
Weaning age: 3 weeks
Estrous Cycle
- Links: Estrous Cycle
Hyperthermia and Development
Guinea pigs have been successfully used as a sensitive model system for the effects of maternal hyperthermia (high body temperature/fever) upon development. This is an excellent example of a maternal environmental effect on embryonic development and neurological effects have also been demonstrated in other rodent model systems. (More? Abnormal Development- Maternal Effects | Hyperthermia and Development)
Cawdell-Smith J, Upfold J, Edwards M, Smith M. Neural tube and other developmental anomalies in the guinea pig following maternal hyperthermia during early neural tube development. Teratog Carcinog Mutagen. 1992;12(1):1-9. "Guinea pigs were exposed to hyperthermia for 1 hr once or twice on day 11, 12, 13, or 14 (E11-E14) of pregnancy. The mean rectal temperatures were elevated by 3.4 degrees C-4.0 degrees C. This treatment resulted in a marked elevation of rates of resorption and developmental defects in embryos examined at day E23. The defects observed were those affecting the neural tube (NTD) (exencephaly, encephaloceles, and microphthalmia), kyphosis/scoliosis, branchial arch defects, and pericardial edema. Embryos with NTD and kyphosis/scoliosis have not been found among newborn guinea pigs to date following maternal heat exposure on days E12-E14. It appears that embryos with these defects are filtered out by resorption or abortion by days E30-E35." (More? see Marsh Edwards | Upfold etal., 1989)
Guinea Pig Research Characteristics
The following lists reasons why the guinea pig is an excellent model animal system for development studies.
- Long Gestation Period With Mature Central Nervous System at Birth - toxicology and teratology studies.
- Sensitivity of Respiratory System - asthma and environmental pollution studies.
- Anatomy of the Guinea Pig Ear - inner ear studies because it is easily dissected and exposed.
- Vitamin C Requirement - wound healing. bone, tooth and atherosclerosis studies.
- Guinea Pig serum - Possesses hemolytic complement with higher activity levels than other lab animals. Widely used as a source of complement for complement fixation test.
- Susceptibility to Infectious Diseases - sentinel animals because of their acute susceptibility to Coxiella burnetii., Mycobacterium sp. and Listeriosis.
- Similar lmmune System to Man - immune system possesses a similar antigen-macrophage interaction to man and delayed cutaneous hypersensitivity reaction.
- High Dietary Requirements - folic acid, thiamine, arginine and potassium make guinea pigs useful in nutrition studies.
- Precocious Young - good for germ free raising.
- Quiet Calm Disposition - entomology studies, used to test repellents and insecticides, and as feeding source for biting insects.
- Text modified from Washington University - NetVet Guinea Pig Models and Uses in Research Notes
References
- ↑ Santos J, Fonseca E, van Melis J & Miglino MA. (2014). Morphometric analysis of fetal development of Cavia porcellus (Linnaeus, 1758) by ultrasonography--pilot study. Theriogenology , 81, 896-900. PMID: 24560548 DOI.
- ↑ Evans LC, Liu H & Thompson LP. (2012). Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains. Reprod Sci , 19, 298-305. PMID: 22383778 DOI.
Search Pubmed: Guinea Pig Development
Reviews
Articles
Bellinger SA, Lucas D & Kleven GA. (2015). An ecologically relevant guinea pig model of fetal behavior. Behav. Brain Res. , 283, 175-83. PMID: 25655512 DOI.
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Washington University NetVet - General Notes on Guinea Pigs | Guinea Pig - Models and Uses in Research (Notes) | Biology and Care of Guinea Pigs (Notes) | Diseases of Guinea Pigs (Notes)
- LABORATORY RODENT AND RABBIT EMBRYOS/OVA - Conditions applicable to the maintenance of laboratory animal colonies
- Seagull's Guinea Pig Compendium
- Diseases of Guinea Pigs (AFIP-POLA)
- Elm Hill Breeding Labs
- M & B Breeding and Research Centre Ltd.
- Covance (HRP, Inc.)
- Cavy Spirit
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Cite this page: Hill, M.A. (2024, April 26) Embryology Guinea Pig Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Guinea_Pig_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G