Europe Statistics

Embryology - 11 Dec 2023        Expand to Translate
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Introduction

Europe

See also Germany, Spain and United Kingdom that currently also have separate statistical information pages on this site.

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  Germany

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  Spain

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  United Kingdom

Some Recent Findings

Paper 2: EUROCAT public health indicators for congenital anomalies in Europe. "The purpose of this article is to present the specific public health indicators recently developed by EUROCAT that aim to summarize important aspects of the public health impact of congenital anomalies in a few quantitative measures. The six indicators are: (1) congenital anomaly perinatal mortality, (2) congenital anomaly prenatal diagnosis prevalence, (3) congenital anomaly termination of pregnancy, (4) Down syndrome livebirth prevalence, (5) congenital anomaly pediatric surgery, and (6) neural tube defects (NTD) total prevalence. Data presented for this report pertained to all cases (livebirths, fetal deaths, or stillbirths after 20 weeks of gestation and terminations of pregnancy for fetal anomaly [TOPFA]) of congenital anomaly from 27 full member registries of EUROCAT that could provide data for at least 3 years during the period 2004 to 2008. Prevalence of anomalies, prenatal diagnosis, TOPFA, pediatric surgery, and perinatal mortality were calculated per 1000 births." The prevalence of congenital anomalies in Europe.EUROCAT (European Surveillance of Congenital Anomalies) is the network of population-based registers of congenital anomaly in Europe, with a common protocol and data quality review, covering 1.5 million annual births in 22 countries. EUROCAT recorded a total prevalence of major congenital anomalies of 23.9 per 1,000 births for 2003-2007. 80% were livebirths. 2.5% of livebirths with congenital anomaly died in the first week of life. 2.0% were stillbirths or fetal deaths from 20 weeks gestation. 17.6% of all cases were terminations of pregnancy following prenatal diagnosis (TOPFA). Thus, congenital anomalies overwhelmingly concern children surviving the early neonatal period, who have important medical, social or educational needs. The prevalence of chromosomal anomalies was 3.6 per 1,000 births, contributing 28% of stillbirths/fetal deaths from 20 weeks gestation with congenital anomaly, and 48% of all TOPFA. Congenital heart defects (CHD) were the most common non-chromosomal subgroup, at 6.5 per 1,000 births, followed by limb defects (3.8 per 1,000), anomalies of urinary system (3.1 per 1,000) and nervous system defects (2.3 per 1,000). In 2004, perinatal mortality associated with congenital anomaly was 0.93 per 1,000 births, and TOPFA 4.4 per 1,000 births, with considerable country variation. Primary prevention of congenital anomalies in the population based on controlling environmental risk factors is a crucial policy priority, including preconceptional care and whole population approaches."

Congenital Statistical Data

The following data is from a 2010 EUROCAT paper.

• total prevalence of major congenital anomalies of 23.9 per 1,000 births for 2003-2007.
  • 80% were livebirths.
  • 2.5% of livebirths with congenital anomaly died in the first week of life.
  • 2.0% were stillbirths or fetal deaths from 20 weeks gestation.
• 17.6% of all cases were terminations of pregnancy following prenatal diagnosis (TOPFA).
• prevalence of chromosomal anomalies was 3.6 per 1,000 births.
  • contributing 28% of stillbirths/fetal deaths from 20 weeks gestation with congenital anomaly
  • 48% of all TOPFA.
• Congenital heart defects (CHD) were the most common non-chromosomal subgroup (6.5 per 1,000 births).
• Limb defects (3.8 per 1,000)
• Renal anomalies (3.1 per 1,000)
• Neural defects (2.3 per 1,000).

2004 - perinatal mortality associated with congenital anomaly was 0.93 per 1,000 births, and TOPFA 4.4 per 1,000 births, with considerable country variation.

