Developmental Signals - Anti-Mullerian Hormone
Embryology - 20 Jun 2024 Expand to Translate |
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Introduction
Anti-Mullerian Hormone (AMH; Mullerian Inhibiting Substance, MIS; Mullerian Inhibiting Factor, MIF) is a secreted glycoprotein factor (transforming growth factor-beta, TGF-beta superfamily) that regulates gonadal and genital tract development. In the male embryo, the Sertoli cell secrete AMH and inhibit paramesonephric (Mullerian) duct development. In postnatal males, AMH increases during the first month, reaching peak level at 6 months of age, and then slowly declines during childhood falling to low levels in puberty.
In reproductive age women, AMH is produced in the ovary by the granulosa cell surrounding preantral and small antral follicles and serum levels may reflect the remaining follicle cohort and decrease with age.
- Links: AMH | Male | Ovary Development | Oocyte Development | Testis
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Anti-Mullerian Hormone <pubmed limit=5>Anti-Mullerian Hormone</pubmed> |
Movies
<html5media height="500" width="200">File:Testis 001.mp4</html5media> |
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Gene
- cytogenetic location - 19p13.3
- human gene has 5 exons
- Links: HGNC | OMIM - AMH
Protein
- Secreted protein
- 560 amino acid polypeptide
- C-terminal domain homology with human transforming growth factor-beta and the beta chain of porcine inhibin
- Links: UniProt
Functions
AMH can inhibit the autophosphorylation of the Epidermal Growth Factor Receptor (EGFR) in vitro even though it does not compete with EGF for receptor binding sites.
Genital Development
References
Reviewss
Articles
Kissell KA, Danaher MR, Schisterman EF, Wactawski-Wende J, Ahrens KA, Schliep K, Perkins NJ, Sjaarda L, Weck J & Mumford SL. (2014). Biological variability in serum anti-Müllerian hormone throughout the menstrual cycle in ovulatory and sporadic anovulatory cycles in eumenorrheic women. Hum. Reprod. , 29, 1764-72. PMID: 24925522 DOI.
Search Pubmed
Search Pubmed: Anti-Mullerian Hormone | AMH
Search Bookshelf: Anti-Mullerian Hormone
External Links
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Cite this page: Hill, M.A. (2024, June 20) Embryology Developmental Signals - Anti-Mullerian Hormone. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Anti-Mullerian_Hormone
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G