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:(cardiomyocyte) The mature cardiac (heart) muscle cell. Cardiac muscle cells are striated, joined by specialised junctions (intercalated discs) and innervated by the autonomic nervous system. | :(cardiomyocyte) The mature cardiac (heart) muscle cell. Cardiac muscle cells are striated, joined by specialised junctions (intercalated discs) and innervated by the autonomic nervous system. | ||
:(More? [[2009 Lecture 22| | :(More? [[Cardiovascular System Development]] | [[2009 Lecture 22|Lecture - Heart Development]]) | ||
===Carnegie stages=== | ===Carnegie stages=== |
Revision as of 16:03, 9 November 2010
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link | Original C
c-section
- abbreviation of "caesarian section" also can be further shortened as acronym C/S (see caesarian section).
caesarian
- The surgical delivery of fetus through abdominal incision. Named after the roman emperor Caesar who was delivered by this method. Please note the UK/Australian "Caesarean" versus USA "Cesarean" spelling differences.
- (More? Birth - Caesarean Delivery)
cafe-au-lait spots
- (French, cafe-au-lait = coffee with milk) term used to describe the appearance of a type of skin blemishes that can be associated with a neural crest disorder, Neurofibromatosis Type 1.
Cajal bodies
- (CB) Ramon y Cajal originally identified these small nuclear organelles in cells, they have various suggested functions and are localized to the nucleolar periphery or within the nucleoli.
calcium channel blocker
- (nifedipine) A clinical tocolytic agent used to inhibit labor (labor-inhibiting), slowing or halting uterine contractions. These drugs are used clinically to treat premature labor and permit continued fetal growth before parturition. Act on uterine smooth muscle cells to directly block the influx of calcium ions through the cell membrane, inhibit the release of sarcoplasmic reticulum (SR) intracellular calcium and increase calcium efflux from the cell.
- (More? Birth)
Call-Exner bodies
- A histological feature seen in the developing ovarian follicle granulosa layer of some species, including human. Appears as a spherical space staining as an eosinophilic region and contains basal lamina components (type IV collagen and laminin) similar to thiose of the follicular basal lamina.
- (More? Oocyte Development | Week 1)
calmodulin-dependent protein kinase II
- (CamKII, CaM kinase II) A signaling protein serine/threonine protein kinase in pathways that use calcium ions Ca(2+) as a second messenger. A recent mouse study has shown that the CamKII isoform, gamma 3 isoform is involved in signaling for oocytes arrested at meiotic metaphase II to resume meiosis (not cortical granule release) following fertilization.
calprotectin
- (leukocyte L1) A calcium and zinc binding protein (36 kDa) that forms about 60% of soluble cytosol protein in human neutrophil granulocytes, and is also found in monocytes, macrophages and epithelial cells. During the neonatal period, the high fecal calprotectin (f-calprotectin) values observed in preterm infants may be linked to the establishment of gut bacteria.
- (More? PLoS)
calvaria
- The term used to describe the skull formed from frontal, parietal and occipital bones.
- (More? Head Development | Lecture - Musculoskeletal Development | Musculoskeletal System - Skull Development)
camptodactyly
- A term describing abnormal development resulting in a permanent flexion contracture of a finger or toe.
canalicular stage
- (fetal canalicular, canalicular phase) Term used to describe lung development, after early embryonic the second of the histological/developmental stages (pseudoglandular, fetal canalicular, terminal sac, alveolar). This stage occurs during the fetal period from week 16 to 24. During this stage there is lung bud mesenchymal angiogenesis and cellular differentiation into different stromal cell types (fibroblasts, myoblasts and chondrocytes).
- Lung stages: respiratory embryonic stage - pseudoglandular stage - canalicular stage - terminal sac stage - alveolar stage
cancelled cycle
- (canceled cycle) An in vitro fertilization (ART) cycle in which ovarian stimulation was carried out but which was stopped before eggs were retrieved, or in the case of frozen embryo cycles, before embryos were transferred.
- (More? In Vitro Fertilization)
Cantrell's pentalogy
- (pentalogy of Cantrell) A rare human developmental syndrome involving 5 key abnormalities: midline abdominal wall defect, lower sternum defect, anterior diaphragm defect, diaphragmatic pericardium defect and congenital heart malformation.
- (More? OMIM 313850)
capacitation
- The process by which sperm become capable of fertilizing an egg, requires membrane changes, removal of surface glycoproteins and increased motility.
cardiac jelly
- Term used in early heart development to describe the initial gelatinous or sponge-like connective tissue separating the myocardium and the heart tube endothelium.
cardinal vein
- The name given to the initial embryonic vessels that will form the systemic venous system. This vascular system, like most early vessels, develop initially bilaterally and symmetrical.
cardiocyte
- (cardiomyocyte) The mature cardiac (heart) muscle cell. Cardiac muscle cells are striated, joined by specialised junctions (intercalated discs) and innervated by the autonomic nervous system.
Carnegie stages
- Carnegie stages are a system of classifying embryonic development based on the external features and related internal changes that affect appearance and growth of the embryo. Note that the stages are not directly dependent on either age or size, but upon the appearance of specific embryonic features. Early human and other species embryos can be classified by these stages. The term "carnegie stages" are named after the famous USA Institute which began collecting and classifying embryos in the early 1900's.
- (More? Embryonic Development)
Carney complex
- (CNC) Human genetic disorder, a rare familial disease characterized by a predisposition to develop multiple endocrine tumours including Cushing's syndrome.
carotid stenosis
- The narrowing of the blood vessels in the neck, carotid arteries, that supply blood to the brain.
cartilage
- The connective tissue formed from mesoderm by the process of chondrogenesis. In the embryo cartilage initially forms most of the skeleton and is later replaced by bone (ossification). In the adult, cartilage is found in many skeletal regions including the surface of bone joints.
- (More? 2009 Lecture - Musculoskeletal Development | Musculoskeletal Development - Cartilage Development | Musculoskeletal Development)
catabolism
- (Greek, cata = down + ballein = to throw) The reactions of metabolism that break down complex molecules, such as those in food.
catagen
- The end of active growing phase of the life cycle of the hair, between growing phase (anagen) and resting stage (telogen).
- (More? Hair Development)
catenin
- (β-Catenin) Beta-catenin is a protein that binds E-cadherin in the formation of intercellular adhesions. In development, the protein is also a key component of the Wnt signaling intracellular pathway that controls cell proliferation and differentiation.
