Developmental Signals - Hippo: Difference between revisions
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Revision as of 11:01, 11 June 2015
Embryology - 15 Jun 2024 Expand to Translate |
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Introduction
The Hippo (Hpo) pathway, first identified in Drosophila, controls organ size by regulating cell proliferation (inhibition) and apoptosis (induction). In contrast, the TOR signalling pathway regulates organ size by stimulating cell growth, thus increasing cell size.
Hippo is a protein kinase cascade pathway, getting its name from the “hippopotamus”-like phenotype.
Fly Phenotype (dorsal view head thorax SEM) | |
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Hippo-type (hpo) | Wild-type (WT) |
Image source[1] |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Embryo Hippo | Images <pubmed limit=5>Embryo Hippo</pubmed> |
Early Development
Blastocyst
Mouse blastocyst (32 cell stage) | |
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phosphorylation of angiomotin at adherens junctions | cell polarization sequesters Amot from basolateral adherens junctions |
active Hippo signaling | inactive Hippo signaling |
inner cells | outer cells |
inner cell mass (ICM) fate | trophectoderm (TE) fate |
- (Table data see review[2] Notch signaling also has a role in blastocyst fate development)
- Links: Blastocyst
Organ Expression
Endoderm
Fetal Gonad
Neural
References
- ↑ 1.0 1.1 <pubmed>24336504</pubmed>| Nat Rev Drug Discov.
- ↑ 2.0 2.1 <pubmed>25986053</pubmed>
Reviews
<pubmed>26032720</pubmed> <pubmed>22575479</pubmed> <pubmed>21808241</pubmed> <pubmed>19517570</pubmed>
Articles
<pubmed>25628125</pubmed> <pubmed>25918243</pubmed> <pubmed></pubmed> <pubmed></pubmed>
Search Pubmed
Search Bookshelf Hippo
Search Pubmed Now: Hippo
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 15) Embryology Developmental Signals - Hippo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Hippo
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G