Developmental Signals - Six

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Introduction

Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.


Draft Page.


Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | Nanog | NGF | Nodal | Notch | FOX | Hippo | PAX | retinoic acid | SIX | Slit2/Robo1 | Sox | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

  • Activation of Six1 Expression in Vertebrate Sensory Neurons[1] "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."
More recent papers
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Search term: Development Six

Andrew Rowland, Warit Ruanglertboon, Madelé van Dyk, Dhilushi Wijayakumara, Linda S Wood, Robyn Meech, Peter I Mackenzie, A David Rodrigues, Jean-Claude Marshall, Michael J Sorich Plasma extracellular nanovesicle (exosome) derived biomarkers for drug metabolism pathways: A novel approach to characterise variability in drug exposure. Br J Clin Pharmacol: 2018; PubMed 30340248

Ying Luo, Yihe Lü, Bojie Fu, Qiuju Zhang, Ting Li, Weiyin Hu, Alexis Comber Half century change of interactions among ecosystem services driven by ecological restoration: Quantification and policy implications at a watershed scale in the Chinese Loess Plateau. Sci. Total Environ.: 2018, 651(Pt 2);2546-2557 PubMed 30340190

Robert Colebunders, Gasim Abd-Elfarag, Jane Y Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora Clinical characteristics of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan. Seizure: 2018, 62;108-115 PubMed 30340162

Liselotte W Maassen, Daniëlle M van Gastel, Ilse Haveman, Marlies Y Bongers, Sebastiaan Veersema ##Title## J Minim Invasive Gynecol: 2018; PubMed 30340052

Yan-Ping Liu, Qing-Long Liu, Xiang-Lin Zhang, Hai-Yuan Niu, Chun-Yan Guan, Fu-Kang Sun, Wei Xu, Yan-Hui Fu Bioactive monoterpene indole alkaloids from Nauclea officinalis. Bioorg. Chem.: 2018, 83;1-5 PubMed 30339860

Transcription Factor

Neural Development

Vision Development

Abnormalities

References

  1. Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

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Reviews

Articles

Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

Yajima H, Suzuki M, Ochi H, Ikeda K, Sato S, Yamamura K, Ogino H, Ueno N & Kawakami K. (2014). Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates. BMC Biol. , 12, 40. PMID: 24885223 DOI.

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Cite this page: Hill, M.A. (2018, October 20) Embryology Developmental Signals - Six. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Six

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© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G