- (More? Wnt)
cauda equina
- (Latin, cauda equina = horse's tail) The lower end, caudal, extension of the mature spinal cord. This anatomical feature develops due to the growth, in length, of the vertebral column while the spinal cord does not elongate at the same rate.
caudal
- (Latin, caudal = tail) Anatomical term referring to structures that are more towards the tail.
caudal neuropore
- (posterior neuropore, Latin, caudal = tail) The opening of the early neural tube at the spinal cord end or the tail region. Initially when the neural plate folds and fuses it leaves two openings at either end cranial and caudal that close later. In humans, the caudal neuropore closes from Carnegie stage 12 (about 26 days) over a day. Failure of caudal neuropore to close can lead to the neural tube defect (NTD) spina bifida.
cavitates
- Term used to describe the process of formation of a space within an existing solid object. This process occurs developmentally in a number of different structures: in the early blastocyst forming the blastocoel, within early somites forming the somitocoel.
cavum septi pellucidi
- (CSP, cavum septum pellucidum) Part of the septohippocampal system, a brain space filled with cerebrospinal fluid (CSF) present during fetal development and lost postnatally (85% fuse by 3–6 months of age). The septum pellucidum forms the medial walls of the lateral ventricles as a thin plate of two laminae that fuse, failure to fuse forms this cavity. This space is visible in fetal ultrasound scans and is one of the landmark parameter for the measurement of Head Circumference (HC) when determining fetal age/growth.
- (More? Ultrasound | Figure - Ventricular space cartoon | Head | Fetal Development | Birth | PMID3813041)
CBU
- Acronym for Cord Blood Units, used in defining quantities of placental cord blood collected.
- (More? Stem Cells - Cord Blood)
CCN
- Acronym for Connective tissue growth factor (CTGF), Cystein rich protein (Cyr61), and Nephroblastoma overexpressed gene (nov). A family of both positive and negative regulatory proteins involved in many different cellular processes (survival, cell adhesion, migration, and proliferation). Three genes involved in the Wnt1 signalling pathway (WISP-1, WISP-2, WISP-3) have been shown to be highly related to the CCN family of genes.
- (More? Notochord)
cell division
- The process by which a parent cell gives rise to two daughter cells that carry the same genetic information as the parent cell. All body cells divide by the process called mitosis, except germ cells which undergo meiosis. Meiosis is a DNA reductive cell division (diploid to haploid).
- (More? Cell Division - Mitosis | Cell Division - Meiosis | Week 1)
Cell Theory
- The historic theory that states: (1) All organisms are composed of one or more cells; (2) cells themselves are alive and are the basic living unit of function and organization of all organisms; (3) all cells come from other cells.
- (More? UNSW Cell Biology)
cellular oncogene
- A normal gene (proto-oncogene) which when mutated can cause unregulated cellular growth and proliferation, cancer.
central canal
- The lumen or cavity of neural tube lying within the spinal cord. This space is continuous with ventricular system of the brain.
- (More? Neural Notes)
Central Dogma
- The theory that states "DNA specifies RNA, which specifies proteins."
central nervous system
- (CNS) The part of the nervous system made up of the brain and spinal cord. Both structures form from the neural tube which is ectoderm in origin.
centre of ossification
- (ossification centre) The region where bone formation commences within embryonic connective tissue. In endochondrial ossification, this process occurs within cartilage. In membranous ossification, this process occurs within a membrane.
centriole
- A pair of small cylindrical structures each about 0.2 micron in diameter and 0.4 micron long, that lie at right angles to one another; present at each pole of the mitotic spindle in animal cells and in some other eukaryotes.
centripetal
- (Latin, centripetal = center seeking) Term used to describe the direction of growth, movement or migration.
centromere
- The point at which the two chromatids of a single chromosome are joined.
cephalic
- (Greek, kephale = head) Term used to relate to the head or sometimes towards the upper body.
- (More? Head Development)
cephalic presentation
- (Greek, kephale = head) Alternate clinical (obstetric) term for vertex presentation used in birth, referring to when the fetal head is closest to the cervix, hence "presentation". The most common and safest human birth position.
- (More? Birth)
cerebellum
- (Latin, cerebellum = little brain) A central nervous system component formed from the rhombencephalon (hindbrain) region of the neural tube. The cerebellum is required for coordinated motor activities. Cells within the cerebellum are formed by the ventricular zone of the roof of the fourth ventricle and the second germinal zone (Rhombic lip).
cerebral aqueduct
- A narrow ventricular cavity within the mesencephalon formed from the cavity within the neural tube.
- (More? Neural System Development)
cerumen
- The ear wax which is secreted by apocrine glands in the ear canal (external auditory meatus).
- (More? Hearing and Balance | Outer Ear)
cervical cerclage
- A clinical birth procedure involving circumferential banding or suture of the cervix early (between 12 -14 weeks) or when required to prevent or treat passive dilation prior to completion of pregnancy (37 weeks), described as cervical insufficiency.
- (More? Birth)
cervical flexure
- In development of the central nervous system brain region, the most caudal early neural tube flexure (cranial flexure, pontine flexure and cervical flexure)) lying between spinal cord and rhombencephalon.
- (More? Neural System Development)
cervical insufficiency
- (CI) A clinical term describing a painless and progressive dilatation and effacement of the cervix that may lead to second trimester abortions or preterm delivery. It has also been described as inability of the uterine cervix to retain a pregnancy in the absence of uterine contractions. The condition may in some instances treated clinically by cervical cerclage. The biological basis is currently undetermined with some evidence showing a genetic relationship.
cervical mucus plug
- (CMP) During early pregnancy, glands located at the cervical junction between vagina and uterus secrete mucus that forms a plug or barrier between these two structures.
- (More? Birth)
cervical pregnancy
- A rare type of ectopic pregnancy with implantation at the cervical canal, occurring with an incidence ranging between 1:1,000 and 1:18,000 pregnancies. Clinically, when an associated haemorrhage occurs a hysterectomy is usually performed.
cervical ripening
- Clinical birth term describing the hormonal softening of the cervix to allow expansion in preparation for birth.
- (More? Birth)
cervical sinus
- An ectodermal depression visible externally at the level of the neck during embryonic development (approx carnegie stage 14-16), which marks the region where 2nd pharyngeal arch has grown over 3rd and 4th arches.
cesarean
- The surgical delivery of fetus through abdominal incision. Named after the roman emperor Caesar who was delivered by this method. Please note the UK/Australian "Caesarean" versus USA "Cesarean" spelling differences.