Malformation (non-chromosomal)	Total Cases	Cases Prenatally Diagnosed	% of Total Cases
All Anomalies	75751	22573	30
Anencephalus and similar	1232	1185	96
Spina Bifida	1577	1288	82
Hydrocephalus	1914	1403	73
Transposition of great vessels	1188	454	38
Hypoplastic left heart	888	624	70
Cleft lip with or without palate	2857	1379	48
Diaphragmatic hernia	893	509	57
Gastroschisis	993	904	91
Omphalocele	730	596	82
Bilateral renal agenesis including Potter syndrome	392	343	88
Posterior urethral valve and/or prune belly	291	234	80
Limb reduction	1626	811	50
Club foot - talipes equinovarus	3678	1398	38

Malformation (non-chromosomal)	Total Cases	Cases Prenatally Diagnosed	% of Total Cases
Chromosomal	12479	8765	70
Down Syndrome	7233	4538	63
Patau syndrome/trisomy 13	685	625	91
Edwards syndrome/trisomy 18	1709	1537	90

Data: EUROCAT Website Database http://www.eurocat-network.eu/PRENATALSCREENINGAndDIAGNOSIS/PrenatalDetectionRates data uploaded 04/12/2012

Denmark

Danish National Birth Cohort

The Danish National Birth Cohort (DNBC) is a large population study related to DOHAD theory, of the exposure during development influence fetal growth, cell divisions, and organ functioning, may have long-lasting impact on health and disease susceptibility. More than 900 PubMed publications refer to the study data.

The Danish National Birth Cohort - its background, structure and aim

"It is well known that the time from conception to early childhood has importance for health conditions that reach into later stages of life. Recent research supports this view, and diseases such as cardiovascular morbidity, cancer, mental illnesses, asthma, and allergy may all have component causes that act early in life. Exposures in this period, which influence fetal growth, cell divisions, and organ functioning, may have long-lasting impact on health and disease susceptibility.

"To investigate these issues the Danish National Birth Cohort (Better health for mother and child) was established. A large cohort of pregnant women with long-term follow-up of the offspring was the obvious choice because many of the exposures of interest cannot be reconstructed with sufficient validity back in time. The study needs to be large, and it is aimed to recruit 100,000 women early in pregnancy, and to continue follow-up for decades. The Nordic countries are better suited for this kind of research than most other countries because of their population-based registers on diseases, demography and social conditions, linkable at the individual level by means of the unique ID-number given to all citizens. Exposure information is mainly collected by computer-assisted telephone interviews with the women twice during pregnancy and when their children are six and 18 months old. Participants are also asked to fill in a self-administered food frequency questionnaire in mid-pregnancy. Furthermore, a biological bank has been set up with blood taken from the mother twice during pregnancy and blood from the umbilical cord taken shortly after birth. Data collection started in 1996 and the project covered all regions in Denmark in 1999. By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this."

Links: DNBC

Germany

Population: 81,471,834 (July 2011 est.) country comparison to the world: 16

Infant mortality rate

• total: 3.54 deaths/1,000 live births
• country comparison to the world: 208
• male: 3.84 deaths/1,000 live births
• female: 3.21 deaths/1,000 live births (2011 est.)

Links:Germany

Italy

Brindisi, Italy

Congenital anomalies among live births in a polluted area"Congenital anomalies and their primary prevention are a crucial public health issue. This work aimed to estimate the prevalence of congenital anomalies in Brindisi, a city in southeastern Italy at high risk of environmental crisis. This research concerned newborns up to 28 days of age, born between 2001 and 2010 to mothers resident in Brindisi and discharged with a diagnosis of congenital anomaly. ...Our findings indicated an increased prevalence of Congenital Anomalies (especially congenital heart diseases) in the city of Brindisi. More research is needed in order to analyze the role of factors potentially involved in the causation of congenital anomalies."

United Kingdom

Population: 62,698,362 (July 2011 est.) country comparison to the world: 22

Infant mortality rate

• total: 4.62 deaths/1,000 live births country comparison to the world: 189
• male: 5.07 deaths/1,000 live births
• female: 4.15 deaths/1,000 live births (2011 est.)

Links: United Kingdom

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

• EUROCAT (European Surveillance of Congenital Anomalies) funding from the European Union, in the framework of the Public Health Programme, a WHO Collaborating Centre for the Surveillance of Congenital Anomalies and based at the University of Ulster. EUROCAT | Prenatal Detection Rates
• European Neonatal Network EuroNeoNet
• European Union http://europa.eu
• Council of Europe http://hub.coe.int Pharmaceutical and Healthcare Europe

Glossary Links

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Cite this page: Hill, M.A. (2023, December 11) Embryology Europe Statistics. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Europe_Statistics

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© Dr Mark Hill 2023, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G