Developmental Signals - Six

From Embryology
Embryology - 20 Oct 2018    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)


Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.

Draft Page.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | Nanog | NGF | Nodal | Notch | FOX | Hippo | PAX | retinoic acid | SIX | Slit2/Robo1 | Sox | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

  • Activation of Six1 Expression in Vertebrate Sensory Neurons[1] "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."
More recent papers
Mark Hill.jpg
PubMed logo.gif

This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches

Search term: Development Six

Andrew Rowland, Warit Ruanglertboon, Madelé van Dyk, Dhilushi Wijayakumara, Linda S Wood, Robyn Meech, Peter I Mackenzie, A David Rodrigues, Jean-Claude Marshall, Michael J Sorich Plasma extracellular nanovesicle (exosome) derived biomarkers for drug metabolism pathways: A novel approach to characterise variability in drug exposure. Br J Clin Pharmacol: 2018; PubMed 30340248

Ying Luo, Yihe Lü, Bojie Fu, Qiuju Zhang, Ting Li, Weiyin Hu, Alexis Comber Half century change of interactions among ecosystem services driven by ecological restoration: Quantification and policy implications at a watershed scale in the Chinese Loess Plateau. Sci. Total Environ.: 2018, 651(Pt 2);2546-2557 PubMed 30340190

Robert Colebunders, Gasim Abd-Elfarag, Jane Y Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora Clinical characteristics of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan. Seizure: 2018, 62;108-115 PubMed 30340162

Liselotte W Maassen, Daniëlle M van Gastel, Ilse Haveman, Marlies Y Bongers, Sebastiaan Veersema ##Title## J Minim Invasive Gynecol: 2018; PubMed 30340052

Yan-Ping Liu, Qing-Long Liu, Xiang-Lin Zhang, Hai-Yuan Niu, Chun-Yan Guan, Fu-Kang Sun, Wei Xu, Yan-Hui Fu Bioactive monoterpene indole alkaloids from Nauclea officinalis. Bioorg. Chem.: 2018, 83;1-5 PubMed 30339860

Transcription Factor

Neural Development

Vision Development



  1. Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

Search Bookshelf Six



Sato S, Yajima H, Furuta Y, Ikeda K & Kawakami K. (2015). Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE , 10, e0136666. PMID: 26313368 DOI.

Yajima H, Suzuki M, Ochi H, Ikeda K, Sato S, Yamamura K, Ogino H, Ueno N & Kawakami K. (2014). Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates. BMC Biol. , 12, 40. PMID: 24885223 DOI.

Search Pubmed

Search Pubmed Now: Six

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2018, October 20) Embryology Developmental Signals - Six. Retrieved from

What Links Here?
© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G