- (More? Birth)
CHARGE Syndrome
- Each letter sands for an associated disorder of the syndrome: Coloboma on the eye , Heart, Atresia of choane , Retardation of growth , Genital malformations, Ear malformations and/or deafness. CHARGE syndrome has an estimated birth incidence of 1 in 12,000 and is a common cause of congenital anomalies. Most affected individuals with CHARGE syndrome have mutations involving the chromodomain helicase DNA-binding protein-7
Chiari malformation
- (Chiari I and II malformation, Arnold-Chiari malformation) Developmental abnormality with a reduced posterior fossa and herniation of the hindbrain (cerebellum, brainstem) through the foramen magnum. The two types differ in severity: Type I can be asymptomatic and Type II (Arnold-Chiari malformation) is more severe and can have other associated abnormalities, such as myelomeningocele.
chemoattractive
- (chemotaxis, attractive guidance cue) A positive chemotaxis guidance or cue, where a substance stimulates the cell migration or growth of part of a cell towards a target. In development, this can also be combined with chemorepellent guidance, inhibiting growth or migration in a particular direction.
chemorepellent
- (repulsive guidance cue) A negative chemotaxis guidance, where a substance inhibits the cell migration or growth of part of a cell towards a target. In neural development, a series of chemoattractive and chemorepellent cues guide axon growth during the formation of neural connections.
- (More? semaphorin 3a)
chemotaxis
- (chemoattractive) The movement of a cell or part of a cell towards a higher (or, in some cases, a lower) concentration of a particular substance (chemical or protein) produced or located at a target region in the embryo.
chiasma
- (Greek, chiasma = cross; plural, chiasmata) The sites of exchange of DNA between homologous chromosomes during meiosis; visible during prophase of meiosis I.
- (More? Cell Division - Meiosis)
chimera
- (Greek, pronounced ky-MIR-uhs) A mythical monster with the head of a lion, the body of a goat, and the tail of a serpent. Today used to describe a mixing of biological molecules either: 1. animals that have been genetically engineered 2. development studies where different species cells have been mixed, example chick-quail chimera, 3. Modified proteins containing parts of 2 different proteins.
- (More? Neural Crest Development)
cholangiocyte
- Bile duct epithelial cell derived from hepatoblasts during embryonic liver development. These cells line the bile duct system and have apical cilia. Cholangiocytes function (mechano-, osmo-, and chemo-sensory) to regulate the fluidity and alkalinity of canalicular bile by reabsorptive and secretory events adjusting the final secreted bile composition. Abnormalities associated with these cells development or function are called cholangiociliopathies (polycystin-1, polycystin-2, and fibrocystin).
cholecystitis
- Inflammation of the gall bladder generally caused by gallstones obstructing the duct from gall bladder to common bile duct and can occur in maternal gall bladder during pregnancy.
- (More? Gastrointestinal Tract Development | Medline Plus Acute cholecystitis (Gallstones) | The Merck Manual Cholecystitis)
chondrodysplasia
- Term used to describe skeletal malformation due to perturbation of chondrocyte differentiation program at the growth plate.
- (More? Cartilage Development | [[Musculoskeletal System Development|Musculoskeletal Development])
chondrogenesis
- the process of forming cartilage, which is a connective tissue formed from mesoderm (or neural crest in the head region). In the embryo, cartilage initially forms most of the skeleton and is later replaced by bone (ossification). In the adult, cartilage is found in many skeletal regions including the surface of bone joints.
- (More? Cartilage Development | [[Musculoskeletal System Development|Musculoskeletal Development])
chordae tendineae
- Within the heart ventricles, a series of tendinous chords connecting the ventricular papillary musclular walls with the atrioventricular valves (bicuspid, tricuspid). The ventricular wall attachment is through the trabeculae (trabeculae carneae).
chorioamnionitis
- (CA) An intraamniotic puerperal infection described as having 3 forms: histologic, clinical (clinical chorioamnionitis, IAI), and subclinical. Intraamniotic infection is a common (2-4%) event in labor and the systemic inflammatory response can also lead to preterm birth and neonatal complications.
- (More? Placenta Development)
chorion
- The extraembryonic membrane generated from trophoblast and extraembryonic mesoderm that forms placenta. chorion and amnion are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange.
- (More? Placenta Development)
chorionic cavity
- The fluid-filled extraembryonic coelom (cavity) formed initially from trophoblast and extraembryonic mesoderm that forms placenta. chorion and amnion are made by the somatopleure. The chorion becomes incorporated into placental development. The avian and reptilian chorion lies beside the egg shell and allows gas exchange. In humans, this cavity is lost during week 8 when the amniotic cavity expands and fuses with the chorion.
- (More? Placenta Development)
chorion frondosum
- (frondosum = leafy) The chorion found on conceptus oriented towards maternal blood supply where the majority of villi form and proliferate, will contribute the fetal component of the future placenta.
- (More? Placenta Notes | Week 2 Notes | Week 3 Notes)
chorion laeve
- (laeve = smooth) The smooth chorion found on conceptus away from maternal blood supply (towards uterine epithelium and cavity) with very few villi present.
- (More? Placenta Development | Week 2 | Week 3)
chorionic gonadotropin
- (CG, human chorionic gonadotropin, hCG) A hormone see human chorionic gonadotropin.
chorionic somatomammotropin
- (CSH, human lactogen) A hormone synthesized within the placenta by syncytiotrophoblast cells. This protein hormone (190 amino acid) has a structure is similar to pituitary growth hormone.
chronic histiocytic intervillositis
- (massive chronic intervillositis, chronic intervillositis) Rare placental abnormality and pathology defined by inflammatory placental lesions, mainly in the intervillous space (IVS), with a maternal infiltrate of mononuclear cells (monocytes, lymphocytes, histiocytes) and intervillous fibrinoid deposition.
chronic intervillositis
- (massive chronic intervillositis, chronic histiocytic intervillositis) Rare placental abnormality and pathology defined by inflammatory placental lesions, mainly in the intervillous space (IVS), with a maternal infiltrate of mononuclear cells (monocytes, lymphocytes, histiocytes) and intervillous fibrinoid deposition.
- (More? Placenta Abnormalities | Placenta Development)
chronic lung disease
- (CLD) Neonatal chronic lung disease can be caused by prolonged mechanical ventilation (MV) and oxygen-rich gas with premature infants.
- (More? Normal Development - Birth | Respiratory Notes)
chronic myelogenous leukemia
- (CML, chronic myeloid leukemia) Clinical term for a leukocyte (white blood cell) cancer associated with a genetic abnormality of a chromosomal translocation (swapping) that occurs to generate the Philadelphia chromosome. The Philadelphia chromosome t(9;22)(q34;q11) has part of chromosome 9 combined with chromosome 22 that disrupts a gene leading to a Bcr-abl fusion protein.
