Developmental Signals - Fibroblast Growth Factor: Difference between revisions
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:'''Links:''' [[Endoderm]] | [[Chicken Development]] | :'''Links:''' [[Endoderm]] | [[Chicken Development]] | ||
==Mesoderm== | |||
[[File:Model for Sprouty4 and FGF in mesoderm segmentation.jpg|400px]] | |||
A Putative Model for the role of Sprouty4 as a mediator that links the mouse segmentation clock to the gradient of FGF signaling. | |||
<ref name="PMID19440349"><pubmed>19440349</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680047 PMC2680047] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005603 PLoS One]</ref> | |||
The FGF signaling may be periodically inhibited by Sprouty4, by which temporal periodicity of Notch segmentation clock may be translated to spatial periodicity of the array of somites. | |||
* In the PSM - FGF signaling establishes a posterior-to-anterior gradient, which is involved in the positioning of presumptive somite boundaries. | |||
* Cyclic Sprouty4 | |||
** which is controlled by the Notch segmentation clock, the mechanism of which includes negative feedback loop of Hes7, | |||
** may inhibit the FGF signaling possibly around the anterior border of the FGF signaling positive area | |||
** where the FGF signaling is close to its threshold. | |||
* '''S''' - somite | |||
* '''PS''' - presumptive somite. | |||
:'''Links:''' [[Somitogenesis]] | [[Musculoskeletal System - Axial Skeleton Development|Axial Skeleton Development]] | [[Developmental Signals - Notch|Notch]] | [[Developmental_Signals_-_Fibroblast_Growth_Factor|FGF]] | |||
==Abnormalities== | ==Abnormalities== |
Revision as of 12:30, 17 August 2015
Embryology - 14 May 2024 Expand to Translate |
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Introduction
Fibroblast Growth Factors (FGF) were originally identified by their ability to stimulate fibroblast cell proliferation but have a role in a growing number of different tissues development and differentiation and continue to have a role in the adult.
The first two identified factors were originally given the nomenclature of acidic or basic. We now know there to be at least 22 different human FGFs (Fgf1–Fgf23). These protein growth factors are bound by 4 different cell membrane receptors (FGFR1-4). FGFRs belong to the tyrosine kinase receptor family.
The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the endocrine hormone-like Fgf15/21/23 subfamily (hFGFs), and the paracrine canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Protein Properties
Human FGF
- ~150–300 amino acids
- have a conserved ~120-residue core with ~30–60% identity
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Fibroblast Growth Factor <pubmed limit=5>Fibroblast Growth Factor</pubmed> |
Endoderm
Chicken antero-posterior endoderm patterning[6]
- Links: Endoderm | Chicken Development
Mesoderm
A Putative Model for the role of Sprouty4 as a mediator that links the mouse segmentation clock to the gradient of FGF signaling. [7]
The FGF signaling may be periodically inhibited by Sprouty4, by which temporal periodicity of Notch segmentation clock may be translated to spatial periodicity of the array of somites.
- In the PSM - FGF signaling establishes a posterior-to-anterior gradient, which is involved in the positioning of presumptive somite boundaries.
- Cyclic Sprouty4
- which is controlled by the Notch segmentation clock, the mechanism of which includes negative feedback loop of Hes7,
- may inhibit the FGF signaling possibly around the anterior border of the FGF signaling positive area
- where the FGF signaling is close to its threshold.
- S - somite
- PS - presumptive somite.
- Links: Somitogenesis | Axial Skeleton Development | Notch | FGF
Abnormalities
- FGFR1 mutation has been associated with the relatively milder form of Pfeiffer syndrome type 1.
- FGFR2 and FGFR3 have been associated with the Apert, Crouzon and Pfeiffer syndromes.
References
- ↑ Itoh N. Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Cell Tissue Res. 2010 Oct;342(1):1-11. PMID20730630
- ↑ 2.0 2.1 <pubmed>24304493</pubmed>| BMC Dev Biol.
- ↑ <pubmed>22988910</pubmed>
- ↑ <pubmed>21074523</pubmed>
- ↑ <pubmed>19741606</pubmed>
- ↑ 19516907</pubmed>| PLoS One.
- ↑ <pubmed>19440349</pubmed>| PMC2680047 | PLoS One
Reviews
Articles
<pubmed>20582225</pubmed>
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