- (More? Philadelphia chromosome)
chronic villitis
- Placental pathology which can occur following placental infection leading to maternal inflammation of the villous stroma, often with associated intervillositis.
chorionic villus sampling
- (CVS) The taking a biopsy of the placenta, usually at the end of the second month of pregnancy, to test the fetus for genetic abnormalities.
choroid plexus
- A vascular complex in 3rd and 4th ventricle that differentiates to act as an endorgan synthesizing and secreting cerebrospinal fluid (CSF) into the ventricular space of the brain.
- (More? Ventricular System Development)
chromaffin
- The name given to adrenal medulla cells, due to their histological staining with potassium dichromate (brown).
- (More? Adrenal Development | Endocrine System Development | Histology)
chromatin
- (Greek, chroma = color) A diffuse material within the nucleus of a non-dividing eukaryotic cell; consists of DNA and proteins.
chromosomes
- (Greek, chroma = color + soma = body, because it is stained by certain dyes) double stranded DNA coiled around histones. Condenses during mitosis and meiosis.
chryptochid testes
- (cryptorchidism) A male genital abnormality where the testes remain undescended in the abdominopelvic cavity.
- (More? Cryptorchidism | Genital - Male Development)
cilia
- (Latin, cilium = eyelid) Cellular extensions named from the hair-like appearance of a cilium; singular, cilium. In many tissues, cilia are found as epithelial cell apical surface motile specializations. In the uterine tube epithelium, after ovulation used to move the unfertilized egg, then the fertilized zygote, then blastocyst during the first week of development.
ciliated epithelium
- (Latin, cilium = eyelid) An epithelium named on the basis of the cells having surface hair-like appearance of a cilium; singular, cilium. In many tissues, cilia are found as epithelial cell apical surface motile specializations. In the uterine tube epithelium, after ovulation used to move the unfertilized egg, then the fertilized zygote, then blastocyst during the first week of development.
ciliopathies
- Genetic diseases related to the structure and function of cell surface specialization, the primary cilium, required in developmental signaling and sensory functions.
- (More? PMID: 19421068 | PMID: 19477114)
cilium
- (Latin, cilium = eyelid) Cellular extension named from the hair-like appearance of a cilium; plural, cilia. In many tissues, cilia are found as epithelial cell apical surface motile specializations. In the uterine tube epithelium, after ovulation used to move the unfertilized egg, then the fertilized zygote, then blastocyst during the first week of development. Two main types motile cilium and primary cilium.
cingulate gyrus
- Central nervous system structure forming part of the fornicate gyrus along with the parahippocampal gyrus. The central nervous system has an ectoderm origin forming neural plate then neural tube.
circular DNAs
- Genetic material structure found in bacteria, energy-producing organelles (mitochondria, chloroplasts), and many viruses.
cis-regulatory element
- (Latin, cis = on the same side) Gene expression regulation, named because the regulatory element is on the same piece of DNA that is being regulated.
Clara cells
- Respiratory tract epithelial cells on the luminal surface of airways. These cells have a dome shaped cytoplasmic protrusion and no cilia and their function is secretory and xenobiotic. Clara cells can act as progenitor cell in small airways replacing injured terminally differentiated epithelial cells.
- (More? Respiratory System Development)
Clara cell secretory protein
- (CCSP) A protective lung protein secreted from non-ciliated bronchiolar epithelial cells in the conducting airways of mammals. The protein increases in expression level post-natally and is thought to have antioxidant, immunomodulatory, and anticarcinogenic properties.
claudin
- A protein family which forms a component of tight junctions located between cells in the subapical region of the lateral membranes. These proteins in epithelial cells can interact with Eph/ephrin proteins during development to affect cell migration and allow cell sorting to occur.
claudius cells
- (cells of Claudius) Cells of the inner ear cochlea, columnar cells with microvilli overlying the basilar membrane and extend from Hensen's cells to the spiral prominence. Barrier cells that lie external to the organ of corti in endolymph.
clavicle
- (Latin, clavis = key, -cula = small, "collar bone") The bone which locks shoulder to body. In mammals, the clavicle is one of the first bones to ossify by a mix of intramembranous and endochondral ossification from two centres of ossification within a single condensation. The suggested bird equilivalent, the furculae (wishbone), ossifies only by intramembranous within a single center in each condensation.
- (More? Bone Development | Casselman's- Clavis)
cleavage
- A series of rapid cell divisions following fertilization in many early embryos; cleavage divides the embryo without increasing its mass.
cleavage furrow
- A feature of cell division forming a structure or groove in the cytoplasm during cytokinesis (division of cell cytoplasm following mitosis). The furrow forms in the cell membrane in a dividing cell as the contractile ring tightens.
- (More? Cell Division - Mitosis | Cell Division - Meiosis | Week 1)
cleft
- An anatomical gap or space occuring in abnormal development in or between structures. Most commonly associated with cleft lip and cleft palate. Term is also used to describe the external groove that forms between each pharyngeal arch during their formation.
- (More? Palate Development | Head Development | Lecture - Head Development | Medline Plus - Cleft Lip and Palate)
cleft lip
- An abnormality of face development leading to an opening in the upper lip. Clefting of the lip and or palate occurs with 300+ different abnormalities. Depending on many factors, this cleft may extend further into the oral cavity leading to a cleft palate. In most cases clefting of the lip and palate can be repaired by surgery.
cleft palate
- An abnormality of face development leading to an opening in the palate, the roof of the oral cavity between the mouth and the nose. Clefting of the lip and or palate occurs with 300+ different abnormalities. In most cases clefting of the lip and palate can be repaired by surgery. Palate formation in the embryo occurs at two distinct times and developmental processes called primary and secondary palate formation. This leads to different forms (classifications) and degrees of clefting.
- (More? Palate Development | Head Development | Lecture - Head Development | Medline Plus - Cleft Lip and Palate)
cleidocranial dysplasia
- A human genetic bone disease due to a heterozygous mutation in Runx2.
- (More? Bone Development)
clinodactyly
- (Greek, klinein = to bend, slope or incline and dactylos = digit, finger or toe) a curving of the fifth (little) finger toward the fourth (ring) finger. Can be associated with a number of genetic syndromes (trisomy 21 Down syndrome and Klinefelter (XXY) syndrome) or other skeletal abnormalities.
- (More? Limb Abnormalities)
clinical trials
- Clinical experimentation on patients and are designated as phase I, II, or III, based on the type of question and number of people in the study.
- Phase I clinical trials researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
- Phase II clinical trials the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
- Phase III clinical trials the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. (text modified from NIH Clinical Trials site)
clinodactyly
- A musculoskeletal abnormality of development resulting in permanent curving of the fifth finger, usually toward other fingers and can also be seen for other fingers or toes.
- (More? Fetal Alcohol Syndrome)
cloacal membrane
- Forms the external lower membrane limit (caudal end) of the early gastrointestinal tract (GIT). This membrane is formed during gastrulation by ectoderm and endoderm without a middle (intervening) layer of mesoderm. The membrane breaks down to form the initial "anal opening" of the gastrointestinal tract. The upper end of the gastrointestinal tract has a similar embryonic membrane, the [B.htm#buccopharyngeal_membrane buccopharyngeal membrane].
clockface
- A term used to describe the appearance of plasma cell nuclei due to the clumping of the chromatin at the nucleus periphery. More clearly seen in tissue plasma cells that the bone marrow smear, where they are sometimes confused with the basophilic erythroblasts.
clomiphene citrate
- (CC) A fertility drug taken orally to promote the process of follicle/egg maturation in superovulation therapy. (CC) an anti-estrogen (MRL-41) therapy for WHO group II (eu-oestrogenic) infertility associated with polycystic ovary syndrome. Used for more than 40 years it is a simple, cheap treatment, with low side effects and yields a 25% live birth rate. Alternative therapeutics being considered are metformin, aromatase inhibitors and low-dose FSH.
- (More? In Vivo Fertilization | Ovary Development | PMID13901503 | PMID15878925)
clone
- (Greek, klon = twig) A population of genetically identical individuals or cells descended from a single ancestor.
club foot
- The historic common (slang) term for talipes equinovarus a congenital deformity of the foot (occurs approximately 1 in 1,000 births).
- (More? talipes equinovarus)
CNS
- Acronym for Central Nervous System. The structures formed from the neural tube, the brain and spinal cord.
- Ectoderm - neural plate - neural tube - central nervous system
- (More? Neural System Development)
coacervate
- (Latin, coacervatus = heaped up) Discrete tiny droplet into which proteins and polysaccharides can spontaneously concentrate.
coagulation plug
- The uterine epithelium feature located where the blastocyst had entered the uterine wall. In humans, seen approximately day 12 following fertilization.
- (More? Week 2)
coarctation
- (Latin coartare = to press together) Term used to describe a narrowing (stricture, constriction) associated with aortic arch developmental abnormality.
- (More? Cardiovascular Abnormalities)
coarctation of the aorta
- (Latin coartare = to press together) Term used to describe a developmental abnormality of narrowing (stricture, constriction) of the aortic arch.
- (More? Cardiovascular Abnormalities)
coated pit
- A depression in the plasma membrane, lined with clathrin molecules; an intermediate structure in receptor-mediated endocytosis.
cochlea
- The paired inner ear hearing structure that converts mechanical vibrations into an electrical neural signal to be eventually passed to the auditory cortex, how we "hear". The cochlea has many internal structures that embryonically form from the simple epithelium of the otocyst (otic vesicle), which itself formed in early embryonic development from the otic placode. Note there is no "r" on the end of the word.
cochlear implant
- (bionic ear) A generic term term for the medical device that is implanted into the head to aid hearing in a deaf person. First developed in and successfully used 1978 by Graeme Clark, there are now a variety of different implant devices. By the year 2000 more than 13,000 children worldwide have received these implants.
cochlear sac
- Embryonic hearing structure, which will form the coiled cochlear duct and contribute to the saccule.
cochlear aqueduct
- A bony channel containing the fibrous periotic duct. It connects the basal turn of the cochlea perilymphatic space with the subarachnoid space of the posterior cranial cavity.
cochlear ganglia
- (CNVIII, vestibulocochlear ganglia) The auditory component of the vestibulocochlear ganglia containing the neural cell bodies of the cochlear nerve.
cochlin
- A protein forming the major constituent of the inner ear extracellular matrix.
codominant
- Refers to two alleles that each contribute to the phenotype of a heterozygote.
codon
- A group of three nucleotides that specifies a single amino acid residue.
coelom
- Term used to describe a space. There are extraembryonic and intraembryonic coeloms that form during vertebrate development. The initial single intraembryonic coelom located in the lateral plate mesoderm will form the 3 major body cavities: pleural, pericardial and peritoneal.
- Intraembryonic Coeloms: pericardial cavity - pleural cavity - peritoneal cavity
- (More? Coelomic Cavity Development)
coelocentesis
- A sampling of extracoelomic fluid usually for an early prenatal diagnostic technique.
coenzyme
- An organic molecule (but not a protein) that is a necessary participant in an enzyme reaction.
collagen
- A helical fibrous abundant protein of the extracellular matrix. The regular structure found principally in the structural protein collagen; the collagen helix consists of three polypeptide chains.
columella
- The chicken middle ear ossicle (bone) forms from the proximal ectomesenchyme of the second pharyngeal arch. The footplate of the bone inserts into the inner ear oval window and the shaft then spans the middle ear cavity and the artilaginous extracolumella inserts into the tympanic membrane.
- (More? Chicken Development | Middle Ear Development | PMC2834582 | PMID20158901)
colostrum
- The maternal mammary gland secretion that occurs at birth which precedes the secretion of milk.
- (More? Mammary Glands)
colpocephaly
- A neural developmental abnormality occurring as an enlargement of the brain occipital horns resulting from white matter in the posterior cerebrum failure to develop. The brain occipital horns refer to the posterior or rear portion of the lateral ventricles (cavities) of the brain.
column chromatography
- A type of chromatography in which the stationary phase is an insoluble material packed into a glass or metal column.
commensalism
- An association between individuals of two species in which one organism benefits without harming the other one, as in commisural bacteria in the gastrointestinal tract.
commisural bacteria
- Bacteria that postnatally populate the gastrointestinal tract and assist in processing waste products of digestion.
communicating junctions
- Membrane-associated structures that allow small molecules to pass freely between two adjacent cells.
comparative genomic hybridization
- (CGH, comparative genomic hybridisation, chromosomal microarray analysis) A prenatal screening technique that allows detection of chromosomal abnormalities. This new technique is currently also being developed and tested for in vitro fertilization screening.
competitive inhibitor
- A molecule whose inhibitory effects on an enzyme can be overcome by increased substrate concentration.
complement
- A set of blood proteins that attack microbial invaders.
complementarity determining region
- (CDR) The segment of an immunoglobulin molecule most involved in binding antigen; so called because its shape is complementary to that of the antigen.
complex disease
- Types of diseases which aggregate in families but do not segregate in a Mendelian fashion.
computed tomography
- (CT, CT scan, CAT) A new imaging technique begun in 1970's using x-ray and a computer to produce images either as individual slices or reconstructed to give three dimensional (3D) views of specific anatomical regions or structures. See also multidetector computed tomography (MDCT) that uses several detectors.
conceptus
- The entire product of conception, that is all the structures derived from the zygote and includes not only the embryo, but also the placental and membrane components.
- (More? Week 1)
chondroitin sulphate
- (chondroitin sulfate) An extracellular matrix glycosaminoglycan of alternating sugars (N-acetylgalactosamine and glucuronic acid). A proteoglycan is formed when it is attached to a protein. In zebrafish, expression is required for normal cardiac atrioventricular canal formation.
- (More? Lecture - Extracellular Matrix | PMID19890913)
conductive loss
- The term used to describe one of the two major classes of hearing loss involving external and middle ear abnormalities (other form is sensorineural loss).
congenital
- Already present at birth, often used to describe defects present at birth, congenital anomalies or congenital defects. The euphemism or informal term "birth defects" is not an appropriate description to be used.
- (More? Human Abnormal Development)
congenital adrenal hyperplasia
- (CAH, adrenal virilism) Abnormality of the fetal adrenal cortex, alters cortisol and androgens with different effects dependent upon sex: in females masculization of the external genitalia; in males, disorder often unnoticed until postnatally. In both sexes, accelerated skeletal growth and sexual maturation is seen in late childhood. Caused by a deficiency or absence of the enzyme 21-hydroxylase in the adrenal cortex. Grouped with the Disorders of Sex Development (DSD).
congenital anomalies
- Developmental abnormalities detected before or present at birth. There are no internationally agreed definitions for congenital anomalies and there are a range of classifications including the International Classification of Diseases (ICD), developed by the World Health Organization (WHO) to enable comparability for mortality statistics.
- (More? Human Abnormal Development)
congenital dislocated hip
- (congenital hip dislocation, congenital hip dysplasia, developmental dysplasia of the hip, DHH) See the preferred term developmental dysplasia of the hip (DHH), which includes presentation following a normal examination of the hips in the newborn period. Term refers to a spectrum of musculoskeletal disorders of hip instability due either to the femoral head being able to move outside the acetabulum (luxation or dislocation), or abnormally within the acetabulum (subluxation or partial dislocation).
connecting stalk
- Term describing the linking (connecting) region of the embryonic disc to the chorionic membrane wall by a short region (stalk) of extraembryonic mesoderm. The connecting stalk relative to the embryonic disc lies lies at the caudal end below both the primitive streak and the cloacal membrane. This extraembryonic mesoderm will later develop blood vessels and contribute to the placental cord (umbilical cord) structure. In humans, this early structure forms during week 3 of development.
- (More? Week 3 | Placenta Development)
connexin
- (gap junction protein) Family of transmembrane proteins that assemble to form channels between two adjacent cells for rapid cell communication (signaling). A gap junction is formed from six connexin molecules on one cell forming a hemi-channel (connexon) which attaches to the same structure on an adjacent cell. (Cx26, Cx31, Cx43, Cx40)
- (More? - Cell Junctions)
connexin 43
- (Cx43) A gap junction protein expressed in the human placenta required for the fusion of cytotrophoblast cells to form a syncytiotrophoblast cell.
- (More? - Cell Junctions | PMID18783825)
contact inhibition
- A developmental form of cell to cell signaling that arrests cell division in a population of cells when they reach a high or specific density and contact each other. It is seen in epithelial and mesenchymal development and is also a key anticancer mechanism, limiting the proliferative activity of cells. Cancer cells grown in vitro do not respond to contact inhibition.
contraindication
- Clinical term for a reason why a drug or vaccine must not be given to a patient.
Coombs test
- A diagnostic test named after Robin Coombs (1921-), a British immunologist who developed a technique of using antibodies that are targeted against other antibodies used in the test for erythroblastosis fetalis (Haemolytic disease of the newborn).
- (More? Placenta Development- Abnormalities | Blood Groups and Red Cell Antigens Hemolytic disease of the newborn)
copy number variation
- (CNV) Genetics term referring to a variability in genome DNA when comparing differences of two or more genomes. The size difference ranges from one kilobase to several megabases in size and occupy about 5–12% of the human genome.
cord blood
- (human umbilical cord blood, HUCB) A term used to describe blood collected from the placenta usually after birth. Has been identified as a source of stem cells with potential therapeutic uses and is stored in Cord Blood Banks throughout the world.
- (More? Placenta Development | [[Stem Cells - Placental Cord Blood])
cord knot
- (umbilical cord knot) Term describing umbilical or placental cord knotting. A knot is a general term describing a compact intersection of interlaced material, such as cord, ribbon, or rope. This occurs in about 1% prevents the passage of placental blood, pseudoknots also occur usually with no effect.
cord presentation
- A term used to describe at birth the presence of the umbilical cord between the fetal presenting part and the cervix, with or without membrane rupture.
- (More? Birth | Placenta - Cord | Placenta - Abnormalities)
cord prolapse
- A term used to describe at birth the descent of the umbilical cord through the cervix alongside (occult) or past (overt) the presenting part in the presence of ruptured membranes (incidence of 0.1% to 0.6%).
- (More? Birth | Placenta - Cord | Placenta - Abnormalities)
corneal stroma
- An eye structural component of the cornea. In chicken, formed by a two-stage process of collagen fibril deposition, a primary stroma secreted by epithelial cells and a secondary stroma by the invading neural crest cells (corneal keratocytes).
- (More? Sensory - Vision Development)
cornual pregnancy
- (interstitial pregnancy) Actually means a pregnancy in the rudimentary horn of a bicornuate uterus, the term is used to describe an interstitial pregnancy.
- (More? Ectopic Implantation)
corona radiata
- The granulosa cells that directly surround the oocyte, within the antral follicle of the ovary. These cells are released along with the oocyte at ovulation and provide physical protection and the initial structural barrier that spermatazoa must penetrate during fertilization. Other granulosa cells within the follicle include: membrana granulosa and cumulus oophorus.
coronary artery
- Embryonic origin (mouse) for all coronary vessels is from angiogenic sprouts of venous endothelial cells from the sinus venosus.
- (More? Coronary Circulation Development)
corpora amylacea
- (Latin, corpus = body) Histology term for a characteristic feature of the prostate of rounded eosinophilic bodies located in the secretory alveoli. The average diameter is about 0.25 mm (up to 2 mm) and appear from the seventh month of fetal development. Their number increases with age (in particular past 50) and may undergo calcification and may also appear in semen.
corpus albicans
- (Latin, corpus = body, albicans = whitish) The histological structure formed by luteolysis of the corpus luteum in the ovary. If implantation does not occur and the hormone hCG is not released the corpus luteum degenerates and the structure is white, not yellow, because of the absence of steroid hormone synthesis/accumulation.
- (More? Menstrual Cycle | Ovary Development | Week 2)
corpus luteum
- (Latin, corpus = body, luteum = yellow) The remains of ovarian follicle formed after ovulation that acts as an endocrine organ (produce progesterone and oestrogens) supporting pregnancy and preventing menstruation (loss of the endometrial lining). Formed during the luteal phase (secretory phase) of the menstrual cycle by proliferation of both follicular granulosa cells (granulosa lutein cells) and thecal cells (theca lutein cells), which produce progesterone and oestrogens. If fertilization and pregnancy does not occur, the corpus luteum degenerates to form the corpus albicans. Regnier de Graaf (1641 – 1673) first observed it in the ovary of a cow as a yellow structure, the yellow colour is caused by accumulation of steroidal hormones.
- (More? Menstrual Cycle | Ovary Development Week 2)
cortex
- (Latin, corticalis = at the outside) outer layer, used in association with medulla (innner layer or core) a general description that can be applied to describing an organ with a layered structure. Also used to describe the outer cellular (grey matter) layer of the central nervous system.
cortical
- (Latin, corticalis = at the outside) like the bark of a tree, usually combined with medulla meaning the core. Also used to describe the outer cellular layer of the central nervous system.
cortical granule
- The oocyte cytoplasm prior to fertilization contains just beneath the plasma membrane (cortical) many specialized secretory vesicles (granules). After fertilization, these vesicles fuse with the plasma membrane, releasing their contents, which block polyspermy.
- (More? Fertilization)
cortical plate
- The outer neural tube region where post-mitotic neuroblasts migrate too along radial glia to eventually form the adult cortical layers.
- (More? Neural System Development)
corticospinal tract
- (pyramidal tract) Neural term describing the central nervous system connection between the cortex (sensorimotor areas) and the spinal cord involved with mainly the motor (skeletal muscle) control. Within the brainstem about 80% of the fibres crossover to opposite sides (pyramidal decussation) and continue to descend in the spinal cord lateral white column of the opposite side. The remaining 20% of the fibres do not cross (ipsilateral) in the ventro-medial white column, to innervate bilaterally the more medially located motor neurons of the axial and proximal muscles. At birth this pathway has not completed myelination, which continues postnatally, and leads to the presence of the primitive reflex called the Babinski reflex.
- (More? Neural System Development | Neural Exam - Newborn reflexes - plantar reflex | Neonatal Development | Medline Plus - Babinski's reflex)
corticosteroid
- An endocrine steroidal hormone produced by the adrenal cortex. Clinically, corticosteroids are also used for lung maturation of the premature neonate.
- (More? Endocrine - Adrenal Development | Endocrine System Development | Respiratory System Development)
corticotropin-releasing hormone
- (CRH) A hypothalamic neuropeptide hormone, which is also produced by embryonic trophoblast and maternal decidua cells, with receptors in several reproductive organs. Thought to have a role in endometrial decidualization, blastocyst implantation and early maternal tolerance.
cotyledon
- (Greek, kotyle = a deep cup) In the embryos of seed plants, the "seed leaves," in which nutrients are stored for use after germination. In placental animals, the term is also to describe the leaf-like structure of the placenta surface.
- (More? Placenta Development)
Cowper's Gland
- (Bulbourethral Gland) A male genital tract gland which secretes a small amount of a thick clear mucous fluid prior to ejaculation, the alkaline content apparently buffers acidity of the urethra. The equivalent female gland are Bartholin's glands.
- (More? Genital - Male Development)
cranial flexure
- (midbrain or cephalic flexure) In development of the central nervous system brain region, the most cranial early neural tube flexure (cranial flexure, pontine flexure and cervical flexure)), lying between the mesencephalon and prosencephalon, of the three flexures (bends) that initially form as the nueral tube grows and elongates.
- (More? Neural System Development)
cranial neuropore
- (rostral, cephalic or anterior) The opening of the early neural tube in the head region. Initially when the neural plate folds and fuses it leaves two openings at either end cranial and caudal that close later. In humans, the cranial neuropore closes at Carnegie stage 11 (about 24 days) within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in several areas simultaneously.
- (More? Neural System Development)
craniofrontonasal syndrome
- (CFNS) A human X-linked developmental disorder caused by a mutation in ephrin-B1 affecting mainly females. Characterised by abnormal development of cranial and nasal bones, craniosynostosis (premature coronal suture fusion), and other extracranial anomalies (limb polydactyly and syndactyly).
craniopharyngioma
- A common destructive tumorogenic lesions of the hypothalamus and pituitary gland. Can occur when remnant cells from Rathke's pouch remain forming a tumour.
- (More? Endocrine - Hypothalamus | Endocrine - Pituitary )
craniorachischisis
- Abnormal development of the neural tube defect class with an abnormal opening of the skull and vertebral column.
craniorachischisis totalis
- Abnormal development of the neural tube defect class, with failure of fusion of the entire neural tube.
craniosynostosis
- The term describing the premature closure of the skull sutures, or fusion of skull bones. May cause skull and brain abnormalities. There are at least 8 different disorders with six related to the fibroblast growth factor receptor (FGFR); Pfeiffer syndrome, Apert syndrome, Crouzon syndrome, Beare-Stevenson syndrome, FGFR2-related isolated coronal synostosis, Jackson-Weiss syndrome, Crouzon syndrome with acanthosis nigricans (AN), and Muenke syndrome.
- (More? Head Notes | Head Abnormalities | Bone Notes | Bookshelf - GeneReviews)
CREB
- Acronym for Cyclic-AMP response element binding protein. CREB is a member of the basic region leucine zipper (bZIP) family of transcription factors and requires phosphorylation to become a biologically active transcriptional activator. CREB binds to CRE (Cyclic-AMP response element) which is the final target of many extracellular and intracellular signals (e.g. cAMP, calcium, neurotrophins).
- (More? Molecular Development)
CrebA
- Acronym for Cyclic-AMP response element binding protein A involved in gene activation. Drosophila have two genes (A and B-17A) encoding the cAMP response element binding (CREB) protein family members. These proteins have mammalian equilivants with RNA polymerase II transcription factor activity, DNA binding, transcription factor activity, protein homodimerization activity.
- (More? Molecular Development)
cretinism
- The term describing a neurological abnormality due to insufficient thyroid hormone during neural development. The main cause of this disorder is an insufficiency or lack of iodine in the diet.
cribiform plate
- Anatomical structure of the head, describing the perforated portion of ethmoid bone of skull allows passage of olfactory axons from nasal epithelium to olfactory bulb.
- (More? Senses Notes)
CRISP
- Acronym for cysteine-rich secretory protein, a group of proteins (CRISP1, CRISP2) recently suggested to have a role in sperm-egg fusion through binding to egg-complementary sites.
- (More? Fertilization)
cristae ampullaris
- Inner ear structure associated with equilibrium located in the ampulla of the membranous semicircular canals a region with both supporting and hair cells. The hair cell cilia are embedded in the gelatinous cupula.
- (More? Lecture - Hearing)
critical period
- (critical period of development) The term used to describe a developmental time when exposure to a teratogen can lead to a developmental abnormality, which can be further divided into an early major and later minor developmental abnormality. The defined critical period will differ in timing and length for different systems.
CRL
- Acronym for Crown-Rump Length. Used in embryology to accurately stage the early embryo. Used in clinical ultrasound as a measurement between the periods of 7 to 13 weeks as an accurate estimation of the gestational age.
- (More? Embryo Stages | Ultrasound Movies)
Crown-rump length
- (CRL) A measurement used in embryology to more accurately stage the early embryo. Measured from the curvature at the top (crown) to the curvature at the bottom (rump) of the "C-shaped" early embryo. Used in clinical ultrasound as a measurement between the periods of 7 to 13 weeks as an accurate estimation of the gestational age.
- (More? Embryo Stages | Ultrasound Movies)
cryptopatches
- (CPs) An immune system structure, small clusters of lymphoid cells with an immature lymphocyte phenotype and dendritic cells found associated with the gastrointestinal tract.
cryopreservation
- A technique for freezing tissue or cells to preserve for use at a later date. In this report, cryopreserved embryos are referred to as frozen embryos.
cryptophthalmos
- The term describing an anomaly of eye development, with a continuity of the skin from the forehead to the cheek over a malformed eye. Classified into three types: complete, incomplete and abortive.
- (More? Eye Abnormalities)
cryptorchidism
- An abnormality of either unilateral or bilateral testicular descent, occurring in < 30% premature and 3-4% term males. Descent may complete postnatally in the first year, failure to descend can result in sterility.
- (More? Urogenital Notes | Genital Abnormalities)
CSH
- Acronym for chorionic somatomammotropin hormone, a placental hormone.
cuboidal epithelium
- An epithelial layer formed by cells with a cuboidal shape (morphology), compared to the other two main hsitological cell shapes (squamous, columnar). Cuboidal, equal height and width, for example, endodermal or peripheral ectodermal layers of the trilaminar embryo.
cumulus oophorus
- (Latin cumulus = a little mound G. oon = egg + phorus = bearing) The granulosa cells that form a column of cells that attaches the oocyte to the antral follicle wall within follicles of the ovary. This column of cells is broken or separates during ovulation to release the oocyte from its follicle attachment. Other granulosa cells within the follicle include: membrana granulosa and corona radiata.
cupular deposits
- In the vestibular system, the basophilic material on the cupulae of the semicircular ducts, an postnatal ageing phenomenon seen in some vestibular labyrinth.
Cushing's syndrome
- (hypercortisolism) A relatively rare metabolic hormonal disorder caused by prolonged exposure of the body’s tissues to high levels of the adrenal hormone cortisol, most commonly affects adults aged between 20 to 50 and also the obese with type 2 diabetes.
- (More? Endocrine - Adrenal Development | NIH - NIDDK)
cyanosis
- Clinical term referring to a blue coloration of the skin and mucous membranes due to the presence of deoxygenated hemoglobin. Can be due to several different causes including cyanotic heart disease.
cyanotic heart disease
- Clinical term referring to a congenital heart abnormality (defect) resulting in lack of oxygen that causes cyanosis, a blue coloration of the skin and mucous membranes due to the presence of deoxygenated hemoglobin.
cyclophosphamide
- Drug used in the treatment of various cancers and some autoimmune disorders. It is converted in the liver, by oxidase enzymes, to its active forms and has identified developmental teratogenic activity.
cyst
- The pathological term describing a fibrous capsule containing fluid.
cyto-
- (Greek, kytos = hollow vessel or container) Prefix referring to a "cell" or "cellular", as is the the suffix "-cyte".
cytochrome
- (Greek, kytos = hollow vessel + chroma = color) One of a set of heme-containing electron carrier proteins in mitochondria that change color as they accept or donate electrons.
cytokinesis
- (Greek, kytos = hollow vessel + kinesis = movement) The division of the cell cytoplasm and its contents that occurs following mitosis in cell division leading to two separate daughter cells. This process overlaps mitosis telophase and generates two separate plasma membranes.
- (More? Week 1 Notes)
cytomegalovirus
- A virus that infection of early embryos is fatal, infection of later fetuses can lead to blindness, deafness, cerebral palsy, and mental retardation.
- (More? Abnormal Development- Virus | PMID: 19067401)
cytotrophoblast
- The "cellular" trophoblast layer surrounding (forming a "shell") the early implanting conceptus. Beginning at uterine adplantation, proliferation and fusion of these cells is thought to form a second outer trophoblast layer, the syncytiotrophoblast. The cytotrophoblast layer contributes to formation of the placental villi, the functional component of the fetal placenta.
cytosine
- (cytosine triphosphate) One of the four types of nucleotides (ATCG) that make up DNA. Base pairs with guanine by 3 hydrogen bonds.
Glossary Comments
Use this page to access brief definitions of specific embryology terms. Additional information can be accessed from links listed at the end of each definition. Glossary from the UNSW Embryology program compiled and written by Dr Mark Hill. Reference material used in preparing this glossary list includes: texts listed on page 1 "Reading" of each notes section, Department of Anatomy Publications, WWW resources from NCBI, NIH, OMIM, NHMRC (Australia), AMA (USA), Office of Rare Diseases (USA), PubMed Medline Dictionaries, MSDS, Merck Manual home edn. and WHO ART terminology (2009).
These notes are for Educational Purposes Only Please email Dr Mark Hill if you wish to make a comment about this current project.
Glossary Links
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Cite this page: Hill, M.A. (2024, May 25) Embryology C. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/C
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G